Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Terence F. Walker"'
Autor:
Thomas Henry Brown, C. Robin Ganellin, Graham J. Durant, Terence F. Walker, D.Anthony Rawlings, Michael E. Parsons, Robert Blakemore, John Colin Emmett
Publikováno v:
European Journal of Medicinal Chemistry. 23:53-62
A series of 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-4-pyrimidones was prepared based on cimetidine 1. The model compound 4 has modest H2-antagonist activity as shown by its ability to antagonise histamine-stimulated tachycardia in guinea pi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6496bc5c9b0ce79e58fbb39f35913f7f
https://doi.org/10.1016/0223-5234(88)90167-5
https://doi.org/10.1016/0223-5234(88)90167-5
Publikováno v:
Fundamental and Applied Toxicology. 8:188-197
Cimetidine has weak antiandrogenic activity in rats, but does not affect fertility in male rats at daily doses up to 950 mg/kg. Literature reports have claimed that giving cimetidine to pregnant rats in the drinking water caused feminization of male
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8184a9919717ad955041c560fec1fbf1
https://doi.org/10.1016/0272-0590(87)90117-5
https://doi.org/10.1016/0272-0590(87)90117-5
Publikováno v:
Toxicological Sciences. 8:188-197
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f09f87d5f7447a24e2f15818c434873
https://doi.org/10.1093/toxsci/8.2.188
https://doi.org/10.1093/toxsci/8.2.188
Autor:
G. J. Durant, Robert Blakemore, Terence F. Walker, Michael E. Parsons, A. C. Rasmussen, P. Blurton, Thomas Henry Brown, D. A. Rawlings, Charon R. Ganellin
Publikováno v:
European Journal of Medicinal Chemistry. 24:65-72
A series of 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-4-pyrimidones was synthesised based on oxmetidine 2 , in which the methylenedioxyphenyl group of 2 was replaced by a heterocyclic ring. Good H 2 -receptor antagonist activity was retained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e087314af44503cd3205a372c99ac1b
https://doi.org/10.1016/0223-5234(89)90166-9
https://doi.org/10.1016/0223-5234(89)90166-9
Autor:
T. H. Brown, D. A. Rawlings, Graham J. Durant, John Colin Emmett, R. C. Blakemore, Michael E. Parsons, C. R. Ganellin, Terence F. Walker
Publikováno v:
ChemInform. 19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a211fb6c74d73e1d225704f311ab45c
https://doi.org/10.1002/chin.198827181
https://doi.org/10.1002/chin.198827181