Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Teresa C. Dugger"'
Autor:
Luigi Formisano, Yao Lu, Alberto Servetto, Ariella B. Hanker, Valerie M. Jansen, Joshua A. Bauer, Dhivya R. Sudhan, Angel L. Guerrero-Zotano, Sarah Croessmann, Yan Guo, Paula Gonzalez Ericsson, Kyung-min Lee, Mellissa J. Nixon, Luis J. Schwarz, Melinda E. Sanders, Teresa C. Dugger, Marcelo Rocha Cruz, Amir Behdad, Massimo Cristofanilli, Aditya Bardia, Joyce O’Shaughnessy, Rebecca J. Nagy, Richard B. Lanman, Nadia Solovieff, Wei He, Michelle Miller, Fei Su, Yu Shyr, Ingrid A. Mayer, Justin M. Balko, Carlos L. Arteaga
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Era+ breast cancer patients often develop resistance to endocrine therapy. Here, the authors show that FGFR1 amplification is a resistance mechanism to CDK4/6 inhibitor and endocrine therapy and that combined treatment with FGFR, CDK4/6, and anti-est
Externí odkaz:
https://doaj.org/article/c9a8bb9c2aac44dba476758c76c4a8d4
Autor:
Carlos L. Arteaga, Craig W. Lindsley, J. Phillip Kennedy, Rebecca S. Cook, Archana Narasanna, Nara de Matos Granja, Teresa C. Dugger, Violeta Sanchez, Maria G. Olivares, H. Charles Manning, Shelby K. Wyatt, Chirayu Shah, James T. Forbes, Todd W. Miller
Supplementary Data from Inhibition of Mammalian Target of Rapamycin Is Required for Optimal Antitumor Effect of HER2 Inhibitors against HER2-Overexpressing Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::653c8b21d3c6a201c988ec0973ac57a0
https://doi.org/10.1158/1078-0432.22440382
https://doi.org/10.1158/1078-0432.22440382
Autor:
Carlos L. Arteaga, Erik S. Knudsen, Wenyi Wei, Teresa C. Dugger, David A. Riddle, Michael J. Pishvaian, Paula R. Pohlmann, Melinda E. Sanders, Paula G. Ericsson, Violeta Sánchez, Mónica Valéria Estrada, Preston D. Moore, Agnieszka K. Witkiewicz, Katherine E. Hutchinson, Kyung-Min Lee, Luigi Formisano, Joshua A. Bauer, Neil E. Bhola, Valerie M. Jansen
Acquired resistance to cyclin-dependent kinases 4 and 6 (CDK4/6) small-molecule inhibitors in breast cancer arises through mechanisms that are yet uncharacterized. In this study, we used a kinome-wide siRNA screen to identify kinases that, when downr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::878135b809b1f085cc62987f886868e5
https://doi.org/10.1158/0008-5472.c.6509882.v1
https://doi.org/10.1158/0008-5472.c.6509882.v1
Autor:
Carlos L. Arteaga, Craig W. Lindsley, J. Phillip Kennedy, Rebecca S. Cook, Archana Narasanna, Nara de Matos Granja, Teresa C. Dugger, Violeta Sanchez, Maria G. Olivares, H. Charles Manning, Shelby K. Wyatt, Chirayu Shah, James T. Forbes, Todd W. Miller
Purpose: A significant fraction of HER2-overexpressing breast cancers exhibit resistance to the HER2 antibody trastuzumab. Hyperactivity of the phosphatidylinositol 3-kinase (PI3K)/AKT pathway confers trastuzumab resistance, and mammalian target of r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a00d9dac82eb35707c35f191fbcf914d
https://doi.org/10.1158/1078-0432.c.6517720
https://doi.org/10.1158/1078-0432.c.6517720
Autor:
Carlos L. Arteaga, Erik S. Knudsen, Wenyi Wei, Teresa C. Dugger, David A. Riddle, Michael J. Pishvaian, Paula R. Pohlmann, Melinda E. Sanders, Paula G. Ericsson, Violeta Sánchez, Mónica Valéria Estrada, Preston D. Moore, Agnieszka K. Witkiewicz, Katherine E. Hutchinson, Kyung-Min Lee, Luigi Formisano, Joshua A. Bauer, Neil E. Bhola, Valerie M. Jansen
