Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Teresa M. Mascenik"'
Autor:
Rhianna E. Lee, Catherine A. Lewis, Lihua He, Emily C. Bulik-Sullivan, Samuel C. Gallant, Teresa M. Mascenik, Hong Dang, Deborah M. Cholon, Martina Gentzsch, Lisa C. Morton, John T. Minges, Jonathan W. Theile, Neil A. Castle, Michael R. Knowles, Adam J. Kimple, Scott H. Randell
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 18 (2022)
The vast majority of people with cystic fibrosis (CF) are now eligible for CF transmembrane regulator (CFTR) modulator therapy. The remaining individuals with CF harbor premature termination codons (PTCs) or rare CFTR variants with limited treatment
Externí odkaz:
https://doaj.org/article/0342006f024949bb976f55db34ef1e17
Autor:
Rhianna E. Lee, Teresa M. Mascenik, Sidra C. Major, Catherine A. Lewis, James E. Bear, Raymond J. Pickles, Scott H. Randell
Cell therapy is a potential treatment for cystic fibrosis (CF). However, cell engraftment into the airway epithelium is challenging. Here, we model cell engraftmentin vitrousing the air-liquid interface (ALI) culture system by injuring well-different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6b77ee35e3508cae13e80e850e48c79
https://doi.org/10.1101/2022.11.14.516213
https://doi.org/10.1101/2022.11.14.516213
Autor:
Wanda K. O'Neal, Rhianna E. Lee, Teresa M. Mascenik, Takanori Asakura, Hong Dang, Lisa C. Morton, Barbara R. Grubb, Hirotoshi Matsui, Martina Gentzsch, Richard C. Boucher, Carlton W Anderson, Kenichi Okuda, Gang Chen, Purushothama Rao Tata, Yvonne K. O’Neal, Satoko Nakano, Takahide Nagase, Yoshihiko Kobayashi, Michael Chua, Selene Margarita Barbosa Cardenas, Nancy L. Quinney, John C. Olsen, Andrew J. Ghio, Gianni Carraro, Caroline E Minnick, Lawrence E. Ostrowski, Rodney C. Gilmore, Takafumi Kato, Scott H. Randell, Barry R. Stripp, Weining Yin
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 203:1275-1289
Rationale: Identification of the specific cell types expressing CFTR (cystic fibrosis [CF] transmembrane conductance regulator) is required for precision medicine therapies for CF. However, a full ...
Autor:
Rhianna E. Lee, Hong Dang, Zachary H Boggs, Teresa M. Mascenik, Robert Tarran, Catherine A. Lewis, Sean M. Miller, Scott H. Randell
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology
Cystic fibrosis (CF) is caused by loss-of-function mutations in the CFTR (CF transmembrane regulator) gene. Pharmacologic therapies directed at CFTR have been developed but are not effective for mutations that result in little or no mRNA or protein e
Autor:
Lihua He, Hong Dang, Scott H. Randell, Rhianna E. Lee, Minges Jt, Lisa C. Morton, Castle Na, Adam J. Kimple, Theile Jw, Michael R. Knowles, Catherine A. Lewis, Gallant Sc, Teresa M. Mascenik
With the approval of elexacaftor/tezacaftor/ivacaftor (trade name Trikafta), the vast majority of people with cystic fibrosis (CF) are eligible for CF transmembrane conductance regulator (CFTR) modulator therapy. Remaining individuals have premature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2de0779d2aa54a95f1251c245e574cd9
https://doi.org/10.1101/2021.09.28.462149
https://doi.org/10.1101/2021.09.28.462149
Autor:
