Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Teresa H. Vandekolk"'
Autor:
Alexandra Grubman, Xin Yi Choo, Gabriel Chew, John F. Ouyang, Guizhi Sun, Nathan P. Croft, Fernando J. Rossello, Rebecca Simmons, Sam Buckberry, Dulce Vargas Landin, Jahnvi Pflueger, Teresa H. Vandekolk, Zehra Abay, Yichen Zhou, Xiaodong Liu, Joseph Chen, Michael Larcombe, John M. Haynes, Catriona McLean, Sarah Williams, Siew Yeen Chai, Trevor Wilson, Ryan Lister, Colin W. Pouton, Anthony W. Purcell, Owen J. L. Rackham, Enrico Petretto, Jose M. Polo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Microglia associated with Aβ plaques may have a distinct transcriptional signature compared to those in plaque-free areas of the brain in Alzheimer’s disease (AD) models. Here the authors show that amyloid plaque phagocytosis is associated with a
Externí odkaz:
https://doaj.org/article/9f55b1d1d77043558956af5abec4909b
Autor:
Jon Merlin, Julia Park, Teresa H. Vandekolk, Stewart A. Fabb, Jeanne Allinne, Roger J. Summers, Christopher J. Langmead, Darren M. Riddy
Publikováno v:
Molecular Pharmacology. 101:246-256
Specialized proresolving mediators (SPMs) and their cognate G protein-coupled receptors are implicated in autoimmune disorders, including chronic inflammation, rheumatoid arthritis, systemic scleroderma, and lupus erythematosus. To date, six G protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c08cd0bcd602496d84d926505e97ea72
https://doi.org/10.1124/molpharm.121.000422
https://doi.org/10.1124/molpharm.121.000422
Autor:
Sarah J. Piper, Xin Zhang, Christopher J. Langmead, Patrick M. Sexton, Radostin Danev, Rachel M. Johnson, Teresa H. Vandekolk, Denise Wootten, Theodore J. Nettleton
Publikováno v:
Biochemical and Biophysical Research Communications. 578:84-90
Dual agonists that can activate both the glucagon-like peptide-1 receptor (GLP-1R) and the gastric inhibitory polypeptide receptor (GIPR) have demonstrated high efficacy for the treatment of metabolic disease. Peptide-19 is a prototypical dual agonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ac9a2f200cf87384e80ba3421a510a2
https://doi.org/10.1016/j.bbrc.2021.09.016
https://doi.org/10.1016/j.bbrc.2021.09.016
Autor:
Guizhi Sun, Jessica Hatwell-Humble, Šárka Lehtonen, Minna Oksanen, Jose M. Polo, Teresa H. Vandekolk, Jari Koistinaho, Colin W. Pouton, Alexandra Grubman, Jan Schröder, Cameron P.J. Hunt, Susan K. Nilsson, Jonathan M. Chan, John M. Haynes
Publikováno v:
Stem Cell Reports
Summary Multiple protocols have been published for generation of iMGLs from hESCs/iPSCs. To date, there are no guides to assist researchers to determine the most appropriate methodology for microglial studies. To establish a framework to facilitate f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8278175e2c91a4341b107e7021135729
https://doi.org/10.1016/j.stemcr.2020.04.007
https://doi.org/10.1016/j.stemcr.2020.04.007
Autor:
Christopher J. Langmead, Teresa H. Vandekolk, Jess Nithianantharajah, Cassandra J Hatzipantelis, Monica Langiu, Tracie L. Pierce, Gregory D. Stewart
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] There are no effective therapeutics for cognitive impairments associated with schizophrenia (CIAS), which includes deficits in executive functions (working memory and cognitive flexibility) and episodic memory. Compounds that have e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::914cd56aa1c79006e8a10eee2dcc7f79
https://pubmed.ncbi.nlm.nih.gov/33344888
https://pubmed.ncbi.nlm.nih.gov/33344888
Autor:
Wai-Ling Lieuw, Teresa H. Vandekolk, Sharon D. Ricardo, John M. Haynes, James N. Selby, Sheetal Saini, Joan K. Ho, Craig L. Fisher, Katie Leach, Isaiah P. L. Abad, Judith Savige
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 367:335-347
Renal podocyte survival depends upon the dynamic regulation of a complex cell architecture that links the glomerular basement membrane to integrins, ion channels, and receptors. Alport syndrome is a heritable chronic kidney disease where mutations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5ae8b41ca07a13892c5416185436d26
https://doi.org/10.1124/jpet.118.250142
https://doi.org/10.1124/jpet.118.250142
Autor:
Alexandra Grubman, Xiaodong Liu, Siew Yeen Chai, Owen J. L. Rackham, Sam Buckberry, Nathan P. Croft, Teresa H. Vandekolk, Rebecca K. Simmons, Ryan Lister, Gabriel Chew, Catriona McLean, John M. Haynes, Dulce Vargas Landin, Enrico Petretto, Fernando J. Rossello, Sarah M. Williams, Colin W. Pouton, Guizhi Sun, Jahnvi Pflueger, Zehra C. Abay, Xin Yi Choo, Trevor J Wilson, Jose M. Polo, Anthony W. Purcell, John F. Ouyang
The important role of microglia, the brain’s resident immune cells, in Alzheimer’s disease (AD) is now well recognized, however their molecular and functional diversity and underlying mechanisms still remain controversial. To transcriptionally an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e60b4e08261434c296359eacb3545aa6
