Výsledky vyhledávání - "Terence K Smith"

Akademický článek

Serum response factor regulates smooth muscle contractility via myotonic dystrophy protein kinases and L-type calcium channels.

Autor: Moon Young Lee, Chanjae Park, Se Eun Ha, Paul J Park, Robyn M Berent, Brian G Jorgensen, Robert D Corrigan, Nathan Grainger, Peter J Blair, Orazio J Slivano, Joseph M Miano, Sean M Ward, Terence K Smith, Kenton M Sanders, Seungil Ro

Publikováno v: PLoS ONE, Vol 12, Iss 2, p e0171262 (2017)

Serum response factor (SRF) transcriptionally regulates expression of contractile genes in smooth muscle cells (SMC). Lack or decrease of SRF is directly linked to a phenotypic change of SMC, leading to hypomotility of smooth muscle in the gastrointe

Externí odkaz: https://doaj.org/article/e61d17fcddeb42c798c6f15cef0042fa

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Akademický článek

Use of genetically encoded calcium indicators (GECIs) combined with advanced motion tracking techniques to examine the behavior of neurons and glia in the enteric nervous system of the intact murine colon

Autor: Grant Willem Hennig, Thomas W Gould, Sang D Koh, Robert D Corrigan, Dante J Heredia, Matthew C Shonnard, Terence K Smith

Publikováno v: Frontiers in Cellular Neuroscience, Vol 9 (2015)

Genetically encoded Ca2+ indicators (GECIs) have been used extensively in many body systems to detect Ca2+ transients associated with neuronal activity. Their adoption in enteric neurobiology has been slower, although they offer many advantages in te

Externí odkaz: https://doaj.org/article/3abddaec9790449a8d339667d7a89249

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Activity within specific enteric neurochemical subtypes is correlated with distinct patterns of gastrointestinal motility in the murine colon

Autor: William A. Swope, Dante J. Heredia, Thomas W. Gould, Terence K. Smith, Robert D. Corrigan

Publikováno v: Am J Physiol Gastrointest Liver Physiol

The enteric nervous system in the large intestine generates two important patterns relating to motility: 1) propagating rhythmic peristaltic smooth muscle contractions referred to as colonic migrating motor complexes (CMMCs) and 2) tonic inhibition,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba27f5e9a419085320707029c09f18fa
https://doi.org/10.1152/ajpgi.00252.2018

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Pathology of gastroparesis: ICC, enteric neurons and fibrosis

Autor: Terence K. Smith, Mohammad Bashashati

Gastroparesis is a motility disorder of the upper gastrointestinal tract in the setting of delayed stomach emptying. Gastroparesis presents with refractory nausea and vomiting, early satiety, bloating as well as abdominal pain. The pathophysiology of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa97f066fc8951edba1991e0b6fac76d
https://doi.org/10.1016/b978-0-12-818586-5.00008-9

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List of Contributors

Autor: Thomas Abell, Nitin K. Ahuja, M. Showkat Ali, Sreerup Banerjee, Mohammad Bashashati, Laren Becker, Meagan Bridges, Robert Bulat, Michael Camilleri, David J. Cangemi, Florencia Carbone, Lakshmikanth L. Chikkamenahalli, John O. Clarke, Brian R. Davis, Maryangela DeGrazia-DiTucci, Jesus Diaz, Yellowlees Douglas, Mohamed Elmasry, Liz Febo-Rodriguez, Reid Fletcher, Mark Fox, Marvin I. Friedman, Mahesh Gajendran, Prianka Gajula, Zorisadday Gonzalez, Madhusudan Grover, Gulara Hajiyeva, Ciel Harris, William L. Hasler, Carissa Haston, Michael Horowitz, MariaLisa Itzoe, Safwan Jaradeh, Karen L. Jones, Anthony N. Kalloo, Joyce E. King, Kenneth L. Koch, Braden Kuo, Brian E. Lacy, Allen Lee, Linda A. Lee, Ta-ya Lee, Marissa Lombardi, Luca Marciani, Alan H. Maurer, Richard McCallum, Richard W. McCallum, Baha Moshiree, Saowanee Ngamruengphong, Helen Parker, Henry P. Parkman, Eamonn M.M. Quigley, Christopher K. Rayner, Dennis Revicki, Ceciel Rooker, Irene Sarosiek, Ron Schey, Jolien Schol, Robert J. Shulman, Malorie Simons, Dong In Sinn, Samantha Smith, Terence K. Smith, William J. Snape, Estelle T. Spear, Lee L. Swanström, Jan Tack, Aylin Tansel, Glenn J. Treisman, Melissa Adams VanHouten, Christopher David Vélez, John M. Wo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d8ffbabcaf8c8498e9470e15a78dbfe
https://doi.org/10.1016/b978-0-12-818586-5.00048-x

