Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Teresa, Sementa"'
Autor:
Cornelia Carey, Nisha Singh, Joel T. Dunn, Teresa Sementa, Maria Andreina Mendez, Hester Velthuis, Andreia C. Pereira, Charlotte Marie Pretzsch, Jamie Horder, Stefan Hader, David J. Lythgoe, Diana-Georgina Rotaru, Anthony Gee, Diana Cash, Mattia Veronese, Declan Murphy, Grainne McAlonan
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract The metabotropic glutamate receptor 5 (mGluR5) is a key regulator of excitatory (E) glutamate and inhibitory (I) γ-amino butyric acid (GABA) signalling in the brain. Despite the close functional ties between mGluR5 and E/I signalling, no-on
Externí odkaz:
https://doaj.org/article/02d837ef71704930abb2ee1c81fd3c63
Autor:
Katherine Beck, Atheeshaan Arumuham, Mattia Veronese, Barbara Santangelo, Colm J. McGinnity, Joel Dunn, Robert A. McCutcheon, Stephen J. Kaar, Nisha Singh, Toby Pillinger, Faith Borgan, James Stone, Sameer Jauhar, Teresa Sementa, Federico Turkheimer, Alexander Hammers, Oliver D. Howes
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract N-methyl-D-aspartate receptor (NMDAR) hypofunction is hypothesised to underlie psychosis but this has not been tested early in illness. To address this, we studied 40 volunteers (21 patients with first-episode psychosis and 19 matched health
Externí odkaz:
https://doaj.org/article/01e5daca97374a1c9b30a252f899148c
Autor:
Katherine, Beck, Atheeshaan, Arumuham, Stefan, Brugger, Robert A, McCutcheon, Mattia, Veronese, Barbara, Santangelo, Colm J, McGinnity, Joel, Dunn, Stephen, Kaar, Nisha, Singh, Toby, Pillinger, Faith, Borgan, Teresa, Sementa, Radhouene, Neji, Sameer, Jauhar, Franklin, Aigbirhio, Istvan, Boros, Federico, Turkheimer, Alexander, Hammers, David, Lythgoe, James, Stone, Oliver D, Howes
Publikováno v:
Journal of psychopharmacology (Oxford, England). 36(9)
Evidence from post-mortem studies and in vivo imaging studies suggests there may be reducedIn this study, we investigated the relationship between hippocampal NMDAR and striatal glutamate using simultaneous positron emission tomography-magnetic reson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::48df1a3ea17510e41083f0a78fa78171
https://pubmed.ncbi.nlm.nih.gov/36120998
https://pubmed.ncbi.nlm.nih.gov/36120998
Autor:
Katherine Beck, Atheeshaan Arumuham, Stefan Brugger, Robert A McCutcheon, Mattia Veronese, Barbara Santangelo, Colm J McGinnity, Joel Dunn, Stephen Kaar, Nisha Singh, Toby Pillinger, Faith Borgan, Teresa Sementa, Radhouene Neji, Sameer Jauhar, Franklin Aigbirhio, Istvan Boros, Federico Turkheimer, Alexander Hammers, David Lythgoe, James Stone, Oliver D Howes
Publikováno v:
Beck, K, Arumuham, A, Brugger, S, McCutcheon, R A, Veronese, M, Santangelo, B, McGinnity, C J, Dunn, J, Kaar, S, Singh, N, Pillinger, T, Borgan, F, Sementa, T, Neji, R, Jauhar, S, Aigbirhio, F, Boros, I, Turkheimer, F, Hammers, A, Lythgoe, D, Stone, J & Howes, O D 2022, ' The association between N-methyl-d-aspartate receptor availability and glutamate levels : A multi-modal PET-MR brain imaging study in first-episode psychosis and healthy controls ', Journal of psychopharmacology (Oxford, England), vol. 36, no. 9, pp. 1051-1060 . https://doi.org/10.1177/02698811221099643
Background: Evidence from post-mortem studies and in vivo imaging studies suggests there may be reduced N-methyl-d-aspartate receptor (NMDAR) levels in the hippocampus in patients with schizophrenia. Other studies have reported increased glutamate in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6447a0ee7a2d68ead15c25c3f70e79e7
https://kclpure.kcl.ac.uk/ws/files/184987017/The_association_between_BECK_Publishedonline19September2022_GREEN_AAM.pdf
https://kclpure.kcl.ac.uk/ws/files/184987017/The_association_between_BECK_Publishedonline19September2022_GREEN_AAM.pdf
Autor:
Kavitha Sunassee, Teresa Sementa, Philip J. Blower, Joel Dunn, Jayanta Bordoloi, Antony D. Gee, Salvatore Bongarzone
Publikováno v:
Journal of Medicinal Chemistry
The water-soluble vitamin biotin is essential for cellular growth, development, and well-being, but its absorption, distribution, metabolism, and excretion are poorly understood. This paper describes the radiolabeling of biotin with the positron emis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa3b3c9754b206fe3782e01498fc8cb
http://europepmc.org/articles/PMC7445742
http://europepmc.org/articles/PMC7445742
Autor:
