Symmetry of Post-Translational Modifications in a Human Enzyme

Autor: Teresa Maria Carusone, Giuseppe Manco

Publikováno v: Symmetry, Vol 14, Iss 2, p 212 (2022)

Paraoxonase 2 (PON2) is a member of a small family of human lactonases. Recently, post-translational modifications (PTMs) of PON2 were highlighted, one of which involved the modulation of the enzyme activity. Furthermore, two important single nucleot

Externí odkaz: https://doaj.org/article/f23fd7e194364f3f8b7a6e5a2c239931

Innovative Biocatalysts as Tools to Detect and Inactivate Nerve Agents

Autor: Valentina De Luca, Piero Porcaro, Elena Porzio, Franz Worek, Ilaria Palchetti, Antonio Pisanti, Giuseppe Manco, Teresa Maria Carusone, Immacolata Del Giudice, Mario De Rosa, Odile F. Restaino, Maria Giovanna Borzacchiello, Chiara Schiraldi, Serena Laschi, Francesca Bettazzi, Luigi Mandrich, Ferdinando Febbraio

Publikováno v: 13th International Meeting on Cholinesterases-7th International Conference on Paraoxonases", 9-14/9/2018.
info:cnr-pdr/source/autori:Elena Porzio1*, Francesca Bettazzi2*, Luigi Mandrich1, Immacolata Del Giudice1, Odile F. Restaino3, Serena Laschi4, Ferdinando Febbraio1, Valentina De Luca1, Maria G. Borzacchiello3, Teresa M. Carusone1, Franz Worek5, Antonio Pisanti6, Piero Porcaro6, Chiara Schiraldi3, Mario De Rosa3, Ilaria Palchetti2, Giuseppe Manco1#/congresso_nome:13th International Meeting on Cholinesterases-7th International Conference on Paraoxonases"/congresso_luogo:/congresso_data:9-14%2F9%2F2018./anno:2018/pagina_da:/pagina_a:/intervallo_pagine
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific reports (Nature Publishing Group) 8 (2018). doi:10.1038/s41598-018-31751-5
info:cnr-pdr/source/autori:Porzio, Elena; Bettazzi, Francesca; Mandrich, Luigi; Del Giudice, Immacolata; Restaino, Odile F.; Laschi, Serena; Febbraio, Ferdinando; De Luca, Valentina; Borzacchiello, Maria G.; Carusone, Teresa M.; Worek, Franz; Pisanti, Antonio; Porcaro, Piero; Schiraldi, Chiara; De Rosa, Mario; Palchetti, Ilaria; Manco, Giuseppe/titolo:Innovative Biocatalysts as Tools to Detect and Inactivate Nerve Agents/doi:10.1038%2Fs41598-018-31751-5/rivista:Scientific reports (Nature Publishing Group)/anno:2018/pagina_da:/pagina_a:/intervallo_pagine:/volume:8

Pesticides and warfare nerve agents are frequently organophosphates (OPs) or related compounds. Their acute toxicity highlighted more than ever the need to explore applicable strategies for the sensing, decontamination and/or detoxification of these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf3fcd48f5d1f1f0d577df6710f040cc
http://www.cnr.it/prodotto/i/393478

An efficient thermostable organophosphate hydrolase and its application in pesticide decontamination

Autor: Immacolata, Del Giudice, Rossella, Coppolecchia, Luigia, Merone, Elena, Porzio, Teresa Maria, Carusone, Luigi, Mandrich, Franz, Worek, Giuseppe, Manco

Publikováno v: Biotechnology and bioengineering. 113(4)

In vitro evolution of enzymes represents a powerful device to evolve new or to improve weak enzymatic functions. In the present work a semi-rational engineering approach has been used to design an efficient and thermostable organophosphate hydrolase,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::acf272a0e01878ec4bdfea5d81e374cd
https://pubmed.ncbi.nlm.nih.gov/26416557