Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Teresa Andreani"'
Autor:
Eric B. Sirota, Aaron M. Whittaker, David J. Lamberto, Teresa Andreani, Thomas Kwok, Eric Margelefsky, Scott Quirie, Varsolona Richard J
Publikováno v:
Organic Process Research & Development. 25:308-317
Islatravir (MK-8591), a highly potent nucleoside reverse transcriptase translocation inhibitor, is being developed to stem the spread of global HIV infections. Following a nine-enzyme in vitro synt...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a633a726dbd887f39963702e59e767a
https://doi.org/10.1021/acs.oprd.0c00520
https://doi.org/10.1021/acs.oprd.0c00520
Autor:
Xiao Wang, Justin A. Newman, Aaron M. Whittaker, Heather C. Johnson, Teresa Andreani, Kevin M. Maloney, Niki R. Patel, Mark A. Huffman, Mark McLaughlin, Bangwei Ding
Publikováno v:
Chemistry – A European Journal. 26:14118-14123
A 5-step enantioselective synthesis of the potent anti-HIV nucleoside islatravir is reported. The highly efficient route was enabled by a novel enantioselective alkynylation of an α,β-unsaturated ketone, a unique ozonolysis-dealkylation cascade in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ad69882d0d18454dffc9164ce24b67
https://doi.org/10.1002/chem.202003091
https://doi.org/10.1002/chem.202003091
Autor:
Mark A. Huffman, Yingju Xu, Aaron M. Whittaker, Kevin M. Maloney, Teresa Andreani, David M. Tschaen, Andrew Brunskill, François Lévesque, Hongming Li, Christopher C. Nawrat, Mark McLaughlin, Hao Yang, Anna Fryszkowska, Niki R. Patel
Publikováno v:
Organic letters. 22(12)
The synthesis of the potent anti-HIV investigational treatment islatravir is described. The key step in this synthesis is a highly enantioselective catalytic asymmetric alkynylation of a ketone. This reaction is a rare example of the asymmetric addit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8866cb9f28b97cbbb694b890f24515f1
https://pubmed.ncbi.nlm.nih.gov/32516536
https://pubmed.ncbi.nlm.nih.gov/32516536
Autor:
Charles Lee Jayne, Santhosh Neelamkavil, Alan Hruza, Richard N. Ingram, Samuel Chackalamannil, Mariappan V. Chelliah, Keith Eagen, Teresa Andreani, William J. Greenlee, Kartik M. Keertikar, Steve Fried, Brian Hawes, Yan Xia, Zhuyan Guo, Michael P. Dwyer, Tin-Yau Chan, Paul Reichert, Martin C. Clasby
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(15)
The synthesis and structure activity relationship development of a pyrimidine series of heterocyclic Factor IXa inhibitors is described. Increased selectivity over Factor Xa inhibition was achieved through SAR expansion of the P1 element. Select comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c095f071ef48433855bcea54d91788f5
https://pubmed.ncbi.nlm.nih.gov/32527459
https://pubmed.ncbi.nlm.nih.gov/32527459
Autor:
Mark Weisel, Hongming Li, Teresa Andreani, Christopher C. Nawrat, Aaron M. Whittaker, David M. Tschaen, Mark A. Huffman, Ryan D. Cohen, Mark McLaughlin, Bangwei Ding
Publikováno v:
Organic letters. 22(6)
A stereoselective nine-step synthesis of the potent HIV nucleoside reverse transcriptase translocation inhibitor (NRTTI) islatravir (EfdA, MK-8591) from 2-deoxyribose is described. Key findings include a diastereodivergent addition of an acetylide nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e04dea89c93801ec7898043b5b4056f
https://pubmed.ncbi.nlm.nih.gov/32108487
https://pubmed.ncbi.nlm.nih.gov/32108487
Autor:
Teresa Andreani
Publikováno v:
Bioethica. 7:40
In the last three decades, the dilemma of End-of-Life is one of the most disputed bio-juridical questions Italy is confronting with. By raising highly sensitive ethical, legal and political dilemmas, it has deeply divided the Italian society, the sci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba88ecc41a01a30dbc57efce03c933de
https://doi.org/10.12681/bioeth.28158
https://doi.org/10.12681/bioeth.28158
Autor:
Katrina W. Lexa, Daniel A. DiRocco, Zhijian Liu, Cheol K. Chung, Rebecca T. Ruck, Yining Ji, Teresa Andreani, Guy R. Humphrey, Yingju Xu
Publikováno v:
Journal of the American Chemical Society. 139:10637-10640
A weak Bronsted acid-catalyzed asymmetric guanidine aza-conjugate addition reaction has been developed. C2-symmetric, dual hydrogen-bond donating bistriflamides are shown to be highly effective in activating α,β-unsaturated esters toward the intram
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::598afcd8a949fdf466122fd904a75248
https://doi.org/10.1021/jacs.7b05806
https://doi.org/10.1021/jacs.7b05806
Autor:
John S. Edwards, Teresa Andreani, Michael Williams, Hongmei Li, Jongrock Kong, Peter R. Mullens, Brian C. Bishop, Ed Cleator, Adrian Goodyear, Michael J. Zacuto, Yan Jin, Mark McLaughlin
Publikováno v:
Organic Process Research & Development. 20:1075-1087
Two new routes to a pyrimidyl tetrazole intermediate are described. The first-generation route featured an iron-catalyzed cross-coupling between 4-butenylmagnesium bromide and a 4-chloropyrimidine derivative to afford an alkene-bearing pyrimidine int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5d61592180531de92bc4c27b0895e0f
https://doi.org/10.1021/acs.oprd.6b00136
https://doi.org/10.1021/acs.oprd.6b00136
Autor:
Michael Shevlin, Melodie Christensen, Bangping Xiang, Michael R. Luzung, David M. Tschaen, Teresa Andreani, Stephen M. Dalby, Guy R. Humphrey, Zhiguo Jake Song, Kevin M. Belyk
Publikováno v:
Organic Process Research & Development. 20:1097-1103
The development of a concise asymmetric synthesis of the antiviral development candidate letermovir is reported, proceeding in >60% yield over a total of seven steps from commercially available materials. Key to the effectiveness of this process is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbb7d845915ca1bcfb4ba89e7076fb2c
https://doi.org/10.1021/acs.oprd.6b00076
https://doi.org/10.1021/acs.oprd.6b00076
Autor:
Aaron M. Whittaker, Teresa Andreani, Niki R. Patel, Mark A. Huffman, Bangwei Ding, Heather C. Johnson, Kevin M. Maloney, Justin A. Newman, Mark McLaughlin, Xiao Wang
Publikováno v:
Chemistry – A European Journal. 26:14023-14023
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53eae7bb26afbe2d059e0dd7bb5d5f70
https://doi.org/10.1002/chem.202003600
https://doi.org/10.1002/chem.202003600