Tyrosine Kinase Inhibitors. 20. Optimization of Substituted Quinazoline and Pyrido[3,4-d]pyrimidine Derivatives as Orally Active, Irreversible Inhibitors of the Epidermal Growth Factor Receptor Family

Autor: Patricia J. Harvey, Gonzales Andrea, Shannon Leigh Black, Jeff B. Smaill, Ken Hook, Florence O. McCarthy, Stephen Fakhoury, Adrian Blaser, Haile Tecle, Freddy Rivault, Tong Zhu, Brian D. Palmer, Kevin Matthew Schlosser, Jessica Elizabeth Reed, Karen Elaine Sexton, William A. Denny, Irene W. Althaus, R. Thomas Winters, Teresa Ellis, Helen Tsenwhei Lee, Andrew M. Thompson, Erin Trachet, Alexander James Bridges, Julie Ann Spicer, Paul A. Ellis

Publikováno v: Journal of Medicinal Chemistry. 59:8103-8124

Structure-activity relationships for inhibition of erbB1, erbB2, and erbB4 were determined for a series of quinazoline- and pyrido[3,4-d]pyrimidine-based analogues of the irreversible pan-erbB inhibitor, canertinib. Cyclic amine bearing crotonamides

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e41b02b5002130f3f1a0856c03fbdf
https://doi.org/10.1021/acs.jmedchem.6b00883

Presentation abstracts

Autor: Laura, Rice, JongHun, Sung, Kathleen, Keane, Elizabeth, Peterson, Jacob, Sosnoff, Gary, Farkas, Ann, Swartz, Scott, Strath, Ashraf, Gorgey, Arthur, Berg, David, Gater, Trevor, Dyson-Hudson, Gerard, Malanga, Chris, Cherian, Monica, Michalec, Steven, Kirshblum, Carrie, Miller, Kristin, Garlanger, Sam, Kortes, Alyssa, Schnorenberg, Brooke, Slavens, Kenneth, Lee, Kelsey, Potter-Baker, Frederick, Frost, Ela, Plow, Ryan, Solinsky, Catherine, Wilson, Carrie Ann, Henry, Alexander, Lombard, Matthew, Maher, Joseph, Weir, Sana, Saeed, Christopher, Cirnigliaro, Adam, Specht, Erica, Garbarini, Jonathan, Augustine, Gail, Forrest, William, Bauman, Jill, Wecht, Jasmine, Hearn, Imaduddin S, Razvi, Seema, Sikka, Librada, Callender, Monica, Bennett, Keston, Robertson, Simon, Driver, Cristina, Kline-Quiroz, Jayne, Donovan, Amanda, Botticello, Dannae, Arnold, Nancy, Latham, Bethlyn, Houlihan, Timothy, Bickmore, Ha, Trinh, Ameneh, Shamekhi, Teresa, Ellis, Sherri L, LaVela, Elizabeth, Burkhart, Ibuola, Kale, Charles, Bombardier, Ellen, Snoxell, Steven, Knezevic, EunKyoung, Hong, Pierre, Asselin, Stephen, Kornfeld, Peter, Gorman, Ann, Spungen, Camilo, Castillo, Christine, Cleveland, Joelle, Gabet, Amanda, Harrington, Patricia, Arenth, David, Dolbow, Stephen, Luther, Dezon, Finch, Lina, Bouayad, Marcel, Kopp, Ralf, Watzlawick, Peter, Martus, Vieri, Failli, Felix, Finkenstaedt, Yuying, Chen, Michael, DeVivo, Ulrich, Dirnagl, Jan, Schwab, James, LiMonta, Tiffany, Santiago, Yu-Kuang, Wu, Noam, Harel, Kimberley, Monden, Zina, Trost, Nguyen, Nguyen, Leslie, Morse, Adriel, Boals, Lisa, Wenzel, Stephanie, Silveira, Rosemary, Hughes, Margaret, Nosek, Tracey, LeDoux, Heather, Taylor, Lauren, Diaz, Susan, Robinson-Whelen, Eric, Garshick, Kendra, Betz, James, Krause, Yue, Cao, Chao, Li, Beverly, Hon, Cria-May, Khong, Ben, Dirlikov, Kazuko, Shem, Susan, Charlifue, Shawn, Song, Stephen, Burns

Publikováno v: The journal of spinal cord medicine. 41(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9e1fa748ec5d5fe1a0f48a65aa48b31f
https://pubmed.ncbi.nlm.nih.gov/30132748

Effect of human cerebrospinal fluid sampling frequency on amyloid‐β levels

Autor: Robert A. Lenz, Jinhe Li, Teresa Ellis, Anahita Bhathena, David LeBlond, Daniel A. Llano, Jeffrey F. Waring, Larry Ereshefsky, Stanford Jhee

Publikováno v: Alzheimer's & Dementia. 8:295-303

Background β-amyloid peptide (Aβ) is associated with neurodegeneration in Alzheimer's disease. Emerging evidence indicates that Aβ levels in cerebrospinal fluid (CSF) may serve as an early clinical biomarker for evaluating pharmacological activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75ab013fe13dbddccef27bff943cc4e6
https://doi.org/10.1016/j.jalz.2011.05.900

Comparing levels of biochemical markers in CSF from cannulated and non-cannulated rats

Autor: Uwe Müller, Teresa Ellis, Wayne R. Buck, Bradley A. Hooker, Ann Tovcimak, Nathan R. Rustay, Steven C. Cassar, Dancia Scharf, Jeffrey F. Waring, Kevin K.W. Wang, Jinhe Li, Andreas Jeromin, David G. Witte

Publikováno v: Journal of Neuroscience Methods. 192:249-253

Cerebrospinal fluid (CSF) is commonly used for assessing biomarkers of drug efficacy or disease progression in the central nervous system. Studies of CSF from pre-clinical species can characterize biomarkers for use in clinical trials. However, obtai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d20be3623bbb2039516b3b170c718bbe
https://doi.org/10.1016/j.jneumeth.2010.07.042

The Relationship between Different Assays for Detection and Quantification of Amyloid Beta 42 in Human Cerebrospinal Fluid

Autor: Teresa Ellis, Jinhe Li, David LeBlond, Jeffrey F. Waring

Publikováno v: International Journal of Alzheimer's Disease, Vol 2012 (2012)
International Journal of Alzheimer's Disease

Alzheimer's disease (AD), which is characterized by a degeneration of neurons and their synapses, is one of the most common forms of dementia. CSF levels of amyloid 𝛽 4 2 (A 𝛽 4 2 ) have been recognized as a strong candidate to serve as an AD b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45bd4df1af9eda055e0a0ee21c73f217
https://doaj.org/article/da170786e3a54dcba726a367bc945751