Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Teresa G, Cachero"'
Autor:
Graham K. Farrington, Jessica E. Friedman, Joshua C. Yoburn, Alexey Lugovskoy, William Michael Flanagan, Stephan K. Miller, Brian C. Cunningham, Amy D. Fung, Adrian Whitty, Molly M. He, Jun Wang, Annemarie Stroustrup Smith, Mark T. Cancilla, John Eldredge, Leslie A. Cruz, Johan D. Oslob, Teresa G. Cachero, Andrew C. Braisted, Eric S. Day, Ingrid C. Choong
Publikováno v:
Science. 310:1022-1025
We have identified a small-molecule inhibitor of tumor necrosis factor α (TNF-α) that promotes subunit disassembly of this trimeric cytokine family member. The compound inhibits TNF-α activity in biochemical and cell-based assays with median inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a6ce3328b91c59024e2eaf119ff3ef0
https://doi.org/10.1126/science.1116304
https://doi.org/10.1126/science.1116304
Autor:
Dingyi Wen, Adrian Whitty, Marc Pelletier, Fang Qian, Yaping Sun, Yen-Ming Hsu, Teresa G. Cachero, Eric S. Day
Publikováno v:
Biochemistry. 44:1919-1931
BAFF (B cell activating factor of the TNF family, also known as BlyS and TALL-1), a TNF family cytokine critical for the development and function of B cells, has been reported to bind to three receptors, BCMA (B cell maturation protein), TACI (transm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e4800bcedc124bcec34625cb6ca4fa6
https://doi.org/10.1021/bi048227k
https://doi.org/10.1021/bi048227k
Autor:
Sarah A. Bixler, Christine Ambrose, Yen-Ming Hsu, Jeffrey Thompson, Adrian Whitty, Teresa G. Cachero, Eric S. Day, Christopher D. Benjamin, Mohammad Zafari, Fang Qian, Marc Pelletier, Susan L. Kalled, Leonid Gorelik, Kevin Gilbride, Dahai Gong
Publikováno v:
Journal of Biological Chemistry. 278:33127-33133
BAFF is considered a therapeutic target because dysregulated production of BAFF can induce systemic lupus erythematosus-like phenotype in mice, and elevated levels of BAFF are associated with disease severity in systemic lupus erythematosus and rheum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd0241b43fd9025878d9da657035183
https://doi.org/10.1074/jbc.m305754200
https://doi.org/10.1074/jbc.m305754200
Autor:
Yen-Ming Hsu, Ann Boriack-Sjodin, Teresa G. Cachero, Colleen Mullen, Fang Qian, Kathy Strauch, Susan L. Kalled, Michael Karpusas
Publikováno v:
Journal of Molecular Biology. 315:1145-1154
B cell activating factor (BAFF), a ligand belonging to the tumor necrosis factor (TNF) family, plays a critical role in regulating survival and activation of peripheral B cell populations and has been associated with autoimmune disease. BAFF is known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4bb02dffbfb9f8f972da38e13692498
https://doi.org/10.1006/jmbi.2001.5296
https://doi.org/10.1006/jmbi.2001.5296
Autor:
Joanna Groom, Susan L. Kalled, Anne H. Cutler, Carl Olson, Stephen A. Woodcock, Pascal Schneider, Jurg Tschopp, Teresa G. Cachero, Marcel Batten, Julie Wheway, Davide Mauri, Dana Cavill, Tom P. Gordon, Charles R. Mackay, Fabienne Mackay
Publikováno v:
Journal of Clinical Investigation. 109:59-68
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0f8ea62dd9fb573ccbc7bc7cfe00684
https://doi.org/10.1172/jci0214121
https://doi.org/10.1172/jci0214121
Autor:
Christopher D. Benjamin, Sarah A. Bixler, Kalpit Vora, Jürg Tschopp, Jeffrey Thompson, Christine Ambrose, Catherine Hession, Martin L. Scott, Jeffrey L. Browning, Irene Sizing, Kathy Strauch, Mohammad Zafari, Pascal Schneider, Fang Qian, Teresa G. Cachero, Colleen Mullen
Publikováno v:
Science. 293:2108-2111
B cell homeostasis has been shown to critically depend on BAFF, the B cell activation factor from the tumor necrosis factor (TNF) family. Although BAFF is already known to bind two receptors, BCMA and TACI, we have identified a third receptor for BAF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c3f49fedd3f751eedb5fd6d3b5f79ec
https://doi.org/10.1126/science.1061965
https://doi.org/10.1126/science.1061965
Autor:
Jeffrey Thompson, Sylvie Hertig, Jürg Tschopp, Jeffrey L. Browning, Kathy Strauch, Teresa G. Cachero, Luciana Trabach, Fang Qian, Christine Ambrose, Pascal Schneider, Colleen Mullen, Nils Holler, Paul Rennert
Publikováno v:
The Journal of Experimental Medicine
Journal of Experimental Medicine, vol. 192, no. 11, pp. 1677-1684
Journal of Experimental Medicine, vol. 192, no. 11, pp. 1677-1684
A proliferation-inducing ligand (APRIL) is a ligand of the tumor necrosis factor (TNF) family that stimulates tumor cell growth in vitro and in vivo. Expression of APRIL is highly upregulated in many tumors including colon and prostate carcinomas. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1b8b36932df694cc315beea9bc3993f
https://doi.org/10.1084/jem.192.11.1677
https://doi.org/10.1084/jem.192.11.1677
Publikováno v:
Cell. 93:1077-1085
Tyrosine kinases activated by G protein–coupled receptors can phosphorylate and thereby suppress the activity of the delayed rectifier potassium channel Kv1.2. Using a yeast two-hybrid screen, we identified the small GTP-binding protein RhoA as a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d38fcc348172bae32e46dcd25c60b908
https://doi.org/10.1016/s0092-8674(00)81212-x
https://doi.org/10.1016/s0092-8674(00)81212-x
Publikováno v:
Proceedings of the National Academy of Sciences. 95:5051-5056
Several G protein-coupled receptors are known to direct the tyrosine phosphorylation, and in some cases the activation, of diverse tyrosine kinases. Using a stable cell line approach, we characterize the activation of PYK2, a tyrosine kinase structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf720e78e47dab871cd6beaae8bd188
https://doi.org/10.1073/pnas.95.9.5051
https://doi.org/10.1073/pnas.95.9.5051
Autor:
Pascal Schneider, Hans Acha-Orbea, Martin L. Scott, Helen Leung, Elodie Belnoue, Claire-Anne Siegrist, Aubry Tardivel, Karine Ingold, Jürg Tschopp, Fabienne Mackay, Teresa G. Cachero, Claudia Bossen, Aris Maquelin, Laure Willen, Max Dobles, Stéphane Chevrier
Publikováno v:
Blood, vol. 111, no. 3, pp. 1004-1012
Blood, Vol. 111, No 3 (2008) pp. 1004-12
Blood, Vol. 111, No 3 (2008) pp. 1004-12
The cytokine BAFF binds to the receptors TACI, BCMA, and BAFF-R on B cells, whereas APRIL binds to TACI and BCMA only. The signaling properties of soluble trimeric BAFF (BAFF 3-mer) were compared with those of higher-order BAFF oligomers. All forms o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::845fdc6130975cc2c39ad9a1bce2d88b
https://pubmed.ncbi.nlm.nih.gov/17942754
https://pubmed.ncbi.nlm.nih.gov/17942754