Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Teresa F. Burke"'
Autor:
Sheng-Bin Peng, Richard P. Beckmann, James J. Starling, Edward M. Chan, Sean G. Buchanan, Youyan Zhang, Robert D. Van Horn, Lysiane Huber, Teresa F. Burke, Vipin Yadav
Supplementary figure S1 describes the molecular mechanisms of resistance across vemurafenib-resistant cell line models. Supplementary figure S2 serves as a repeat of figure 3a describing development of in vivo model of resistance, and demonstrates th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10bd36236a130dcd815e4329a2a4012f
https://doi.org/10.1158/1535-7163.22501512.v1
https://doi.org/10.1158/1535-7163.22501512.v1
Autor:
Xueqian Gong, Wenjuan Wu, Youyan Zhang, R.D. Van Horn, S-H Chen, Richard P. Beckmann, Sean Buchanan, Phillip W Iversen, Lysiane Huber, Teresa F. Burke, Tinggui Yin, Ramon V. Tiu, Shripad V. Bhagwat, S-B Peng, Jason Manro
Publikováno v:
Oncogene. 37:821-832
KRAS, NRAS and BRAF mutations are among the most important oncogenic drivers in many major cancer types, such as melanoma, lung, colorectal and pancreatic cancer. There is currently no effective therapy for the treatment of RAS mutant cancers. LY3009
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a1037c2c823ec0676981822a09dfd4
https://doi.org/10.1038/onc.2017.384
https://doi.org/10.1038/onc.2017.384
Autor:
Palaniappan Kulanthaivel, Richard P. Beckmann, Damien M. Cronier, Sonya C. Tate, Teresa F. Burke, Daisy G Hartman
Publikováno v:
British Journal of Cancer
Background: Resistance to BRAF inhibition is a major cause of treatment failure for BRAF-mutated metastatic melanoma patients. Abemaciclib, a cyclin-dependent kinase 4 and 6 inhibitor, overcomes this resistance in xenograft tumours and offers a promi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c88dc63ff5a179fd1f9c61989884e903
http://europepmc.org/articles/PMC4800303
http://europepmc.org/articles/PMC4800303
Autor:
Constance King, David Anthony Barda, Mark S. Marshall, H. Bruce Diaz, Darlene S. Barnard, Bonita D. Jones, Gregory P. Donoho, Richard P. Beckmann, Teresa F. Burke
Publikováno v:
Investigational New Drugs. 34:49-60
Pharmacological inhibition of CHK1 in the absence of p53 functionality leads to abrogation of the S and G2/M DNA damage checkpoints. We report the preclinical therapeutic activity of LY2603618 (CHK1 inhibitor) at inhibiting CHK1 activation by gemcita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::544e6cd03ce7a15575cf14dace2a5626
https://doi.org/10.1007/s10637-015-0310-y
https://doi.org/10.1007/s10637-015-0310-y
Autor:
Sonya C. Tate, Rose T. Ajamie, Richard P. Beckmann, Damien M. Cronier, Teresa F. Burke, Shufen Cai, Graham N. Wishart, Alfonso De Dios, Edward M. Chan, Lawrence M. Gelbert
Publikováno v:
Clinical Cancer Research. 20:3763-3774
Purpose: Selective inhibition of cyclin-dependent kinases 4 and 6 (CDK4/6) represents a promising therapeutic strategy. However, despite documented evidence of clinical activity, limited information is available on the optimal dosing strategy of CDK4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::287f63bd24dd066247305109a62c4c16
https://doi.org/10.1158/1078-0432.ccr-13-2846
https://doi.org/10.1158/1078-0432.ccr-13-2846
Autor:
Emmanuel S. Onaivi, Georgianna G. Gould, Ting Ting Gu, Corey M. Smolik, Teresa F. Burke, Miguel D. Osorio, Wynne Q. Zhang, Mauris N. DeSilva, Julie G. Hensler
Publikováno v:
Psychoneuroendocrinology. 39:158-169
Hypothalamic pituitary adrenal (HPA) axis responses to change and social challenges during adolescence can influence mental health and behavior into adulthood. To examine how HPA tone in adolescence may contribute to psychopathology, we challenged ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd09bcb85de5da9a431d77a8b231231
https://doi.org/10.1016/j.psyneuen.2013.09.003
https://doi.org/10.1016/j.psyneuen.2013.09.003
Publikováno v:
Synapse. 67:648-655
We have recently demonstrated that, in C57/Bl6 mice, long-term voluntary wheel running is anxiogenic, and focal hippocampal irradiation prevents the increase in anxiety-like behaviors and neurobiological changes in the hippocampus induced by wheel ru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c546c1429f923e8ca3d63355d30ff7c
https://doi.org/10.1002/syn.21666
https://doi.org/10.1002/syn.21666
Publikováno v:
Neurotherapeutics. 9:477-485
Depression represents a common comorbidity of epilepsy and is frequently resistant to selective serotonin reuptake inhibitors (SSRI). We tested the hypothesis that the SSRI resistance in epilepsy associated depression may be a result of a pathologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::babd6d9255784f6050d869d626d405ac
https://doi.org/10.1007/s13311-012-0110-4
https://doi.org/10.1007/s13311-012-0110-4
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 340:19-26
This study examined the positive modulatory properties of 2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one (rac-BHFF) at γ-aminobutyric acid B (GABA(B))
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac20ae25f58bd4ccf03db6f4fcea719b
https://doi.org/10.1124/jpet.111.186577
https://doi.org/10.1124/jpet.111.186577
Publikováno v:
Neuropsychopharmacology. 36:1305-1316
Depression is a common comorbidity of temporal lobe epilepsy and has highly negative impact on patients' quality of life. We previously established that pilocarpine-induced status epilepticus (SE) in rats, concurrently with chronic epilepsy leads to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb6ed876681c6ed926121849b8e0dce0
https://doi.org/10.1038/npp.2011.18
https://doi.org/10.1038/npp.2011.18