Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Teresa Ezponda"'
Autor:
Guillermo Serrano, Nerea Berastegui, Aintzane Díaz-Mazkiaran, Paula García-Olloqui, Carmen Rodriguez-Res, Sofia Huerga-Dominguez, Marina Ainciburu, Amaia Vilas-Zornoza, Patxi San Martin-Uriz, Paula Aguirre-Ruiz, Asier Ullate-Agote, Beñat Ariceta, Jose-Maria Lamo-Espinosa, Pamela Acha, Oriol Calvete, Tamara Jimenez, Antonieta Molero, Maria Julia Montoro, Maria Díez-Campelo, David Valcarcel, Francisco Solé, Ana Alfonso-Pierola, Idoia Ochoa, Felipe Prósper, Teresa Ezponda, Mikel Hernaez
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract While myelodysplastic syndromes with del(5q) (del(5q) MDS) comprises a well-defined hematological subgroup, the molecular basis underlying its origin remains unknown. Using single cell RNA-seq (scRNA-seq) on CD34+ progenitors from del(5q) MD
Externí odkaz:
https://doaj.org/article/91536052d5734ebda987ce77dddb892b
Autor:
Nerea Berastegui, Marina Ainciburu, Juan P. Romero, Paula Garcia-Olloqui, Ana Alfonso-Pierola, Céline Philippe, Amaia Vilas-Zornoza, Patxi San Martin-Uriz, Raquel Ruiz-Hernández, Ander Abarrategi, Raquel Ordoñez, Diego Alignani, Sarai Sarvide, Laura Castro-Labrador, José M. Lamo-Espinosa, Mikel San-Julian, Tamara Jimenez, Félix López-Cadenas, Sandra Muntion, Fermin Sanchez-Guijo, Antonieta Molero, Maria Julia Montoro, Bárbara Tazón, Guillermo Serrano, Aintzane Diaz-Mazkiaran, Mikel Hernaez, Sofía Huerga, Findlay Bewicke-Copley, Ana Rio-Machin, Matthew T. Maurano, María Díez-Campelo, David Valcarcel, Kevin Rouault-Pierre, David Lara-Astiaso, Teresa Ezponda, Felipe Prosper
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Myelodysplastic syndromes (MDS) are age-related pathologies in which alterations of hematopoietic stem cells lead to abnormal formation of blood cells. Here, the authors study the lesions that these cells undergo in aging and disease, characterizing
Externí odkaz:
https://doaj.org/article/5a52f5ed769d4553afa3673e2f1e7052
Autor:
Jianhao Peng, Guillermo Serrano, Ian M. Traniello, Maria E. Calleja-Cervantes, Ullas V. Chembazhi, Sushant Bangru, Teresa Ezponda, Juan Roberto Rodriguez-Madoz, Auinash Kalsotra, Felipe Prosper, Idoia Ochoa, Mikel Hernaez
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-19 (2022)
SimiC, a single-cell gene regulatory inference framework is presented that can infer multiple gene regulatory networks across related cell phenotypes, unraveling complex regulatory dynamics.
Externí odkaz:
https://doaj.org/article/fa439cbcedcc415a9f8c9bea20c8ce19
Autor:
Marina Ainciburu, Teresa Ezponda, Nerea Berastegui, Ana Alfonso-Pierola, Amaia Vilas-Zornoza, Patxi San Martin-Uriz, Diego Alignani, Jose Lamo-Espinosa, Mikel San-Julian, Tamara Jiménez-Solas, Felix Lopez, Sandra Muntion, Fermin Sanchez-Guijo, Antonieta Molero, Julia Montoro, Guillermo Serrano, Aintzane Diaz-Mazkiaran, Miren Lasaga, David Gomez-Cabrero, Maria Diez-Campelo, David Valcarcel, Mikel Hernaez, Juan P Romero, Felipe Prosper
Publikováno v:
eLife, Vol 12 (2023)
Early hematopoiesis is a continuous process in which hematopoietic stem and progenitor cells (HSPCs) gradually differentiate toward specific lineages. Aging and myeloid malignant transformation are characterized by changes in the composition and regu
Externí odkaz:
https://doaj.org/article/3e9c063b4a474f658aaf2538b69955f6
Autor:
Teresa Ezponda, Daphné Dupéré-Richer, Christine M. Will, Eliza C. Small, Nobish Varghese, Tej Patel, Behnam Nabet, Relja Popovic, Jon Oyer, Marinka Bulic, Yupeng Zheng, Xiaoxiao Huang, Mrinal Y. Shah, Sayantan Maji, Alberto Riva, Manuela Occhionorelli, Giovanni Tonon, Neil Kelleher, Jonathan Keats, Jonathan D. Licht
