Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Teresa Aja"'
Autor:
Teresa Aja, Giovanni Roxas, Nancy Tryder, Carlos F. Barbas, Curt Bradshaw, Mysore P. Ramprasad, Francesca Fang Liao, Lingna Li, David A. Griffith, Venkata Doppalapudi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:501-506
Aryl sulfonamide-based endothelin antagonists were synthesized and covalently linked to the reactive lysine of the m38C2 antibody to create a series of CovX-Bodies. These chemically programmed antibodies behaved as potent endothelin receptor antagoni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::004f3f7faa5d353622e71914c9200338
https://doi.org/10.1016/j.bmcl.2006.10.009
https://doi.org/10.1016/j.bmcl.2006.10.009
Autor:
Kevin J. Tomaselli, Julia Herrmann, Robert O. Sayers, Joe C. Wu, Lalitha Kodandapani, Kathy G. Jahangiri, Craig D. Fisher, David T. Winn, Edward D. Robinson, Steven P. Meduna, Robert J. Ternansky, Pauline Yeo, Karen L. Valentino, Jose-Luis Diaz, Vincent J. Kalish, Steven D. Linton, Kristen Sebring, Robert A. Armstrong, Joseph F. Krebs, Niel C. Hoglen, Alfred P. Spada, Brad P. Hirakawa, Ning Chen, Brett R. Ullman, Brett Weylan Ching, Cheng-zhi Zhang, Xu Bai, Xin Gu, Kip Nalley, Long-Shiuh Chen, Patricia L. Gladstone, Jeff McQuiston, Teresa Aja, Todd Groessl, Donald S. Karanewsky, Suzanne Weeks, Lawrence C. Fritz, Patricia C. Contreras
Publikováno v:
Journal of Medicinal Chemistry. 48:6779-6782
A series of oxamyl dipeptides were optimized for pan caspase inhibition, anti-apoptotic cellular activity and in vivo efficacy. This structure-activity relationship study focused on the P4 oxamides and warhead moieties. Primarily on the basis of in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc05f6b9f812322c1ff557485178cfdb
https://doi.org/10.1021/jm050307e
https://doi.org/10.1021/jm050307e
Autor:
Robert Smidt, Silvio Roggo, Julia Herrmann, Edward D. Robinson, Kathy G. Jahangiri, Teresa Aja, Kip Nalley, Thomas L. Deckwerth, Giorgio Rovelli, Kevin J. Tomaselli, Joe C. Wu, Bastian Hengerer, Steven P. Meduna, André Sauter, Jose-Luis Diaz, Joerg Kallen, Albert Schmitz, Donald S. Karanewsky, Brett R. Ullman, Steven D. Linton, Christoph Wiessner, Robert J. Ternansky, Peter R. Allegrini, Robert O. Sayers
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:2685-2691
Structural modifications were made to a previously described acyl dipeptide caspase inhibitor, leading to the oxamyl dipeptide series. Subsequent SAR studies directed toward the warhead, P2, and P4 regions of this novel peptidomimetic are described h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb680f6d4dacf778afb32ec56f318e3
https://doi.org/10.1016/j.bmcl.2003.12.106
https://doi.org/10.1016/j.bmcl.2003.12.106
Autor:
Edward D. Robinson, Silvio Roggo, Joe C. Wu, Robert J. Ternansky, Jose-Luis Diaz, Teresa Aja, Kevin J. Tomaselli, Steven P. Meduna, Vincent J. Kalish, Donald S. Karanewsky, Robert O. Sayers, Albert Schmitz, Brett R. Ullman, Julia Herrmann, Kip Nalley, Thomas L. Deckwerth
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3623-3626
Various aryloxy methyl ketones of the 1-naphthyloxyacetyl-Val-Asp backbone have been prepared. A systematic study of their structure-activity relationship (SAR) related to caspases 1, 3, 6, and 8 is reported. Highly potent irreversible broad-spectrum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681ec055be84e31c81b8947185e1442d
https://doi.org/10.1016/s0960-894x(03)00755-8
https://doi.org/10.1016/s0960-894x(03)00755-8
Autor:
