Výsledky vyhledávání - "Teresa Gomez‐Isla"

Akademický článek

Portable, low-field magnetic resonance imaging for evaluation of Alzheimer’s disease

Autor: Annabel J. Sorby-Adams, Jennifer Guo, Pablo Laso, John E. Kirsch, Julia Zabinska, Ana-Lucia Garcia Guarniz, Pamela W. Schaefer, Seyedmehdi Payabvash, Adam de Havenon, Matthew S. Rosen, Kevin N. Sheth, Teresa Gomez-Isla, J. Eugenio Iglesias, W. Taylor Kimberly

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)

Abstract Portable, low-field magnetic resonance imaging (LF-MRI) of the brain may facilitate point-of-care assessment of patients with Alzheimer’s disease (AD) in settings where conventional MRI cannot. However, image quality is limited by a lower

Externí odkaz: https://doaj.org/article/b2c8789335704ba3b379080d32787e96

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Akademický článek

Plasma biomarkers for diagnosis of Alzheimer's disease and prediction of cognitive decline in individuals with mild cognitive impairment

Publikováno v: Frontiers in Neurology, Vol 14 (2023)

BackgroundThe last few years have seen major advances in blood biomarkers for Alzheimer's Disease (AD) with the development of ultrasensitive immunoassays, promising to transform how we diagnose, prognose, and track progression of neurodegenerative d

Externí odkaz: https://doaj.org/article/6404f04c0c8f4fdea79ffcc9b0fb11c5

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Akademický článek

Autoradiography validation of novel tau PET tracer [F-18]-MK-6240 on human postmortem brain tissue

Autor: Cinthya Aguero, Maeva Dhaynaut, Marc D. Normandin, Ana C. Amaral, Nicolas J. Guehl, Ramesh Neelamegam, Marta Marquie, Keith A. Johnson, Georges El Fakhri, Matthew P. Frosch, Teresa Gomez-Isla

Publikováno v: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-15 (2019)

Abstract [F-18]-MK-6240, a novel tau positron emission tomography (PET) tracer recently discovered for the in vivo detection of neurofibrillary tangles, has the potential to improve diagnostic accuracy in the detection of Alzheimer disease. We have e

Externí odkaz: https://doaj.org/article/c17455142d6d417a93810cff5500cd94

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Akademický článek

Distinct cytokine profiles in human brains resilient to Alzheimer's pathology

Publikováno v: Neurobiology of Disease, Vol 121, Iss , Pp 327-337 (2019)

Our group has previously studied the brains of some unique individuals who are able to tolerate robust amounts of Alzheimer's pathological lesions (amyloid plaques and neurofibrillary tangles) without experiencing dementia while alive. These rare res

Externí odkaz: https://doaj.org/article/fb448af25f8c45e29b685fb3b437ea3f

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Akademický článek

Isoform-selective decrease of glycogen synthase kinase-3-beta (GSK-3β) reduces synaptic tau phosphorylation, transcellular spreading, and aggregation

Autor: Ana Claudia Amaral, Beatriz G. Perez-Nievas, Michael Siao Tick Chong, Alicia Gonzalez-Martinez, Herminia Argente-Escrig, Sara Rubio-Guerra, Caitlin Commins, Serra Muftu, Bahareh Eftekharzadeh, Eloise Hudry, Zhanyun Fan, Prianca Ramanan, Shuko Takeda, Matthew P. Frosch, Susanne Wegmann, Teresa Gomez-Isla

Publikováno v: iScience, Vol 24, Iss 2, Pp 102058- (2021)

Summary: It has been suggested that aberrant activation of glycogen synthase kinase-3-beta (GSK-3β) can trigger abnormal tau hyperphosphorylation and aggregation, which ultimately leads to neuronal/synaptic damage and impaired cognition in Alzheimer

Externí odkaz: https://doaj.org/article/0834daf1f0d14cb1bd40b2f5ea69e654

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Projection of Care Partners’ Preferences in the Proxy Assessments of Everyday Preferences for Persons With Cognitive Impairment

Autor: James M, Wilkins, Joseph J, Locascio, Teresa, Gomez-Isla, Bradley T, Hyman, Deborah, Blacker, Brent P, Forester, Olivia I, Okereke

Publikováno v: The American Journal of Geriatric Psychiatry. 31:254-263

Bias in surrogate decision-making can occur when proxy decision-makers overestimate the degree to which their preferences are shared by others, resulting in a projection of their beliefs onto others. The purpose of this study is to assess projection

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1d287bc08d63090f9797a78e34f6019
https://doi.org/10.1016/j.jagp.2022.12.005

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Predictors of the importance of everyday preferences for older adults with cognitive impairment

Autor: Joseph J. Locascio, James M. Wilkins, Bradley T. Hyman, Jeanette Gunther, Deborah Blacker, Teresa Gomez-Isla, Liang Yap, Brent P. Forester, Olivia I. Okereke

Publikováno v: Int Psychogeriatr

Objectives:Among older people with cognitive impairment and mild dementia, relatively little is known about the factors that predict preferences for everyday living activities and experiences and that influence the relative importance of those activi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b473cb7ba0b122536e6fc661b082c1
https://doi.org/10.1017/s1041610220003956

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Longitudinal differences in everyday preferences: Comparisons between people with cognitive impairment and their care partners

Autor: Deborah Blacker, James M. Wilkins, Bradley T. Hyman, Teresa Gomez-Isla, Jeanette Gunther, Joseph J. Locascio, Olivia I. Okereke, Brent P. Forester

Publikováno v: Int J Geriatr Psychiatry

Objectives Persons with progressive cognitive impairment (CI) increasingly rely on surrogate decision-makers for everyday activities. Yet, little is known about changes in everyday preferences over time or about concordance between persons with CI an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d12d8ff337ff7b55120c5a47f82c53c7
https://doi.org/10.1002/gps.5620

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