Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Terence J. Campbell"'
Autor:
Terence J. Campbell
Publikováno v:
Interventional Cardiology and Cardiac Catheterisation ISBN: 9781351060356
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a2d2223b149160c83b2cc5a6e7d55a2
https://doi.org/10.1201/9781351060356-22
https://doi.org/10.1201/9781351060356-22
Publikováno v:
Biophysical Journal. 92(11):3915-3929
The scorpion toxin CnErg1 binds to human ether-a-go-go related gene (hERG) K(+) channels with a 1:1 stoichiometry and high affinity. However, in contrast to other scorpion toxin-ion channel interactions, the inhibition of macroscopic hERG currents by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::962de50080fcb34e04cbfca1e0f6602d
Autor:
Mari Kondo, Rajesh N. Subbiah, Catherine E. Clarke, Adam P. Hill, JingTing Zhao, Jamie I. Vandenberg, Terence J. Campbell
Publikováno v:
The Journal of Physiology. 573:291-304
The ether-a-go-go (EAG) family of voltage-gated K+ channels contains three subfamilies, EAG, ether-a-go-go related (ERG) and ether-a-go-go like (ELK). The human ether-a-go-go related gene (hERG) K+ channel has been of significant interest because los
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::831b3c064a6a8f46417d9daa49b8a3cf
https://doi.org/10.1113/jphysiol.2006.108332
https://doi.org/10.1113/jphysiol.2006.108332
Publikováno v:
The Journal of Physiology. 569:367-379
Inherited mutations or drug-induced block of voltage-gated ion channels, including the human ether-a-go-go-related gene (HERG) K+ channel, are significant causes of malignant arrhythmias and sudden death. The fourth transmembrane domain (S4) of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7498d8f4e85b6896fa457b88e4062682
https://doi.org/10.1113/jphysiol.2005.097386
https://doi.org/10.1113/jphysiol.2005.097386
Publikováno v:
Clinical and Experimental Pharmacology and Physiology. 31:906-912
SUMMARY 1. In recent years, the identification of the gene defects in a vast array of monogenic disorders has revolutionized our understanding of the basic mechanisms underlying numerous disease processes. 2. Mutations in cardiac ion channels have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b0e760cc4900b4f8b8b995246fc3770
https://doi.org/10.1111/j.1440-1681.2004.04132.x
https://doi.org/10.1111/j.1440-1681.2004.04132.x
Autor:
Jamie I. Vandenberg, JingTing Zhao, Catherine E. Clarke, Rajesh N. Subbiah, David Smith, Terence J. Campbell
Publikováno v:
The Journal of Physiology. 558:417-431
The human ether-a-go-go related gene (HERG) encodes the pore forming α-subunit of the rapid delayed rectifier K+ channel which is central to the repolarization phase of the cardiac action potential. HERG K+ channels have unusual kinetics characteriz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c89c4a013adfe46a862e34d601d6141
https://doi.org/10.1113/jphysiol.2004.062588
https://doi.org/10.1113/jphysiol.2004.062588
Autor:
Louise J. Brown, Greg J. Pankhurst, W. Douglas Fairlie, Paul M. G. Curmi, Asne R. Bauskin, Dene R. Littler, S. Pankhurst, Raffaella Tonini, Stephen J. Harrop, Matthew Z. DeMaere, Michele Mazzanti, Terence J. Campbell, Samuel N. Breit
Publikováno v:
Journal of Biological Chemistry. 279:9298-9305
Most proteins adopt a well defined three-dimensional structure; however, it is increasingly recognized that some proteins can exist with at least two stable conformations. Recently, a class of intracellular chloride ion channel proteins (CLICs) has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f106439cfb382c3d95f76192e2a8e972
https://doi.org/10.1074/jbc.m308444200
https://doi.org/10.1074/jbc.m308444200
Autor:
Jane A. Bursill, Philip W. Kuchel, Paramjit S. Bansal, Catherine E. Clarke, Jamie I. Vandenberg, Samuel N. Breit, Margaret Sunde, Allan M. Torres, Asne R. Bauskin, Terence J. Campbell, Paul F. Alewood, David Smith
Publikováno v:
Journal of Biological Chemistry. 278:42136-42148
The HERG K+ channel has very unusual kinetic behavior that includes slow activation but rapid inactivation. These features are critical for normal cardiac repolarization as well as in preventing lethal ventricular arrhythmias. Mutagenesis studies hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74e69f4274a9d6e84f305414794fa24c
https://doi.org/10.1074/jbc.m212824200
https://doi.org/10.1074/jbc.m212824200
Autor:
Stefan A. Mann, Jamie I. Vandenberg, Juliane Heide, Mark Perrin, Adam P. Hill, Terence J. Campbell
Publikováno v:
Molecular pharmacology. 85(5)
The Kv11.1 potassium channel is the molecular target for the majority of drugs implicated in acquired long QT syndrome, the most common cause of drug-induced sudden cardiac death, and a common reason for drug restriction or withdrawal from the market
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0af064ca75a6cb6cccd46904b7b5ad8
https://pubmed.ncbi.nlm.nih.gov/24586056
https://pubmed.ncbi.nlm.nih.gov/24586056
Autor:
Stella M. Valenzuela, T. Reztsova, Matthew Z. DeMaere, Min Ru Qiu, Asne R. Bauskin, S. Pankhurst, Paul M. G. Curmi, Terence J. Campbell, Stephen J. Harrop, Samuel N. Breit, W.D. Fairlie, Raffaella Tonini, Kristina Warton, Michele Mazzanti, Lucy Jankova, W.M. Wu
Publikováno v:
Journal of Biological Chemistry. 276:44993-45000
CLIC1 (NCC27) is a member of the highly conserved class of chloride ion channels that exists in both soluble and integral membrane forms. Purified CLIC1 can integrate into synthetic lipid bilayers forming a chloride channel with similar properties to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6aedd0fd2a1eab5b74e10444d03ad88
https://doi.org/10.1074/jbc.m107804200
https://doi.org/10.1074/jbc.m107804200