Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Teresa M. Alvarez-Diez"'
Autor:
Matthew Campbell, Eddy Tan, Kerry White, Vito J. Palombella, Julian Adams, James M. Conley, Jennifer Hoyt, Martin R. Tremblay, Margit Hagel, Jens Sydor, Jeanne A. Ferguson, Jill Cushing, Alfredo C. Castro, Somarajan J. Nair, Andre Lescarbeau, Melissa Pink, Joseph D. Manna, Grogan Michael John, Margaret A. Read, Caroline N. Woodward, Grace Lin, Mark L. Behnke, Teresa M. Alvarez-Diez, Michael Curtis, Lin-Chen Yu, John R. MacDougall, Karen McGovern, Brian C. Austad
Publikováno v:
Journal of medicinal chemistry. 52(14)
Recent evidence suggests that blocking aberrant hedgehog pathway signaling may be a promising therapeutic strategy for the treatment of several types of cancer. Cyclopamine, a plant Veratrum alkaloid, is a natural product antagonist of the hedgehog p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2605d8d446344a594f8572549b6a22f4
https://pubmed.ncbi.nlm.nih.gov/19522463
https://pubmed.ncbi.nlm.nih.gov/19522463
Autor:
Jiang Zheng, Teresa M. Alvarez-Diez
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 32(12)
Earlier studies postulated that bioactivation of 4-ipomeanol by cytochrome P450 enzymes may occur through oxidation of its furan ring, following a mechanism similar to the bioactivation of other furan-containing compounds. This would lead to the form
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21e6716c33876134bbe01ce291e91c1a
https://pubmed.ncbi.nlm.nih.gov/15328249
https://pubmed.ncbi.nlm.nih.gov/15328249
Autor:
Teresa M. Alvarez-Diez, Jiang Zheng
Publikováno v:
Chemical research in toxicology. 17(2)
Earlier phase I and II clinical studies showed that 4-ipomeanol produced selective hepatotoxicity. To investigate the mechanism of bioactivation of 4-ipomeanol, we thoroughly studied the interaction of 4-ipomeanol with human cytochrome P450 3A4 (EC 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0934f69038b892c1d4ca376af4046d
https://pubmed.ncbi.nlm.nih.gov/14967002
https://pubmed.ncbi.nlm.nih.gov/14967002
Publikováno v:
Nuclear medicine and biology. 23(4)
Pretargeted tumour imaging was performed in nude mice bearing subcutaneous LS174T human colon cancer xenografts with streptavidin-CC49 monoclonal antibody and 111In-DTPA-biocytin. Mice were administered 250 micrograms of streptavidin-CC49, followed 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fcea20fc766c3075ffc49ad9a08541f
https://pubmed.ncbi.nlm.nih.gov/8832700
https://pubmed.ncbi.nlm.nih.gov/8832700
Autor:
Steven Gallinger, Teresa M. Alvarez-Diez, Jasbir Sandhu, Raymond M. Reilly, Joel A. Kirsh, Hartley Stern
Publikováno v:
Clinical pharmacokinetics. 28(2)
Monoclonal antibodies to tumour-associated antigens have great theoretical potential for the specific targeting of radioactivity and anti-neoplastic agents to tumours. The clinical success of monoclonal antibody-based cancer diagnosis and therapy dep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd146ed810f4d03ffa365c991846f0e3
https://pubmed.ncbi.nlm.nih.gov/7736688
https://pubmed.ncbi.nlm.nih.gov/7736688
Autor:
Martin R. Tremblay, André Lescarbeau, Michael J. Grogan, Eddy Tan, Grace Lin, Brian C. Austad, Lin-Chen Yu, Mark L. Behnke, Somarajan J. Nair, Margit Hagel, Kerry White, James Conley, Joseph D. Manna, Teresa M. Alvarez-Diez, Jennifer Hoyt, Caroline N. Woodward, Jens R. Sydor, Melissa Pink, John MacDougall, Matthew J. Campbell
Publikováno v:
Journal of Medicinal Chemistry; Jul2009, Vol. 52 Issue 14, p4400-4418, 19p