Estrogen Receptor Beta Agonist Influences Presynaptic NMDA Receptor Distribution in the Paraventricular Hypothalamic Nucleus Following Hypertension in a Mouse Model of Perimenopause

Autor: Garrett Sommer, Claudia Rodríguez López, Adi Hirschkorn, Gianna Calimano, Jose Marques-Lopes, Teresa A. Milner, Michael J. Glass

Publikováno v: Biology, Vol 13, Iss 10, p 819 (2024)

Women become susceptible to hypertension as they transition to menopause (i.e., perimenopause); however, the underlying mechanisms are unclear. Animal studies using an accelerated ovarian failure (AOF) model of peri-menopause (peri-AOF) demonstrate t

Externí odkaz: https://doaj.org/article/7b3ee53683a74a96b1364086402dff9d

State-of-the-art review of the clinical research on menopause and hormone replacement therapy association with Parkinson’s disease: What meta-analysis studies cannot tell us

Autor: Santiago R. Unda, Sabina Marciano, Teresa A. Milner, Roberta Marongiu

Publikováno v: Frontiers in Aging Neuroscience, Vol 14 (2022)

The menopause is a midlife endocrinological process that greatly affects women’s central nervous system functions. Over the last 2 decades numerous clinical studies have addressed the influence of ovarian hormone decline on neurological disorders l

Externí odkaz: https://doaj.org/article/703a6d3c3a304df69a8f5c9f2dbd9d4f

Sex and chronic stress alter the distribution of glutamate receptors within rat hippocampal CA3 pyramidal cells following oxycodone conditioned place preference

Autor: Alexandra Dolgetta, Megan Johnson, Kate Fruitman, Luke Siegel, Yan Zhou, Bruce S. McEwen, Mary Jeanne Kreek, Teresa A. Milner

Publikováno v: Neurobiology of Stress, Vol 17, Iss , Pp 100431- (2022)

Glutamate receptors have a key role in the neurobiology of opioid addiction. Using electron microscopic immunocytochemical methods, this project elucidates how sex and chronic immobilization stress (CIS) impact the redistribution of GluN1 and GluA1 w

Externí odkaz: https://doaj.org/article/3b28b44451fd4c55ade536f5155b4a41

Parkin is a disease modifier in the mutant SOD1 mouse model of ALS

Autor: Gloria M Palomo, Veronica Granatiero, Hibiki Kawamata, Csaba Konrad, Michelle Kim, Andrea J Arreguin, Dazhi Zhao, Teresa A Milner, Giovanni Manfredi

Publikováno v: EMBO Molecular Medicine, Vol 10, Iss 10, Pp 1-22 (2018)

Abstract Mutant Cu/Zn superoxide dismutase (SOD1) causes mitochondrial alterations that contribute to motor neuron demise in amyotrophic lateral sclerosis (ALS). When mitochondria are damaged, cells activate mitochondria quality control (MQC) mechani

Externí odkaz: https://doaj.org/article/aaf81c0436db4a92818ffa16bf842948

Single-nuclei isoform RNA sequencing unlocks barcoded exon connectivity in frozen brain tissue

Autor: Simon A. Hardwick, Wen Hu, Anoushka Joglekar, Li Fan, Paul G. Collier, Careen Foord, Jennifer Balacco, Samantha Lanjewar, Maureen McGuirk Sampson, Frank Koopmans, Andrey D. Prjibelski, Alla Mikheenko, Natan Belchikov, Julien Jarroux, Anne Bergstrom Lucas, Miklós Palkovits, Wenjie Luo, Teresa A. Milner, Lishomwa C. Ndhlovu, August B. Smit, John Q. Trojanowski, Virginia M. Y. Lee, Olivier Fedrigo, Steven A. Sloan, Dóra Tombácz, M. Elizabeth Ross, Erich Jarvis, Zsolt Boldogkői, Li Gan, Hagen U. Tilgner

Publikováno v: Nature Biotechnology, 40(7), 1082-1092. Nature Publishing Group
Hardwick, S A, Hu, W, Joglekar, A, Fan, L, Collier, P G, Foord, C, Balacco, J, Lanjewar, S, Sampson, M M G, Koopmans, F, Prjibelski, A D, Mikheenko, A, Belchikov, N, Jarroux, J, Lucas, A B, Palkovits, M, Luo, W, Milner, T A, Ndhlovu, L C, Smit, A B, Trojanowski, J Q, Lee, V M Y, Fedrigo, O, Sloan, S A, Tombácz, D, Ross, M E, Jarvis, E, Boldogkői, Z, Gan, L & Tilgner, H U 2022, ' Single-nuclei isoform RNA sequencing unlocks barcoded exon connectivity in frozen brain tissue ', Nature Biotechnology, vol. 40, no. 7, pp. 1082-1092 . https://doi.org/10.1038/s41587-022-01231-3

Single-nuclei RNA sequencing characterizes cell types at the gene level. However, compared to single-cell approaches, many single-nuclei cDNAs are purely intronic, lack barcodes and hinder the study of isoforms. Here we present single-nuclei isoform

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f086b2331c75eade283b32db9e2f0b
https://hdl.handle.net/1871.1/133d60c1-4a56-4cd6-98f3-fbc172b0ebeb