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Publikováno v:
Infection Control and Hospital Epidemiology. 16:354-358
The antistaphylococcal activity of topical mupirocin has made it an attractive agent for the treatment of asymptomatic colonization with Staphylococcus aureus. Increasing use has been associated with the emergence of mupirocin resistance in staphyloc
Autor:
Jan Evans Patterson, Teresa M. Morton, Mary A. Ramsey, David R. Reagan, Suzanne F. Bradley, Carol A. Kauffman
Publikováno v:
Antimicrobial agents and chemotherapy. 42(5)
With the increasing use of mupirocin, resistance among staphylococci has emerged (1). High-level resistance (MICs, >500 μg/ml) is usually mediated by a plasmid-associated mupA gene. Low-level resistance (MICs
Publikováno v:
Antimicrobial agents and chemotherapy. 40(12)
Low- and high-level mupirocin resistance have been reported in Staphylococcus aureus. The expression of plasmid-encoded mupA is responsible for high-level mupirocin resistance. Low-level mupirocin-resistant strains do not contain plasmid-encoded mupA