Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Teresa Órpez"'
Autor:
Carlos López-Gómez, Almudena Pino-Ángeles, Teresa Órpez-Zafra, María Jesús Pinto-Medel, Begoña Oliver-Martos, Jesús Ortega-Pinazo, Carlos Arnáiz, Cristina Guijarro-Castro, Jezabel Varadé, Roberto Álvarez-Lafuente, Elena Urcelay, Francisca Sánchez-Jiménez, Óscar Fernández, Laura Leyva
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62540 (2013)
TRAIL and TRAIL Receptor genes have been implicated in Multiple Sclerosis pathology as well as in the response to IFN beta therapy. The objective of our study was to evaluate the association of these genes in relation to the age at disease onset (AAO
Externí odkaz:
https://doaj.org/article/d9bde3f20f874475b3683c47a0d04621
Autor:
Begoña Oliver-Martos, Isaac Hurtado-Guerrero, Teresa Órpez-Zafra, Oscar Fernández, Laura Leyva, Xavier Montalban, María Jesús Pinto-Medel, Jose Luis Rodriguez Bada, Margarita Suardíaz, José C. Álvarez-Cermeño, Luisa M. Villar, Manuel Comabella, Patricia Urbaneja, José Pavia
Publikováno v:
Multiple Sclerosis Journal. 23:937-945
Background: The soluble isoform of the interferon-β (IFN-β) receptor (sIFNAR2) could modulate the activity of both endogenous and systemically administered IFN-β. Previously, we described lower serum sIFNAR2 levels in untreated multiple sclerosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfcd3aac1101a4d043fe90c259e6fc95
https://doi.org/10.1177/1352458516667564
https://doi.org/10.1177/1352458516667564
Autor:
María Jesús Pinto-Medel, Begoña Oliver-Martos, Carmen Marín-Bañasco, Carlos Arnáiz-Urrutia, Oscar Fernandez, Laura Leyva, G. Luque, Juan Antonio García-León, Teresa Órpez, Carlos López-Gómez
Publikováno v:
Journal of Neuroimmunology. 243:1-11
Multiple sclerosis (MS) is a chronic debilitating disease, in which T-cells are considered to play a pivotal role. CD28 is the quintessential costimulatory molecule on T-cells and its expression declines progressively with repeated stimulations, lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a679bf0c324df2ec0e5d7f43c864cc9
https://doi.org/10.1016/j.jneuroim.2011.11.008
https://doi.org/10.1016/j.jneuroim.2011.11.008
Autor:
Oscar Fernandez, Miguel Guerrero, Cristobalina Mayorga, G. Luque, Begoña Oliver-Martos, Margarita Suardíaz, Teresa Órpez, Juan Antonio García-León, R. Maldonado-Sanchez, M.J. Pinto-Medel, Laura Leyva
Publikováno v:
Journal of Neuroimmunology. 230:153-159
IFNß exerts its activity through the interaction with IFNAR, through activation of the JAK/STAT pathway. We analyzed the changes in IFNAR1, IFNAR2, STAT1, STAT2, Tyk2, JAK1, IRF9 and MxA gene expressions after prolonged IFNß treatment, in isolated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1fa1977d73a5b4062d5cf62a403ff6
https://doi.org/10.1016/j.jneuroim.2010.10.033
https://doi.org/10.1016/j.jneuroim.2010.10.033
Autor:
Antonio León, Jose Carlos López-Madrona, Miguel Guerrero, Begoña Oliver, Oscar Fernandez, Victoria Fernández, Marcos Papais Alvarenga, Juan Antonio García-León, Rafael Maldonado-Sanchez, Teresa Órpez, María Jesús Pinto-Medel, G. Luque, Laura Leyva
Publikováno v:
Multiple Sclerosis Journal. 17:368-371
Natalizumab is a monoclonal antibody shown to be highly effective in the treatment of relapsing–remitting multiple sclerosis (RRMS). Patients treated with natalizumab can develop antibodies directed against this agent that may affect the efficacy a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72ea2fa86dfcfe914fbbfdee7319384f
https://doi.org/10.1177/1352458510385508
https://doi.org/10.1177/1352458510385508
Autor:
María Jesús Pinto-Medel, Jose Luis Rodriguez-Bada, José Pavia, Isaac Hurtado-Guerrero, Begoña Oliver-Martos, Oscar Fernández, Elisa Martín Montañez, Teresa Órpez-Zafra, Laura Leyva
Publikováno v:
Bioanalysis. 7(22)