Publikováno v:
Cell Reports, Vol 21, Iss 3, Pp 628-640 (2017)
Loss or inactivation of the histone H3K27 demethylase UTX occurs in several malignancies, including multiple myeloma (MM). Using an isogenic cell system, we found that loss of UTX leads to deactivation of gene expression ultimately promoting the prol
Externí odkaz:
https://doaj.org/article/c8e4f4dce46b4e28975494365da80fbf
Autor:
Behnam Nabet, Pilib Ó Broin, Jaime M. Reyes, Kevin Shieh, Charles Y. Lin, Christine M. Will, Relja Popovic, Teresa Ezponda, James E. Bradner, Aaron A. Golden, Jonathan D. Licht
Publikováno v:
Cell Reports, Vol 12, Iss 8, Pp 1300-1313 (2015)
Unrestrained receptor tyrosine kinase (RTK) signaling and epigenetic deregulation are root causes of tumorigenesis. We establish linkage between these processes by demonstrating that aberrant RTK signaling unleashed by oncogenic HRasG12V or loss of n
Externí odkaz:
https://doaj.org/article/d46a0408c3ce460aa11345d0ea1375f4
Autor:
Relja Popovic, Eva Martinez-Garcia, Eugenia G Giannopoulou, Quanwei Zhang, Qingyang Zhang, Teresa Ezponda, Mrinal Y Shah, Yupeng Zheng, Christine M Will, Eliza C Small, Youjia Hua, Marinka Bulic, Yanwen Jiang, Matteo Carrara, Raffaele A Calogero, William L Kath, Neil L Kelleher, Ji-Ping Wang, Olivier Elemento, Jonathan D Licht
Publikováno v:
PLoS Genetics, Vol 10, Iss 9, p e1004566 (2014)
Overexpression of the histone methyltransferase MMSET in t(4;14)+ multiple myeloma patients is believed to be the driving factor in the pathogenesis of this subtype of myeloma. MMSET catalyzes dimethylation of lysine 36 on histone H3 (H3K36me2), and
Externí odkaz:
https://doaj.org/article/293a2a508f7f439b86ca58f29cbbee55
Autor:
Hannah Armes, Findlay Bewicke‐Copley, Ana Rio‐Machin, Doriana Di Bella, Céline Philippe, Anna Wozniak, Hemanth Tummala, Jun Wang, Teresa Ezponda, Felipe Prosper, Inderjeet Dokal, Tom Vulliamy, Outi Kilpivaara, Ulla Wartiovaara‐Kautto, Jude Fitzgibbon, Kevin Rouault‐Pierre
Publikováno v:
British Journal of Haematology. 199:754-764
Despite the inclusion of inherited myeloid malignancies as a separate entity in the World Health Organization Classification, many established predisposing loci continue to lack functional characterization. While germline mutations in the DNA repair
Autor:
Luis M. Montuenga, Ruben Pio, Wenceslao Torre, José M. López-Picazo, José I. Echeveste, Jackeline Agorreta, María J. Pajares, Teresa Ezponda
Supplementary Figures S1-S3 and Supplementary Tables S1-S2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dceb350f98ba65b200416fe701b30b2
https://doi.org/10.1158/1078-0432.22442988.v1
https://doi.org/10.1158/1078-0432.22442988.v1
Autor:
Ana Rio-Machin, Findlay Bewicke-Copley, Jiexin Zheng, Pedro Casado Izquierdo, Juho J. Miettinen, Naeem Khan, Jonas Demeulemeester, Szilvia Krizsán, Christopher Middleton, Sam Benkwitz-Bedford, Joseph Saad, Amaia Vilas-Zornoza, Teresa Ezponda, William Grey, Vincent-Philippe Lavallée, Alexis Nolin-Lapalme, Farideh Miraki-Moud, Janet Matthews, Marianne Grantham, Ryan J Colm, Jonathan Bond, Doriana Di Bella, Krister Wennerberg, Alun Parsons, Andy G.X. Zeng, Hannah Armes, Karina Close, Fadimana Kaya, Kevin Rouault-Pierre, John G. Gribben, Felipe Prosper, James Cavenagh, John E. Dick, Sylvie D Freeman, Peter Van Loo, Csaba Bödör, Guy Sauvageau, Kimmo Porkka, Caroline A. Heckman, Jun Wang, Jean-Baptiste Cazier, David Taussig, Dominique Bonnet, Pedro Cutillas, Jude Fitzgibbon
Publikováno v:
Blood. 140:1030-1032