Teresa Aja, André Sauter, Donald S. Karanewsky, Markus Rudin, Rachel May, Peter R. Allegrini, Bastian Hengerer, Robert O. Sayers, Christoph Wiessner, Steve Linton, Albert Schmitz, Giorgio Rovelli, Kevin J. Tomaselli, Patricia C. Contreras, Joe C. Wu, Silvio Roggo, Kip Nalley, Lisa M. Adams, Thomas L. Deckwerth
Publikováno v:
Drug Development Research. 52:579-586
Apoptotic cell death occurs in the injured and diseased central nervous system. It is mediated by a family of caspases, which are activated by the lethal stimulus and cleave multiple protein substrates that are critical for cell viability. Previous s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa9ad16436d7f28cc9622c6484c77710
https://doi.org/10.1002/ddr.1161
https://doi.org/10.1002/ddr.1161
Autor:
Christian Leist, Kim Hoang, Anu Srinivasan, Donald S. Karanewsky, Tam Vu, Lawrence C. Fritz, Robert C. Armstrong, Joe C. Wu, Bryan Pham, Teresa Aja, Rob Sayers, Albert Schmitz, Angela M. Wong, Joseph F. Krebs, Aileen Aboy, Kevin J. Tomaselli
Publikováno v:
The Journal of Cell Biology
The mechanism by which membrane-bound Bcl-2 inhibits the activation of cytoplasmic procaspases is unknown. Here we characterize an intracellular, membrane-associated form of procaspase-3 whose activation is controlled by Bcl-2. Heavy membranes isolat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789f6e636e676d741d6d8f50362f45a9
https://doi.org/10.1083/jcb.144.5.915
https://doi.org/10.1083/jcb.144.5.915
Autor:
Kevin J. Tomaselli, Smita Gaur, Emad S. Alnemri, Teresa Aja, Donald S. Karanewsky, Xu Bai, Kim Hoang, Robert C. Armstrong, Gerald Litwack, Lawrence C. Fritz
Publikováno v:
The Journal of Neuroscience. 17:553-562
Neuronal apoptosis occurs during nervous system development and after pathological insults to the adult nervous system. Inhibition of CED3/ICE-related proteases has been shown to inhibit neuronal apoptosisin vitroandin vivo, indicating a role for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db1bee7fc57d62d2812e35934ac24105
https://doi.org/10.1523/jneurosci.17-02-00553.1997
https://doi.org/10.1523/jneurosci.17-02-00553.1997
Autor:
Joseph F. Krebs, Jialing Xiang, Smita Gaur, Lawrence C. Fritz, Xu Bai, Kevin J. Tomaselli, Stanley J. Korsmeyer, Teresa Aja, Donald S. Karanewsky, Robert C. Armstrong, Kim Hoang
Publikováno v:
Journal of Biological Chemistry. 271:16850-16855
The human proto-oncogene bcl-2 and its Caenorhabditis elegans homologue ced-9 inhibit programmed cell death. In contrast, members of the human interleukin-1beta converting enzyme (ICE) family of cysteine proteases and their C. elegans homologue CED-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc541b7846591585e609d45b148ec91
https://doi.org/10.1074/jbc.271.28.16850
https://doi.org/10.1074/jbc.271.28.16850
Autor:
Teresa Aja, Kevin J. Tomaselli, Edward D. Robinson, Joe C. Wu, Steven D. Linton, Xin Gu, Robert O. Sayers, Steven P. Meduna, Kip Nalley, Lalitha Kodandapani, Silvio Roggo, Vincent J. Kalish, Jose-Luis Diaz, Donald S. Karanewsky, Ning Chen, Albert Schmitz, Julia Herrmann, Brett R. Ullman, Joseph J. Krebs, Robert J. Ternansky
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(15)
Various heterocyclic hetero-methyl ketones of the 1-naphthyloxyacetyl-Val-Asp backbone have been prepared. A study of their structure-activity relationship (SAR) related to caspase-1, -3, -6, and -8 is reported. Their efficacy in a cellular model of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d20fa9b2635d713c24eee1115cb07fa3
https://pubmed.ncbi.nlm.nih.gov/15964758
https://pubmed.ncbi.nlm.nih.gov/15964758