Cornelia Carey, Nisha Singh, Joel T. Dunn, Teresa Sementa, Maria Andreina Mendez, Hester Velthuis, Andreia C. Pereira, Charlotte Marie Pretzsch, Jamie Horder, Stefan Hader, David J. Lythgoe, Diana-Georgina Rotaru, Anthony Gee, Diana Cash, Mattia Veronese, Declan Murphy, Grainne McAlonan
Publikováno v:
Translational psychiatry. 12(1)
The metabotropic glutamate receptor 5 (mGluR5) is a key regulator of excitatory (E) glutamate and inhibitory (I) γ-amino butyric acid (GABA) signalling in the brain. Despite the close functional ties between mGluR5 and E/I signalling, no-one has dir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb2e826a9fef160b94ec65d8e87d61f
https://pubmed.ncbi.nlm.nih.gov/36127322
https://pubmed.ncbi.nlm.nih.gov/36127322
Autor:
Stefan Hader, Federico Turkheimer, Jayanta Bordoloi, Filipa Mota, Teresa Sementa, Mattia Veronese, Nisha Singh, Diana Cash, Carlotta Taddei, Thomas R. Eykyn, Natasha Moses
Publikováno v:
Mota, F, Sementa, T, Taddei, C, Moses, N, Bordoloi, J, Hader, S, Eykyn, T, Cash, D, Turkheimer, F E, Veronese, M & Singh, N 2020, ' Investigating the effects of ebselen, a potential new lithium mimetic, on glutamate transmission ', Synapse (New York, N.Y.), vol. 74, no. 7, e22151, pp. e22151 . https://doi.org/10.1002/syn.22151
Ebselen was originally developed as a glutathione peroxidase mimic in the treatment of stroke (Parnham & Sies, 2013), and recently explored as a safer alternative to lithium in the treatment of bipolar disorder (Singh et al., 2013). Coincidentally, u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afcac744c1d1340a314a8f494b25584c
http://hdl.handle.net/11577/3411892
http://hdl.handle.net/11577/3411892
Autor:
Teresa Sementa, Alessandra Ferocino, Phil Blower, Kavitha Sunassee, Antony D. Gee, Salvatore Bongarzone, Jayanta Bordoloi, Joel Dunn, Elisabetta Barbon, Jana Kim
Publikováno v:
Nuclear Medicine and Biology. :S56-S57
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::196c2baf7b59673d7ff6d8ce1076e68a
https://doi.org/10.1016/s0969-8051(21)00357-7
https://doi.org/10.1016/s0969-8051(21)00357-7
Autor:
Teresa Sementa, Caleb Gakpetor, Nisha Singh, Filippo Basagni, Salvatore Bongarzone, Vincent Faugeras, Antony D. Gee, Jayanta Bordoloi
Publikováno v:
Bongarzone, S, Basagni, F, Sementa, T, Singh, N, Gakpetor, C, Faugeras, V, Bordoloi, J & Gee, A D 2018, ' Development of [ 18 F]FAMTO: A novel fluorine-18 labelled positron emission tomography (PET) radiotracer for imaging CYP11B1 and CYP11B2 enzymes in adrenal glands ', Nuclear Medicine and Biology, vol. 68-69, pp. 14-21 . https://doi.org/10.1016/j.nucmedbio.2018.11.002
IntroductionPrimary aldosteronism accounts for 6–15% of hypertension cases, the single biggest contributor to global morbidity and mortality. Whilst ~50% of these patients have unilateral aldosterone-producing adenomas, only a minority of these hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::947cb9fdf416d966e81a4e3a0310dd17
https://kclpure.kcl.ac.uk/en/publications/a643b2ad-5267-4869-9fc1-0ade384c7067
https://kclpure.kcl.ac.uk/en/publications/a643b2ad-5267-4869-9fc1-0ade384c7067
Autor:
Jamie Horder, Anne Lingford-Hughes, Jacqueline Borg, Max Andersson, Ämma Tangen, Christer Halldin, Karen Higgins, David J. Nutt, Inge Mick, Federico Turkheimer, Lars Farde, Sudhakar Selvaraj, Oliver D. Howes, Debbie Spain, Sven Bölte, Teresa Sementa, Maria Andreina Mendez, Declan G. Murphy, Nisha Singh, Diana Cash, Antony D. Gee, Johan Lundberg, Mattia Veronese
Publikováno v:
Horder, J, Andersson, M, Mendez Hernandez, M A, Singh, N, Tangen, A, Lundberg, J, Gee, A, Halldin, C, Veronese, M, Bolte, S, Farde, L, Sementa, T, Cash, D, K, H, Spain, D, Turkheimer, F, Mick, I, Selvaraj, S, Nutt, DJ, Lingford-Hughes, A, Howes, O, Murphy, D G & Borg, J 2018, ' GABA A receptor availability is not altered In adults with autism spectrum disorder or in mouse models ', Science Translational Medicine, vol. 10, no. 461, eaam8434 . https://doi.org/10.1126/scitranslmed.aam8434
Science Translational Medicine
Science Translational Medicine
Preliminary studies have suggested that γ-aminobutyric acid type A (GABAA) receptors, and potentially the GABAA α5 subtype, are deficient in autism spectrum disorder (ASD). However, prior studies have been confounded by the effects of medications,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e821826ce59b82c3ab636d2b0e125ede
https://kclpure.kcl.ac.uk/ws/files/87620423/GABAA_Receptor_Availability_Is_HORDER_Accepted10November2017_GREEN_AAM.pdf
https://kclpure.kcl.ac.uk/ws/files/87620423/GABAA_Receptor_Availability_Is_HORDER_Accepted10November2017_GREEN_AAM.pdf