Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Terence F McGuire"'
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77675 (2013)
The development of an independent blood supply by a tumor is essential for maintaining growth beyond a certain limited size and for providing a portal for metastatic dissemination. Host-derived endothelial cells (ECs) residing in and compromising the
Externí odkaz:
https://doaj.org/article/05b50758fa5d4fb9b466cd92fbf0724d
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37138 (2012)
The growth of a malignant tumor beyond a certain, limited size requires that it first develop an independent blood supply. In addition to providing metabolic support, this neovasculature also allows tumor cells to access the systemic circulation, thu
Externí odkaz:
https://doaj.org/article/37ef1ad58a1e49c6a80a413973d05048
Publikováno v:
Biomolecules
Volume 11
Issue 6
Biomolecules, Vol 11, Iss 870, p 870 (2021)
Volume 11
Issue 6
Biomolecules, Vol 11, Iss 870, p 870 (2021)
G-protein-coupled receptors (GPCRs) are the largest and most diverse group of cell surface receptors that respond to various extracellular signals. The allosteric modulation of GPCRs has emerged in recent years as a promising approach for developing
Autor:
Heng Liu, Cheng Zhang, Xiang-Qun Xie, Terence F. McGuire, X. Edward Zhou, Karsten Melcher, Ying Xue, Changrui Xing, H. Eric Xu, Xing Meng, Maozi Chen, Ting-Hai Xu, Lei Wang, Gongpu Zhao, Junmei Wang, Youwen Zhuang, Zhiwei Feng
Publikováno v:
Cell
Drugs selectively targeting CB2 hold promise for treating neurodegenerative disorders, inflammation, and pain while avoiding psychotropic side effects mediated by CB1. The mechanisms underlying CB2 activation and signaling are poorly understood but c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a27e713de8a7bdd86ff9bfb13b9003c7
https://europepmc.org/articles/PMC8247115/
https://europepmc.org/articles/PMC8247115/
Autor:
Zhiwei Feng, Lirong Wang, Tao Cheng, Haizi Cheng, Yu Zhang, Yingdai Gao, Yahui Ding, Xiang-Qun Xie, Terence F. McGuire
Publikováno v:
Journal of Chemical Information and Modeling. 56:1995-2004
Given the capacity of self-renewal and multilineage differentiation, stem cells are promising sources for use in regenerative medicines as well as in the clinical treatment of certain hematological malignancies and degenerative diseases. Complex netw
Autor:
Ewa Galaj, Zheng-Xiong Xi, Ying Xue, Xiang-Qun Xie, Terence F. McGuire, Zhiwei Feng, Chloe J. Jordan, Guo-Hua Bi, Ying Liang
Publikováno v:
Neuropharmacology. 176:108241
Cocaine abuse remains a public health threat around the world. There are no pharmacological treatments approved for cocaine use disorder. Cannabis has received growing attention as a treatment for many conditions, including addiction. Most cannabis-b
Publikováno v:
Journal of neurotrauma. 36(4)
Traumatic brain injury (TBI) is associated with high mortality and morbidity. Though the death rate of initial trauma has dramatically decreased, no drug has been developed to effectively limit the progression of the secondary injury caused by TBI. T
Autor:
Tao Cheng, Liping Wang, Peng Zhang, Yahui Ding, Ming Yang, Terence F. McGuire, Weiping Yuan, Peng Yang, Qing Ji, Haizi Cheng, Yu Zhang, Xiang-Qun Xie, Qin Tong, Yingdai Gao
Publikováno v:
Scientific Reports
Hematopoietic stem cells (HSCs) have emerged as promising therapeutic cell sources for high-risk hematological malignancies and immune disorders. However, their clinical use is limited by the inability to expand these cells ex vivo. Therefore, there
Publikováno v:
International Journal of Cancer. 127:2268-2278
Tumor-associated endothelial cells (TAECs) harboring various genomic abnormalities have been described in human cancers although their origins remain obscure. We generated 4 human cancer cell lines tagged with multiple markers, grew them as xenograft
Autor:
Donald L. Trump, Ronald J. Bernardi, Candace S. Johnson, Pamela A. Hershberger, Terence F. McGuire
Publikováno v:
Urology. 60:123-130
Epidemiologic data suggest that low exposure to vitamin D or 1alpha,25-dihydroxycholecalciferol (calcitriol) increases the risk of prostate cancer. Calcitriol, a central factor in bone and mineral metabolism, is also a potent antiproliferative agent