Aim: The soluble isoform of the IFN-β receptor (sIFNAR2) can bind IFN-β and modulate its activity, although its role in autoimmune diseases remains unknown. Methods: A recombinant human sIFNAR2 protein was cloned, expressed and purified after which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ac7462a91fd7eebb8637bb05a8ac38
https://pubmed.ncbi.nlm.nih.gov/26571364
https://pubmed.ncbi.nlm.nih.gov/26571364
Autor:
Carlos López-Gómez, Oscar Fernandez, Juan Antonio García-León, Teresa Órpez-Zafra, Begoña Oliver-Martos, Virginia Reyes-Garrido, Laura Leyva, Carmen Marín-Bañasco
Publikováno v:
CNS drugs. 28(6)
Both the adaptative and the innate immune systems interplay in multiple sclerosis (MS) pathogeny. Killer-cell immunoglobulin-like receptors (KIRs) are key regulators of the immune response, with activating and inhibitory isoforms.In this study we ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bdc4c8d428dfd3881bf0cf1bf891e7a
https://pubmed.ncbi.nlm.nih.gov/24599774
https://pubmed.ncbi.nlm.nih.gov/24599774
Autor:
Rafael Arroyo, Bhairavi Swaminathan, Elena Urcelay, David Otaegui, Mª Jesus Pinto-Medel, Antonio Alcina, Koen Vandenbroeck, Alfredo Antigüedad, Fuencisla Matesanz, Miguel Lucas, María García-Barcina, María Fedetz, Oscar Fernandez, Eva Tolosa, Angelica Cuapio, Teresa Órpez, Javier Olascoaga, Miguel A. Ortiz, Iraide Alloza, Jorge R. Oksenberg
Publikováno v:
Addi. Archivo Digital para la Docencia y la Investigación
instname
PLoS ONE, Vol 8, Iss 4, p e62376 (2013)
Digital.CSIC. Repositorio Institucional del CSIC
PLoS ONE
instname
PLoS ONE, Vol 8, Iss 4, p e62376 (2013)
Digital.CSIC. Repositorio Institucional del CSIC
PLoS ONE
Art. nº e62376; v. 8; issue 4
CD6 has recently been identified and validated as risk gene for multiple sclerosis (MS), based on the association of a single nucleotide polymorphism (SNP), rs17824933, located in intron 1. CD6 is a cell surface sc
CD6 has recently been identified and validated as risk gene for multiple sclerosis (MS), based on the association of a single nucleotide polymorphism (SNP), rs17824933, located in intron 1. CD6 is a cell surface sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af79595eb41455e4e73999619bb05493
https://hdl.handle.net/10668/1362
https://hdl.handle.net/10668/1362
Autor:
Elena Urcelay, María Jesús Pinto-Medel, Francisca Sánchez-Jiménez, Teresa Órpez-Zafra, Almudena Pino-Angeles, Cristina Guijarro-Castro, Begoña Oliver-Martos, Laura Leyva, Roberto Alvarez-Lafuente, Carlos López-Gómez, Oscar Fernandez, Carlos Arnaiz, Jezabel Varadé, Jesús Ortega-Pinazo
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62540 (2013)
PLoS ONE
PLoS ONE
Journal Article; Research Support, Non-U.S. Gov't; TRAIL and TRAIL Receptor genes have been implicated in Multiple Sclerosis pathology as well as in the response to IFN beta therapy. The objective of our study was to evaluate the association of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ec40d2df773361e34d8dff698072f9e
http://europepmc.org/articles/PMC3639207?pdf=render
http://europepmc.org/articles/PMC3639207?pdf=render
Autor:
Bhairavi Swaminathan, Angélica Cuapio, Iraide Alloza, Fuencisla Matesanz, Antonio Alcina, Maria García-Barcina, Maria Fedetz, Oscar Fernández, Miguel Lucas, Teresa Orpez, M Jesus Pinto-Medel, David Otaegui, Javier Olascoaga, Elena Urcelay, Miguel A Ortiz, Rafael Arroyo, Jorge R Oksenberg, Alfredo Antigüedad, Eva Tolosa, Koen Vandenbroeck
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62376 (2013)
CD6 has recently been identified and validated as risk gene for multiple sclerosis (MS), based on the association of a single nucleotide polymorphism (SNP), rs17824933, located in intron 1. CD6 is a cell surface scavenger receptor involved in T-cell
Externí odkaz:
https://doaj.org/article/65611cb5c160440aa96d20cace2f1ddb