Výsledky vyhledávání - "Terence W Spithill"

Akademický článek

A portrait of the transcriptome of the neglected trematode, Fasciola gigantica--biological and biotechnological implications.

Autor: Neil D Young, Aaron R Jex, Cinzia Cantacessi, Ross S Hall, Bronwyn E Campbell, Terence W Spithill, Sirikachorn Tangkawattana, Prasarn Tangkawattana, Thewarach Laha, Robin B Gasser

Publikováno v: PLoS Neglected Tropical Diseases, Vol 5, Iss 2, p e1004 (2011)

Fasciola gigantica (Digenea) is an important foodborne trematode that causes liver fluke disease (fascioliasis) in mammals, including ungulates and humans, mainly in tropical climatic zones of the world. Despite its socioeconomic impact, almost nothi

Externí odkaz: https://doaj.org/article/0b59ceafc071451c80aa75fa4518ffb1

Zobrazit plný text záznamu

Use of multiplexed tandem PCR to estimate the prevalence and intensity of Theileria orientalis infections in cattle

Autor: Piyumali K. Perera, Terence W. Spithill, Abdul Jabbar, Hanh T.H. Nguyen, Allan C. Y. Cheng, Grant Rawlin, Aaron R. Jex, J. Malmo, Elizabeth Read, Simon Nyein, Robin B. Gasser

Publikováno v: Infection, Genetics and Evolution. 32:68-73

This study employed a semi-quantitative, multiplexed tandem PCR (MT-PCR) to assess the prevalence and infection intensity of four genotypes (buffeli, chitose, ikeda and type 5) of Theileria orientalis in cattle in Australia. Genomic DNA samples from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4475de110c728477e6036e275a845028
https://doi.org/10.1016/j.meegid.2015.02.021

Zobrazit plný text záznamu

Analysis of Fasciola cathepsin L5 by S2 subsite substitutions and determination of the P1–P4 specificity reveals an unusual preference

Autor: Youngchool Choe, Luke J. Norbury, Terence W. Spithill, Andrew Hung, Robert N. Pike, Charles S. Craik, Simone A. Beckham, Peter M. Smooker, John V. Fecondo

Publikováno v: Biochimie. 94:1119-1127

Fasciola parasites (liver flukes) express numerous cathepsin L proteases that are believed to be involved in important functions related to host invasion and parasite survival. These proteases are evolutionarily divided into clades that are proposed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76139b401280461070c01251b6c56bc7
https://doi.org/10.1016/j.biochi.2012.01.011

Zobrazit plný text záznamu

A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites

Autor: Terence W Spithill, Peter M. Smooker, Deanne L.V. Greenwood, Ruby H. P. Law, Carolyn I Phillips, Robert N. Pike, Nirma Samarawickrema, Lakshmi C. Wijeyewickrema, Boris Turk, David Piedrafita, Noelene Sheila Quinsey, Theresa H.T. Coetzer, James A. Irving, Matthew Bogyo, Steven H. L. Verhelst, Simone A. Beckham

Publikováno v: The International Journal of Biochemistry & Cell Biology. 41:1601-1612

The newly excysted juvenile (NEJ) stage of the Fasciola hepatica lifecycle occurs just prior to invasion into the wall of the gut of the host, rendering it an important target for drug development. The cathepsin B enzymes from NEJ flukes have recentl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c35df2910ab0b877d8d0a293a66d92
https://doi.org/10.1016/j.biocel.2009.02.003

Zobrazit plný text záznamu

Peritoneal Lavage Cells of Indonesian Thin-Tail Sheep Mediate Antibody-Dependent Superoxide Radical Cytotoxicity In Vitro against Newly Excysted Juvenile Fasciola gigantica but Not Juvenile Fasciola hepatica

Autor: David Piedrafita, Jill Louise Pleasance, Elza Nicole Theresia Meeusen, Herman W. Raadsma, E. Estuningsih, Rhoda Prowse, Terence W Spithill

Publikováno v: Infection and Immunity. 75:1954-1963

Indonesian thin-tail (ITT) sheep resist infection by Fasciola gigantica by an immunological mechanism within 2 to 4 weeks of infection yet are susceptible to F. hepatica infection. Studies of ITT sheep show that little liver damage occurs following F

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac85d46153202f8c0524eef2f806d8f3
https://doi.org/10.1128/iai.01034-06

Zobrazit plný text záznamu

Identification of two allelic forms of ovine CD4 exhibiting a Ser183/Pro183 polymorphism in the coding sequence of domain 3

Autor: R Boscariol, David Piedrafita, Herman W. Raadsma, Jill Louise Pleasance, Terence W Spithill

Publikováno v: Veterinary Immunology and Immunopathology. 113:305-312

The ovine CD4 cDNA sequence from four sheep sources (Australian Merino, Indonesian Thin Tail, Canadian cross bred, Prealpes du sud) predicts a protein of 455 residues with position 130 in the V2 domain exhibiting a W instead of C suggesting that, lik

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30067626d76f0fae979ac3837f7e038f
https://doi.org/10.1016/j.vetimm.2006.05.015

Zobrazit plný text záznamu

Production and processing of a recombinant Fasciola hepatica cathepsin B-like enzyme (FhcatB1) reveals potential processing mechanisms in the parasite

Autor: Noelene Sheila Quinsey, Ruby H-P Law, Simone A. Beckham, Robert N. Pike, James H. McKerrow, Conor R. Caffrey, Terence W Spithill, Peter M. Smooker

Publikováno v: Biological Chemistry. 387:1053-1061

The liver fluke,Fasciola hepatica, apparently uses a number of cysteine proteases during its life cycle, most likely for feeding, immune evasion and invasion of tissues. A cathepsin B-like enzyme (herein referred to as FhcatB1) appears to be a major

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea1c07520089990c6d55d76153e27f2
https://doi.org/10.1515/bc.2006.130

Zobrazit plný text záznamu

Induction of Strain-Transcending Immunity against Plasmodium chabaudi adami Malaria with a Multiepitope DNA Vaccine

Autor: K. Grubb, David Proll, Tatiana Scorza, Adam Rainczuk, Terence W Spithill, Peter M. Smooker

Publikováno v: Infection and Immunity. 73:2974-2985

A major goal of current malaria vaccine programs is to develop multivalent vaccines that will protect humans against the many heterologous malaria strains that circulate in endemic areas. We describe a multiepitope DNA vaccine, derived from a genomic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9540a404c06f7ddd52bae701fcd1b121
https://doi.org/10.1128/iai.73.5.2974-2985.2005

Zobrazit plný text záznamu

Immunology of the host–parasite relationship in fasciolosis (Fasciola hepaticaandFasciola gigantica)

Autor: Herman W. Raadsma, Terence W Spithill, Rhoda Prowse, David Piedrafita

Publikováno v: Canadian Journal of Zoology. 82:233-250

The protective resolution of liver fluke (Fasciola hepatica and Fasciola gigantica) infection is a dynamic interplay between the host's effector responses and the parasite's defence and immunomodulatory systems. The evidence suggests that the juvenil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::271fb3ed66184bcb0d6c31b2114457fb
https://doi.org/10.1139/z03-216

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání