Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Terence R. Jones"'
Autor:
Erin C. Barron, Terence R. Jones, William R. Freeman, Ajay M. Tammewar, Bruce Babson, Lingyun Cheng, I. Falkenstein, Igor Kozak
Publikováno v:
Current Eye Research. 35:742-750
To evaluate the intraocular properties of A36, a peptide that directly antagonizes the cell surface urokinase receptor and so prevents pericellular urokinase plasminogen activator activity.A total of 41 rabbits were used. The toxicity study tested th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74bfdf643328b3933e3a0809e6c7d760
https://doi.org/10.3109/02713683.2010.486519
https://doi.org/10.3109/02713683.2010.486519
Autor:
Stanley P. Azen, Christina J Flaxel, Laurie LaBree, Hyoung Jun Koh, William R. Freeman, M. Wills, Terence R. Jones, Linguen Cheng
Publikováno v:
Retina. 26:202-209
Purpose: To evaluate the inhibitory effects of a urokinase-derived octapeptide, A˚6, on laser-induced choroidal neovascularization (CNV) in monkeys. Methods: Twenty female cynomolgus monkeys were randomly grouped into weekly or monthly A˚6 treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6360fe40a731ca40853bcfb9ff1f9913
https://doi.org/10.1097/00006982-200602000-00014
https://doi.org/10.1097/00006982-200602000-00014
Autor:
Hyoung Jun Koh, William R. Freeman, Marie C. Davidson, Kenichiro Bessho, Lingyun Cheng, Terence R. Jones
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 20:439-449
To investigate the intraocular properties of an antiangiogenic peptide, A6, a total of 70 New Zealand rabbit eyes were used. For the toxicity study, 0.05 mL of 0.459 M or 0.148 M A6 was injected intravitreally; right eyes received A6, and left eyes r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b1792edf3d718e78f45793aab5cdbb6
https://doi.org/10.1089/jop.2004.20.439
https://doi.org/10.1089/jop.2004.20.439
Publikováno v:
The American Journal of Pathology. 162:619-626
The high rate of prostate cancer mortality invariably reflects the inability to control the spread of the disease. The urokinase-type plasminogen activator and its receptor (u-PAR) contribute to prostate cancer metastases by promoting extracellular m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac0277fe21f4ecef4d5e7fdb762b7fe
https://doi.org/10.1016/s0002-9440(10)63855-2
https://doi.org/10.1016/s0002-9440(10)63855-2
Autor:
Andrew P. Mazar, Webster K. Cavenee, Kazuhiko Mishima, Marilyn Skelly, Xu Dong Wang, Terence R. Jones, Allen M. Gown, H.-J. Su Huang, Xiang-Dong Ji
Publikováno v:
Proceedings of the National Academy of Sciences. 97:8484-8489
The urokinase plasminogen activator system is involved in angiogenesis and tumor growth of malignant gliomas, which are highly neovascularized and so may be amenable to antiangiogenic therapy. In this paper, we describe the activity of Å6, an octam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ae48d7015a08b7374f065ddaef023b
https://doi.org/10.1073/pnas.150239497
https://doi.org/10.1073/pnas.150239497
Autor:
Yongjing Guo, Abd Al‐Roof Higazi, Ani Arakelian, Bruce S. Sachais, Douglas Cines, Ronald H. Goldfarb, Terence R. Jones, H. Kwaan, Andrew P. Mazar, Shafaat A. Rabbani
Publikováno v:
The FASEB Journal. 14:1400-1410
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72e2ee80da95a0c8aab75f5dc0f3d514
https://doi.org/10.1096/fasebj.14.10.1400
https://doi.org/10.1096/fasebj.14.10.1400
Autor:
Ronald H. Goldfarb, Douglas B. Cines, Andrew P. Mazar, Abd Al-Roof Higazi, Ani Arakelian, Shafaat A. Rabbani, Hau C. Kwaan, Terence R. Jones, Yongjing Guo, Bruce S. Sachais
Publikováno v:
The FASEB Journal. 14:1400-1410
Urokinase plasminogen activator (uPA) plays an important role in the progression of several malignancies including breast cancer. We have identified a noncompetitive antagonist of the uPA-uPAR interaction derived from a nonreceptor binding region of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90731b4687d01056003e80235283ba86
https://doi.org/10.1096/fj.14.10.1400
https://doi.org/10.1096/fj.14.10.1400
Autor:
Andrea Crabtree, Heike Allgayer, Gary E. Gallick, Heng Wang, Douglas D. Boyd, Andrew P. Mazar, Terence R. Jones, Alan J. Kraker
Publikováno v:
Journal of Biological Chemistry. 274:18428-18437
Since c-src overexpression increases colonic cell invasiveness and because both Src activity and urokinase receptor protein are elevated in invasive colon cancers, the present study was undertaken: 1) to determine if a constitutively active Src regul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ede5c36b099e854d3984f0bdfc236fda
https://doi.org/10.1074/jbc.274.26.18428
https://doi.org/10.1074/jbc.274.26.18428
Autor:
Nils Brünner, Michael H. Silverman, Luceli C. Cuasay, Joan Kroener, Ursula A. Matulonis, Gil N. Lam, Anna Berkenblit, Bruce J. Dezube, Michael A. Gold, Terence R. Jones
Publikováno v:
Gynecologic oncology. 99(1)
Objectives. The aim of this study was to define the toxicity, maximum feasible dose (MFD), and pharmacokinetics (PK) of A6, a peptide derived from human urokinase plasminogen activator (uPA), in patients with advanced gynecologic cancers, and to expl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8db368c89f83239f045cec542ae6d1bb
https://pubmed.ncbi.nlm.nih.gov/16023182
https://pubmed.ncbi.nlm.nih.gov/16023182
Publikováno v:
Archives of ophthalmology (Chicago, Ill. : 1960). 122(12)
Objectives To determine the role played by the urokinase plasminogen activator(uPA) and urokinase plasminogen activator receptor (uPAR) system in choroidalneovascularization (CNV) and whether inhibition of this system can suppressthe extent of CNV in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29eb90a87feb9f6404dbc9623427d130
https://pubmed.ncbi.nlm.nih.gov/15596589
https://pubmed.ncbi.nlm.nih.gov/15596589