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Colonic Migrating Motor Complexes, High Amplitude Propagating Contractions, Neural Reflexes and the Importance of Neuronal and Mucosal Serotonin

Autor: Terence K. Smith, Kyu Joo Park, Grant W. Hennig

Publikováno v: Journal of Neurogastroenterology and Motility

The colonic migrating motor complex (CMMC) is a critical neurally mediated rhythmic propulsive contraction observed in the large intestine of many mammals. It seems to be equivalent to the high amplitude propagating contractions (HAPCs) in humans. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f0e33b48152d21f86b79b80afd0a85
https://doi.org/10.5056/jnm14092

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CrossTalk proposal: 5-HT is necessary for peristalsis

Autor: Michael D. Gershon, Terence K. Smith

Publikováno v: The Journal of Physiology. 593:3225-3227

The overwhelming preponderance of the 5-HT of every known mammal is in the gut (Erspamer, 1966; Gershon & Tack, 2007; Gershon, 2013). Enteric 5-HT must be an important signalling molecule to be so conserved. Most enteric 5-HT is in enterochromaffin (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c421a3f7e85d4a5bca670a31b2d5cc29
https://doi.org/10.1113/jp270182

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Important role of mucosal serotonin in colonic propulsion and peristaltic reflexes:in vitroanalyses in mice lacking tryptophan hydroxylase 1

Autor: Robert D. Corrigan, Takanubu Okamoto, Terence K. Smith, Michael D. Gershon, Dante J. Heredia, Sang Don Koh

Publikováno v: The Journal of Physiology. 591:5939-5957

Key points • Previous studies have indicated that neither neuronal nor mucosal 5-hydroxytryptamine (5-HT) are important for colonic migrating motor complexes (CMMCs) or faecal pellet propulsion. Therefore, tryptophan hydroxylase 1 knockout (TPH1KO)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4ff3b1bcfea7b07ba095d10a246bcc71
https://doi.org/10.1113/jphysiol.2013.256230

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A model of the enteric neural circuitry underlying the generation of rhythmic motor patterns in the colon: the role of serotonin

Autor: Terence K. Smith, Sang Don Koh

Publikováno v: American journal of physiology. Gastrointestinal and liver physiology. 312(1)

We discuss the role of multiple cell types involved in rhythmic motor patterns in the large intestine that include tonic inhibition of the muscle layers interrupted by rhythmic colonic migrating motor complexes (CMMCs) and secretomotor activity. We p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec8ffa0f8dd32aa735e7f67f11219b1
https://pubmed.ncbi.nlm.nih.gov/27789457

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Analysis of spontaneous and nerve-evoked calcium transients in intact extraocular muscles in vitro

Autor: Robert D. Corrigan, Grant W. Hennig, Christopher S. von Bartheld, Cheng-Yuan Feng, Terence K. Smith

Publikováno v: Experimental Eye Research. 100:73-85

Extraocular muscles (EOMs) have unique calcium handling properties, yet little is known about the dynamics of calcium events underlying ultrafast and tonic contractions in myofibers of intact EOMs. Superior oblique EOMs of juvenile chickens were diss

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c3eee922db13adbe634b72cc2bd3701
https://doi.org/10.1016/j.exer.2012.04.007

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