Kenichi Okuda, Alena J. Markmann, Tadaki Suzuki, Sarah R. Leist, Shiho Chiba, Kenneth H. Dinnon, Caitlin E. Edwards, Rhianna E. Lee, Yoshihiro Kawaoka, David M. Margolis, Luther A. Bartelt, Kenta Takahashi, Noriko Nakajima, Makoto Kuroda, Aravinda M. de Silva, Yixuan J. Hou, Rachel L. Graham, Ralph S. Baric, Camille Ehre, Longping V. Tse, Teresa M. Mascenik, Lisa E. Gralinski, Scott H. Randell, Peter Halfmann, Richard C. Boucher, Alexandra Schäfer
Publikováno v:
Science
Changing with the timesPandemic spread of a virus in naïe populations can select for mutations that alter pathogenesis, virulence, and/or transmissibility. The ancestral form of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerg
Autor:
Scott H. Randell, Adam R. Belanger, Brittany M. Bowman, Leaf Huang, James E. Bear, Menglin Wang, Gabriella Yacovone, Alessandro Porrello, Emily B. Harrison, Sarah Cohen, Stephanie M. Cohen, Teresa M. Mascenik, Tyler J. Goodwin, Trent A. Waugh, Nicholas Mckenzie, Chad V. Pecot, Devon G. Allen, Ian A. Windham, Salma H. Azam, Amanda E.D. Van Swearingen, Michael B. Major, Pierre P. Massion, Subrata K. Ghosh
Publikováno v:
Cancer Res
Lung squamous carcinoma (LUSC) is a highly metastatic disease with a poor prognosis. Using an integrated screening approach, we found that miR-671-5p reduces LUSC metastasis by inhibiting a circular RNA (circRNA), CDR1as. Although the putative functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c669f3d321b66a7cf03a6ee9cc8668
https://europepmc.org/articles/PMC7669576/
https://europepmc.org/articles/PMC7669576/
Autor:
Shiho Chiba, Lisa E. Gralinski, Kenta Takahashi, Yixuan J. Hou, Caitlin E. Edwards, Richard C. Boucher, Teresa M. Mascenik, Noriko Nakajima, Yoshihiro Kawaoka, Scott H. Randell, Ralph S. Baric, Longping Tse, Tadaki Suzuki, Peter Halfmann, Makoto Kuroda, Camille Ehre, Sarah R. Leist, Alexandra Schäfer, Kenneth H. Dinnon, Rhianna E. Lee
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
The D614G substitution in the S protein is most prevalent SARS-CoV-2 strain circulating globally, but its effects in viral pathogenesis and transmission remain unclear. We engineered SARS-CoV-2 variants harboring the D614G substitution with or withou
Autor:
Gary L. Glish, Hong Dang, M. Lam, Teresa M. Mascenik, Scott H. Randell, John T. Minges, James E. Keating
Publikováno v:
C58. ACUTE LUNG INJURY: ATYPICAL TRIGGERS.
Autor:
Ling Sun, Richard C. Boucher, Alessandra Livraghi-Butrico, Purushothama Rao Tata, Kenichi Okuda, Luther A. Bartelt, Aravinda M. de Silva, Mark J. Cameron, Nathan I. Nicely, Adam J. Kimple, Ross E. Zumwalt, Andrew J. Ghio, Takanori Asakura, Hong Dang, Vishwaraj Sontake, Sarah R. Leist, David J. Kelvin, Alain C. Borczuk, Kenneth H. Dinnon, Kenneth N. Olivier, Longping V. Tse, Wanda K. O'Neal, Teresa M. Mascenik, M. Leslie Fulcher, Scott H. Randell, Caitlin E. Edwards, Takafumi Kato, Lisa E. Gralinski, Cheryl M. Cameron, David R. Martinez, Rodney C. Gilmore, Alexandra Schäfer, Ilona Jaspers, Yixuan J. Hou, Ralph S. Baric, Alena J. Markmann, Rhianna E. Lee, David M. Margolis, Steven P. Salvatore, Satoko Nakano, Gang Chen, Fernando J. Martinez, Boyd Yount
Publikováno v:
Cell
The mode of acquisition and causes for the variable clinical spectrum of coronavirus disease 2019 (COVID-19) remain unknown. We utilized a reverse genetics system to generate a GFP reporter virus to explore severe acute respiratory syndrome coronavir