Higher β cell death in pregnant women, measured by DNA methylation patterns of cell-free DNA, compared to new-onset type 1 and type 2 diabetes subjects: a cross-sectional study

Autor: Teresa María Linares-Pineda, Carolina Gutiérrez-Repiso, Nerea Peña-Montero, María Molina-Vega, Fuensanta Lima Rubio, María Suárez Arana, Francisco J. Tinahones, María José Picón-César, Sonsoles Morcillo

Publikováno v: Diabetology & Metabolic Syndrome, Vol 15, Iss 1, Pp 1-8 (2023)

Abstract Diabetes is a metabolic disorder of glucose homeostasis in which β cell destruction occurs silently and is detected mainly when symptoms appear. In the last few years, it has emerged a great interest in developing markers capable of detecti

Externí odkaz: https://doaj.org/article/238d7558ded64ae2a510102d16e16084

Changes in Oxidative Stress and Intestinal Permeability during Pregnancy in Women with Gestational Diabetes Mellitus Treated with Metformin or Insulin and Healthy Controls: A Randomized Controlled Trial

Autor: Andrea Fernández-Valero, Nerea Peña-Montero, Fuensanta Lima-Rubio, Carolina Gutiérrez-Repiso, Teresa María Linares-Pineda, María José Picón-César, Raquel Sancho-Marín, Francisco J. Tinahones, Sonsoles Morcillo, María Molina-Vega

Publikováno v: Antioxidants, Vol 12, Iss 11, p 1981 (2023)

Both oxidative stress and intestinal permeability are increased in hyperglycemic situations and have been shown to be reduced by metformin in type 2 diabetes mellitus (T2DM) patients. The aim of this study was to elucidate the effect of metformin on

Externí odkaz: https://doaj.org/article/ae66abf7e367412b9fd491a154895f6b

Epigenetic Biomarkers of Transition from Metabolically Healthy Obesity to Metabolically Unhealthy Obesity Phenotype: A Prospective Study

Autor: Sergio Valdés, Francisco J. Tinahones, Andres Gonzalez-Jimenez, Francisca Aguilar-Lineros, Teresa María Linares-Pineda, Sonsoles Morcillo, Gemma Rojo-Martínez, Federico Soriguer, Carolina Gutiérrez-Repiso

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10417, p 10417 (2021)

Background: Identifying those parameters that could potentially predict the deterioration of metabolically healthy phenotype is a matter of debate. In this field, epigenetics, in particular DNA methylation deserves special attention. Results: The aim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c65c084b32f30b0d6b4a6b93fe56cb3

Gene polymorphisms as predictors of response to biological therapies in psoriasis patients

Autor: Miguel Ángel Calleja-Hernández, Marisa Cañadas-Garre, Teresa María Linares-Pineda, Antonio Sánchez-Pozo

Publikováno v: Pharmacological Research. 113:71-80

Psoriasis is a chronic inflammatory autoimmune skin disease, characterized by the formation of erythematous scaly plaques on the skin and joints. The therapies for psoriasis are mainly symptomatic and sometimes with poor response. Response among pati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d80bd2f7507414b3d477d7169718655
https://doi.org/10.1016/j.phrs.2016.07.020