Zobrazeno 1 - 10
of 261
pro vyhledávání: '"Teresa, Amaral"'
Autor:
Lisa Wiens, Gerd Grözinger, Helmut Dittmann, Karolin Thiel, Ulrike Leiter, Teresa Amaral, Lena Nanz, Lukas Flatz, Andrea Forschner
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 16 (2024)
Background: Uveal melanoma is the most common malignant tumor of the eye in adults. About half of the patients develop distant metastases, most commonly liver metastases (>90%). These are associated with poorer overall survival compared to patients w
Externí odkaz:
https://doaj.org/article/b78e3bcdd36e47719be5e1d9b1f76552
Autor:
Francisco Meraz-Torres, Heike Niessner, Sarah Plöger, Simon Riel, Barbara Schörg, Nicolas Casadei, Manfred Kneilling, Martin Schaller, Lukas Flatz, Boris Macek, Thomas Eigentler, Olaf Rieß, Claus Garbe, Teresa Amaral, Tobias Sinnberg
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-22 (2024)
Abstract Background MEK inhibitors (MEKi) were shown to be clinically insufficiently effective in patients suffering from BRAF wild-type (BRAF WT) melanoma, even if the MAPK pathway was constitutively activated due to mutations in NRAS or NF-1. Thus,
Externí odkaz:
https://doaj.org/article/35307e889f494a0d91d148dbfa645149
Autor:
Ana Fortuna, Teresa Amaral
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Acral and mucosal melanoma are uncommon variants of melanoma. Acral melanoma has an age-adjusted incidence of approximately 1.8 cases per million individuals per year, accounting for about 2% to 3% of all melanoma cases. On the other hand, mucosal me
Externí odkaz:
https://doaj.org/article/72135d3520494fbe9dd26db61191f537
Autor:
Felix Peisen, Annika Gerken, Isabel Dahm, Konstantin Nikolaou, Thomas Eigentler, Teresa Amaral, Jan H Moltz, Ahmed E Othman, Sergios Gatidis
Publikováno v:
PLoS ONE, Vol 19, Iss 1, p e0296253 (2024)
BackgroundCheckpoint inhibitors have drastically improved the therapy of patients with advanced melanoma. 18F-FDG-PET/CT parameters might act as biomarkers for response and survival and thus can identify patients that do not benefit from immunotherap
Externí odkaz:
https://doaj.org/article/369e640cc914415b974b713807a5a996
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionCombined immune checkpoint inhibition (ICI) with ipilimumab and nivolumab is a widely used treatment regimen for metastatic melanoma with non-resectable metastases. Nevertheless, the standard dose of ipilimumab 3 mg/kg bw and nivolumab 1
Externí odkaz:
https://doaj.org/article/ceb67aa294dc4f9797190022c91f9626
Autor:
Daniel Delgado-Bellido, Esteban Zamudio-Martínez, Mónica Fernández-Cortés, Ana Belén Herrera-Campos, Joaquin Olmedo-Pelayo, Carmen Jordán Perez, José Expósito, Enrique de Álava, Ana Teresa Amaral, Francisco O’ Valle, Angel Garcia Diaz, F. J. Oliver
Publikováno v:
Cell Death and Disease, Vol 14, Iss 2, Pp 1-11 (2023)
Abstract Vasculogenic Mimicry (VM) refers to the capacity to form a blood network from aggressive cancer cells in an independent way of endothelial cells, to provide nutrients and oxygen leading to enhanced microenvironment complexity and treatment f
Externí odkaz:
https://doaj.org/article/4b08f40ad789471d99691db03f23e4ae
Autor:
Eftychia Chatziioannou, Jana Roßner, Thazin New Aung, David L. Rimm, Heike Niessner, Ulrike Keim, Lina Maria Serna-Higuita, Irina Bonzheim, Luis Kuhn Cuellar, Dana Westphal, Julian Steininger, Friedegund Meier, Oltin Tiberiu Pop, Stephan Forchhammer, Lukas Flatz, Thomas Eigentler, Claus Garbe, Martin Röcken, Teresa Amaral, Tobias Sinnberg
Publikováno v:
EBioMedicine, Vol 93, Iss , Pp 104644- (2023)
Summary: Background: Recent advances in digital pathology have enabled accurate and standardised enumeration of tumour-infiltrating lymphocytes (TILs). Here, we aim to evaluate TILs as a percentage electronic TIL score (eTILs) and investigate its pro
Externí odkaz:
https://doaj.org/article/35c191c0b266487cb0126f25360675a8
Autor:
Teresa Amaral, Benjamin Weide, Graham Pawelec, Thomas Eigentler, Claus Garbe, Patrick Terheyden, Friedegund Meier, Kilian Wistuba-Hamprecht, Alexander Martens, Jonas Bochem, Janine Spreuer, Andrea Gaissler, Shannon Ottmann, Nikolaus Benjamin Wagner, Manfred Claassen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 6 (2023)
Background The need for reliable clinical biomarkers to predict which patients with melanoma will benefit from immune checkpoint blockade (ICB) remains unmet. Several different parameters have been considered in the past, including routine differenti
Externí odkaz:
https://doaj.org/article/521aee0a376b4390b6c381956eae52b4
Autor:
Felix Peisen, Annika Gerken, Alessa Hering, Isabel Dahm, Konstantin Nikolaou, Sergios Gatidis, Thomas K. Eigentler, Teresa Amaral, Jan H. Moltz, Ahmed E. Othman
Publikováno v:
Diagnostics, Vol 13, Iss 20, p 3210 (2023)
Background: The aim of this study was to investigate whether the combination of radiomics and clinical parameters in a machine-learning model offers additive information compared with the use of only clinical parameters in predicting the best respons
Externí odkaz:
https://doaj.org/article/7840e25145804ec082bc1c9471140dbc
Autor:
Ulrike Leiter, Markus V. Heppt, Theresa Steeb, Mareike Alter, Teresa Amaral, Andrea Bauer, Falk G. Bechara, Jürgen C. Becker, Eckhard W. Breitbart, Helmut Breuninger, Thomas Diepgen, Thomas Dirschka, Thomas Eigentler, A.K. Stephan El Gammal, Moritz Felcht, Michael J. Flaig, Markus Follmann, Klaus Fritz, Stephan Grabbe, Rüdiger Greinert, Ralf Gutzmer, Axel Hauschild, Uwe Hillen, Stephan Ihrler, Swen Malte John, Lukas Kofler, Oliver Koelbl, Albrecht Krause-Bergmann, Klaus Kraywinkel, Steffen Krohn, Thomas Langer, Carmen Loquai, Christoph R. Löser, Peter Mohr, Dorothée Nashan, Monika Nothacker, Christina Pfannenberg, Carmen Salavastru, Lutz Schmitz, Eggert Stockfleth, Rolf-Markus Szeimies, Claas Ulrich, Susanne Voelter-Mahlknecht, Dirk Vordermark, Michael Weichenthal, Julia Welzel, Kai Wermker, Susanne Wiegand, Claus Garbe, Carola Berking
Publikováno v:
EJC Skin Cancer, Vol 1, Iss , Pp 100004- (2023)
Actinic keratosis (AK) are common lesions in light-skinned individuals that can potentially progress to cutaneous squamous cell carcinoma (cSCC). Both conditions may be associated with significant morbidity and constitute a major disease burden, espe
Externí odkaz:
https://doaj.org/article/85150b273461404ea9bcf7212bcf4400