Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Teresa M Dunn"'
Autor:
Benjamin A Clarke, Saurav Majumder, Hongling Zhu, Y Terry Lee, Mari Kono, Cuiling Li, Caroline Khanna, Hailey Blain, Ronit Schwartz, Vienna L Huso, Colleen Byrnes, Galina Tuymetova, Teresa M Dunn, Maria L Allende, Richard L Proia
Publikováno v:
eLife, Vol 8 (2019)
Sphingolipids are membrane and bioactive lipids that are required for many aspects of normal mammalian development and physiology. However, the importance of the regulatory mechanisms that control sphingolipid levels in these processes is not well un
Externí odkaz:
https://doaj.org/article/2c0b70daaf154f68988f8dd68ab972c9
Autor:
Tian Xie, Feitong Dong, Gongshe Han, Xinyue Wu, Peng Liu, Zike Zhang, Jianlong Zhong, Somashekarappa Niranjanakumari, Kenneth Gable, Sita D. Gupta, Wenchen Liu, Peter J. Harrison, Dominic J. Campopiano, Teresa M. Dunn, Xin Gong
Publikováno v:
Cell Reports, Vol 43, Iss 2, Pp 113717- (2024)
Summary: The homeostatic regulation of serine palmitoyltransferase (SPT) activity in yeast involves N-terminal phosphorylation of Orm proteins, while higher eukaryotes lack these phosphorylation sites. Although recent studies have indicated a conserv
Externí odkaz:
https://doaj.org/article/448599eb4f234665b4c67e9c8c292f8a
Autor:
Peter J. Harrison, Kenneth Gable, Niranjanakumari Somashekarappa, Van Kelly, David J. Clarke, James H. Naismith, Teresa M. Dunn, Dominic J. Campopiano
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 5, Pp 953-962 (2019)
Isotope labels are frequently used tools to track metabolites through complex biochemical pathways and to discern the mechanisms of enzyme-catalyzed reactions. Isotopically labeled l-serine is often used to monitor the activity of the first enzyme in
Externí odkaz:
https://doaj.org/article/8d26d59fddb348eaad4afd29353dbd8f
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 3, Pp 475-483 (2019)
The sphingolipid (SL) metabolic pathway generates structurally diverse lipids that have roles as membrane constituents and as bioactive signaling molecules. The influence of the SL metabolic pathway in biology is pervasive; it exists in all mammalian
Externí odkaz:
https://doaj.org/article/12b1ef4136fd47a48e5939f75822d179
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Orosomucoid like 3 (ORMDL3) encodes an ER-resident transmembrane protein that regulates the activity of serine palmitoyltransferase (SPT), the first and rate-limiting enzyme for sphingolipid biosynthesis in cells. A decade ago, several genome wide as
Externí odkaz:
https://doaj.org/article/0e13a134144c4503ba08ab313806ffd8
Autor:
Peter J. Harrison, Kenneth Gable, Niranjanakumari Somashekarappa, Van Kelly, David J. Clarke, James H. Naismith, Teresa M. Dunn, Dominic J. Campopiano
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 8, Pp 1489- (2019)
Externí odkaz:
https://doaj.org/article/168d950b2bdd4100b099c78aba5d714b
Autor:
Peng Liu, Tian Xie, Xinyue Wu, Gongshe Han, Sita D. Gupta, Zike Zhang, Jian Yue, Feitong Dong, Kenneth Gable, Somashekarappa Niranjanakumari, Wanyuan Li, Lin Wang, Wenchen Liu, Ruifeng Yao, Edgar B. Cahoon, Teresa M. Dunn, Xin Gong
Publikováno v:
Science Advances. 9
The serine palmitoyltransferase (SPT) complex catalyzes the first and rate-limiting step in sphingolipid biosynthesis in all eukaryotes. ORM/ORMDL proteins are negative regulators of SPT that respond to cellular sphingolipid levels. However, the mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e928cd7f57bb33a9bb93ac5e9978d8c
https://doi.org/10.1126/sciadv.adg0728
https://doi.org/10.1126/sciadv.adg0728
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 4, Pp 898-908 (2015)
The ORM1 (Saccharomyces cerevisiae)-like proteins (ORMDLs) and their yeast orthologs, the Orms, are negative homeostatic regulators of the initiating enzyme in sphingolipid biosynthesis, serine palmitoyltransferase (SPT). Genome-wide association stud
Externí odkaz:
https://doaj.org/article/85ced00ad6244dbabb101329b2692921
Autor:
Aikaterini Alexaki, Sita D. Gupta, Saurav Majumder, Mari Kono, Galina Tuymetova, Jeffrey M. Harmon, Teresa M. Dunn, Richard L. Proia
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 12, Pp 2521-2531 (2014)
Sphingolipid levels are tightly regulated to maintain cellular homeostasis. During pathologic conditions such as in aging, inflammation, and metabolic and neurodegenerative diseases, levels of some sphingolipids, including the bioactive metabolite ce
Externí odkaz:
https://doaj.org/article/b14df911e5c248649fe18fc422222190
Autor:
Chiara Fiorillo, Giovanna Capodivento, Alessandro Geroldi, Stefano Tozza, Isabella Moroni, Payam Mohassel, Matteo Cataldi, Chiara Campana, Simone Morando, Chiara Panicucci, Marina Pedemonte, Noemi Brolatti, Sabrina Siliquini, Monica Traverso, Serena Baratto, Doriana Debellis, Stefania Magri, Valeria Prada, Emilia Bellone, Vincenzo Salpietro, Sandra Donkervoort, Kenneth Gable, Sita D. Gupta, Teresa M. Dunn, Carsten G. Bönnemann, Franco Taroni, Claudio Bruno, Angelo Schenone, Paola Mandich, Lucilla Nobbio, Maria Nolano
Publikováno v:
Neuropathology and Applied Neurobiology. 48
SPTLC1-related disorder is a late onset sensory-autonomic neuropathy associated with perturbed sphingolipid homeostasis which can be improved by supplementation with the serine palmitoyl-CoA transferase (SPT) substrate, l-serine. Recently, a juvenile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c0adef0de11c681ceab6cde003990b7
https://doi.org/10.1111/nan.12842
https://doi.org/10.1111/nan.12842