Supplementary Figure S1. RNAi screen to identify kinases that sensitize cells to CDK4/6 inhibition. Supplementary Figure S2. Calculation of the sensitivity index (SI) value. Supplementary Figure S3. PDK1 and CDK4/6 inhibitors are synergistic against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad87a39fc7665994129ea46a0e522f6a
https://doi.org/10.1158/0008-5472.22417598.v1
https://doi.org/10.1158/0008-5472.22417598.v1
Autor:
Carlos L. Arteaga, Erik S. Knudsen, Wenyi Wei, Teresa C. Dugger, David A. Riddle, Michael J. Pishvaian, Paula R. Pohlmann, Melinda E. Sanders, Paula G. Ericsson, Violeta Sánchez, Mónica Valéria Estrada, Preston D. Moore, Agnieszka K. Witkiewicz, Katherine E. Hutchinson, Kyung-Min Lee, Luigi Formisano, Joshua A. Bauer, Neil E. Bhola, Valerie M. Jansen
Supplementary Materials and Methods and Figure Legends for Supplementary Figures S1-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af58ae1fd4d3e24d6c5e617f0e03c98
https://doi.org/10.1158/0008-5472.22417595.v1
https://doi.org/10.1158/0008-5472.22417595.v1
Autor:
Carlos L. Arteaga, Eliezer V. Allen, Teresa C. Dugger, Melinda Sanders, Fei Ye, Vandana Abramson, Ingrid Mayer, Ingrid Meszoely, Mónica V. Estrada, Justin M. Balko, Jennifer M. Giltnane, Sangeeta Bafna, Valerie M. Jansen, Neil E. Bhola
Supplementary Figure S5. PLK1 targeting decreases the expression of ER signaling genes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3cc4c1937cd27d19a1f776085069220
https://doi.org/10.1158/0008-5472.22404660
https://doi.org/10.1158/0008-5472.22404660
Autor:
Carlos L. Arteaga, Eliezer V. Allen, Teresa C. Dugger, Melinda Sanders, Fei Ye, Vandana Abramson, Ingrid Mayer, Ingrid Meszoely, Mónica V. Estrada, Justin M. Balko, Jennifer M. Giltnane, Sangeeta Bafna, Valerie M. Jansen, Neil E. Bhola
Supplementary Table S2. siRNAs identified to decrease cell proliferation, ER transcription and both in the RNAi screen of MCF7/LTED cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::943072b07fd27689bb15f09cb00b770c
https://doi.org/10.1158/0008-5472.22404648.v1
https://doi.org/10.1158/0008-5472.22404648.v1
Autor:
Carlos L. Arteaga, Eliezer V. Allen, Teresa C. Dugger, Melinda Sanders, Fei Ye, Vandana Abramson, Ingrid Mayer, Ingrid Meszoely, Mónica V. Estrada, Justin M. Balko, Jennifer M. Giltnane, Sangeeta Bafna, Valerie M. Jansen, Neil E. Bhola
Supplementary Table and Figure Legends. Legends for Supplementary Tables S1-S2 and Supplementary Figures S1-S6.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a5c30db50e3f4d62175af131c233074
https://doi.org/10.1158/0008-5472.22404645
https://doi.org/10.1158/0008-5472.22404645
Autor:
Carlos L. Arteaga, Eliezer V. Allen, Teresa C. Dugger, Melinda Sanders, Fei Ye, Vandana Abramson, Ingrid Mayer, Ingrid Meszoely, Mónica V. Estrada, Justin M. Balko, Jennifer M. Giltnane, Sangeeta Bafna, Valerie M. Jansen, Neil E. Bhola
Supplementary Methods and References. Description of additional methods and procedures used in the study. Also includes Supplementary References.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e214528cba67563ae82c26839af242
https://doi.org/10.1158/0008-5472.22404654
https://doi.org/10.1158/0008-5472.22404654