Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Teresa Lobo‐Jarne"'
1
Akademický článek
β‐Catenin activity induces an RNA biosynthesis program promoting therapy resistance in T‐cell acute lymphoblastic leukemia
Autor: Violeta García‐Hernández, David Arambilet, Yolanda Guillén, Teresa Lobo‐Jarne, María Maqueda, Christos Gekas, Jessica González, Arnau Iglesias, Nerea Vega‐García, Inés Sentís, Juan L Trincado, Ian Márquez‐López, Holger Heyn, Mireia Camós, Lluis Espinosa, Anna Bigas
Publikováno v: EMBO Molecular Medicine, Vol 15, Iss 2, Pp 1-17 (2023)
Abstract Understanding the molecular mechanisms that contribute to the appearance of chemotherapy resistant cell populations is necessary to improve cancer treatment. We have now investigated the role of β‐catenin/CTNNB1 in the evolution of T‐ce
Externí odkaz: https://doaj.org/article/6d549c35fe4041b3aab8286bb2e7461c
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2
Akademický článek
p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis
Autor: Laura Solé, Teresa Lobo-Jarne, Daniel Álvarez-Villanueva, Josune Alonso-Marañón, Yolanda Guillén, Marta Guix, Irene Sangrador, Catalina Rozalén, Anna Vert, Antonio Barbachano, Joan Lop, Marta Salido, Beatriz Bellosillo, Raquel García-Romero, Marta Garrido, Jessica González, María Martínez-Iniesta, Erika López-Arribillaga, Ramón Salazar, Clara Montagut, Ferrán Torres, Mar Iglesias, Toni Celià-Terrassa, Alberto Muñoz, Alberto Villanueva, Anna Bigas, Lluís Espinosa
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The failure of chemotherapy in colorectal cancer is currently unclear. Here, the authors show that upon sub-lethal dose of chemotherapy wild-type p53 colorectal cancers acquire a quiescence-like phenotype and a YAP-dependent fetal-like intestinal ste
Externí odkaz: https://doaj.org/article/a95e4335e7804b569fac9baa390c372b
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3
Akademický článek
Reversing chemorefraction in colorectal cancer cells by controlling mucin secretion
Autor: Gerard Cantero-Recasens, Josune Alonso-Marañón, Teresa Lobo-Jarne, Marta Garrido, Mar Iglesias, Lluis Espinosa, Vivek Malhotra
Publikováno v: eLife, Vol 11 (2022)
Fifteen percent of colorectal cancer (CRC) cells exhibit a mucin hypersecretory phenotype, which is suggested to provide resistance to immune surveillance and chemotherapy. We now formally show that CRC cells build a barrier to chemotherapeutics by i
Externí odkaz: https://doaj.org/article/f49320154f7d457ca1fef5ee8878bb15
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4
Akademický článek
Accumulation of Paneth Cells in Early Colorectal Adenomas Is Associated with Beta-Catenin Signaling and Poor Patient Prognosis
Autor: Erika López-Arribillaga, Bing Yan, Teresa Lobo-Jarne, Yolanda Guillén, Silvia Menéndez, Montserrat Andreu, Anna Bigas, Mar Iglesias, Lluís Espinosa
Publikováno v: Cells, Vol 10, Iss 11, p 2928 (2021)
Background: Previous studies in mice indicated that Paneth cells and c-Kit-positive goblet cells represent the stem cell niche of the small intestine and colon, respectively, partly by supporting Wnt and Notch activation. Whether these cell populatio
Externí odkaz: https://doaj.org/article/a2b2abc47bf94a33859ea7afe20bbba6
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5
Akademický článek
COX7A2L Is a Mitochondrial Complex III Binding Protein that Stabilizes the III2+IV Supercomplex without Affecting Respirasome Formation
Autor: Rafael Pérez-Pérez, Teresa Lobo-Jarne, Dusanka Milenkovic, Arnaud Mourier, Ana Bratic, Alberto García-Bartolomé, Erika Fernández-Vizarra, Susana Cadenas, Aitor Delmiro, Inés García-Consuegra, Joaquín Arenas, Miguel A. Martín, Nils-Göran Larsson, Cristina Ugalde
Publikováno v: Cell Reports, Vol 16, Iss 9, Pp 2387-2398 (2016)
Mitochondrial respiratory chain (MRC) complexes I, III, and IV associate into a variety of supramolecular structures known as supercomplexes and respirasomes. While COX7A2L was originally described as a supercomplex-specific factor responsible for th
Externí odkaz: https://doaj.org/article/57f6b2a6d31a4e268acc95b07dda5358
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6
Akademický článek
Human COX7A2L Regulates Complex III Biogenesis and Promotes Supercomplex Organization Remodeling without Affecting Mitochondrial Bioenergetics
Autor: Teresa Lobo-Jarne, Eva Nývltová, Rafael Pérez-Pérez, Alba Timón-Gómez, Thibaut Molinié, Austin Choi, Arnaud Mourier, Flavia Fontanesi, Cristina Ugalde, Antoni Barrientos
Publikováno v: Cell Reports, Vol 25, Iss 7, Pp 1786-1799.e4 (2018)
Summary: The mitochondrial respiratory chain is organized in a dynamic set of supercomplexes (SCs). The COX7A2L protein is essential for mammalian SC III2+IV assembly. However, its function in respirasome (SCs I+III2+IVn) biogenesis remains controver
Externí odkaz: https://doaj.org/article/fe2c9893ca9b4d149086a7d536dc5f1a
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10
Accumulation of paneth cells in early colorectal adenomas is associated with beta-catenin signaling and poor patient prognosis
Autor: Lluis Espinosa, Teresa Lobo-Jarne, Yolanda Guillén, Bing Yan, Mar Iglesias, Erika López-Arribillaga, Silvia Menendez, Montserrat Andreu, Anna Bigas
Publikováno v: Cells, Vol 10, Iss 2928, p 2928 (2021)
Cells; Volume 10; Issue 11; Pages: 2928
Cells
Background: Previous studies in mice indicated that Paneth cells and c-Kit-positive goblet cells represent the stem cell niche of the small intestine and colon, respectively, partly by supporting Wnt and Notch activation. Whether these cell populatio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::864539d8772734e80c40d212caa14533
http://hdl.handle.net/10230/53773
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