Na+/H+ Exchanger Regulatory Factor Isoform 1 Overexpression Modulates Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Expression and Activity in Human Airway 16HBE14o- Cells and Rescues ΔF508 CFTR Functional Expression in Cystic Fibrosis Cells*

Autor: Stephan J. Reshkin, Salvatore Carrabino, Valeria Casavola, Stefania Maria Riccardi, Rosa Angela Cardone, Giovanni Busco, Edward J. Weinman, Maria Favia, Massimo Conese, Teresa Fanelli, Lorenzo Guerra

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2005, 280 (49), pp.40925-40933. ⟨10.1074/jbc.M505103200⟩

There is evidence that cystic fibrosis transmembrane conductance regulator (CFTR) interacting proteins play critical roles in the proper expression and function of CFTR. The Na(+)/H(+) exchanger regulatory factor isoform 1 (NHERF1) was the first iden

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7963059a1268d14c90ae733aff473e43
https://doi.org/10.1074/jbc.m505103200

Na+/H+ exchanger regulatory factor 1 overexpression-dependent increase of cytoskeleton organization is fundamental in the rescue of F508del cystic fibrosis transmembrane conductance regulator in human airway CFBE41o- cells

Autor: Stefania Monterisi, Francesca Di Sole, Rosa Angela Cardone, Maria Favia, Stephan J. Reshkin, Ursula Seidler, Valeria Casavola, Massimo Conese, Teresa Fanelli, Stefano Castellani, Mingmin Chen, Lorenzo Guerra

Publikováno v: Molecular Biology of the Cell

NHERF1 overexpression increases functional apical expression of F508del CFTR in CFBE41o- cells. Here, we show that this occurs via the formation of the multiprotein complex NHERF1-phosphoezrin-actin, which provides a regulated linkage between F508del

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c44f003834e4afca3ecdc06d5c8f494b
https://pubmed.ncbi.nlm.nih.gov/19889841

NHE3 inhibits PKA-dependent functional expression of CFTR by NHERF2 PDZ interactions

Autor: P. G. Suh, F. Di Sole, Teresa Fanelli, Maria Favia, Anna Bagorda, Stephan J. Reshkin, Valeria Casavola, Lorenzo Guerra

Publikováno v: Biochemical and biophysical research communications. 347(2)

It has been shown that when CFTR and NHE3 are co-expressed on the apical membrane of the A6-NHE3 cell monolayers, the two transporters interact via a shared regulatory complex composed of NHERF2, ezrin, and PKA. We observe here that co-expression of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23101b18ab7893c7dff468b75c340209
https://pubmed.ncbi.nlm.nih.gov/16824484

EZRIN PHOSPHORYLATION AND ACTIVATION OF RHOA PLAY A ROLE IN THE RESCUE OF ΔF508CFTR IN CFBE41O– CELLS BY NHERF1

Autor: R.A. Cardone, Sj Reshkin, Teresa Fanelli, S.M. Riccardi, Maria Favia, Massimo Conese, Valeria Casavola, Lorenzo Guerra

Publikováno v: Journal of Cystic Fibrosis. 7:S18-S19

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::125dadac80945d6af5b81a22b18c9d1a

β-Oestradiol rescues ΔF508CFTR functional expression in human cystic fibrosis airway CFBE41o− cells through the up-regulation of NHERF1.

Autor: Teresa Fanelli, Rosa Angela Cardone, Maria Favia, Lorenzo Guerra, Manuela Zaccolo, Stefania Monterisi, Teresa De santis, Stefania Maria Riccardi, Stephan Joel Reshkin, Valeria Casavola

Publikováno v: Biology of the Cell (Wiley-Blackwell); 2008, Vol. 100 Issue 7, p399-412, 14p