Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Terence Davis"'
Autor:
Mark C. Bagley, Mohammed Baashen, Irina Chuckowree, Jessica E. Dwyer, David Kipling, Terence Davis
Publikováno v:
Pharmaceuticals, Vol 8, Iss 2, Pp 257-276 (2015)
Microwave-assisted Suzuki-Miyaura cross-coupling reactions have been employed towards the synthesis of three different MAPKAPK2 (MK2) inhibitors to study accelerated aging in Werner syndrome (WS) cells, including the cross-coupling of a 2-chloroquino
Externí odkaz:
https://doaj.org/article/8ba2c9fd6e5a45848730ec8b6ddd4744
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 6, p 1690 (2018)
Chemotherapeutic drugs target a physiological differentiating feature of cancer cells as they tend to actively proliferate more than normal cells. They have well-known side-effects resulting from the death of highly proliferative normal cells in the
Externí odkaz:
https://doaj.org/article/ac024e3b817449a497dcfc9b65d287a1
Publikováno v:
Pharmaceuticals, Vol 3, Iss 6, Pp 1842-1872 (2010)
Werner syndrome provides a convincing model for aspects of the normal ageing phenotype and may provide a suitable model for therapeutic interventions designed to combat the ageing process. Cultured primary fibroblast cells from Werner syndrome patien
Externí odkaz:
https://doaj.org/article/32a9b9c9df10438ab25a5298d558f3b7
Publikováno v:
Pharmaceuticals, Vol 9, Iss 2, p 23 (2016)
Progeroid syndromes show features of accelerated ageing and are used as models for human ageing, of which Werner syndrome (WS) is one of the most widely studied. WS fibroblasts show accelerated senescence that may result from p38 MAP kinase activatio
Externí odkaz:
https://doaj.org/article/3310edc11c814827b45083d157077305
Autor:
Rob Knight, Emma Board-Davies, Helen Brown, Aled Clayton, Terence Davis, Ben Karatas, James Burston, Zsuzsanna Tabi, Juan M Falcon-Perez, Stephen Paisey, Phil Stephens
Scar formation during wound repair can be devastating for affected individuals. Our group previously documented the therapeutic potential of novel progenitor cell populations from the non-scarring buccal mucosa. These Oral Mucosa Lamina Propria-Proge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f2ace7819eccc13eeebe661023f3db7
https://orca.cardiff.ac.uk/id/eprint/150847/1/szac037.pdf
https://orca.cardiff.ac.uk/id/eprint/150847/1/szac037.pdf
Autor:
Yuliya Safarova, Aiym Kaiyrlykyzy, Andrey Tsoy, Abdul-Razak Masoud, Alla Shramko, Sholpan Askarova, Terence Davis, Bauyrzhan Umbayev, Dauren Alimbetov, Farkhad Olzhayev
Mesenchymal stem cells (MSCs) represent a promising cell source for cellular therapy and tissue engineering and are currently being tested in a number of clinical trials for various diseases. However, like other somatic cells, MSCs age, and this sene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1d36bbdc8c58b33b885d6c5fb38de80
https://orca.cardiff.ac.uk/id/eprint/111827/1/DavisBG2018.pdf
https://orca.cardiff.ac.uk/id/eprint/111827/1/DavisBG2018.pdf
Autor:
Richard G. A. Faragher, Talgat Nurgozhin, Amy Jayne Chedzoy Brook, Lynne S. Cox, Terence Davis, David Glyn Kipling, Dauren Alimbetov, Zhaxybay Zhumadilov
Publikováno v:
Biogerontology
Senescent cells show an altered secretome profile termed the senescence-associated secretory phenotype (SASP). There is an increasing body of evidence that suggests that the accumulation of SASP-positive senescent cells in humans is partially causal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754fbfb5b4b497d1a05597c45e0255e5
https://doi.org/10.1007/s10522-015-9610-z
https://doi.org/10.1007/s10522-015-9610-z
Autor:
Dwyer Jessica, Milbeo Pierre, Terence Davis, Baashen Mohammed, Bagley Mark, David Glyn Kipling
Publikováno v:
Microwaves in Drug Discovery and Development: Recent Advances. :86-104
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84c63334cb21caa046360fcfb4f52a2a
https://doi.org/10.4155/fseb2013.13.130
https://doi.org/10.4155/fseb2013.13.130
Publikováno v:
Biogerontology
Fibroblasts from the progeroid Nijmegen breakage syndrome that express a truncated version of the nibrin protein (NBNp70) undergo premature senescence and have an enlarged morphology with high levels of senescence-associated β-galactosidase, althoug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c3a4450abf5d11b8d32fc2e31c5835
https://doi.org/10.1007/s10522-014-9530-3
https://doi.org/10.1007/s10522-014-9530-3
Autor:
Terence Davis, Alan Bernjak, Peter V. E. McClintock, Mark C. Bagley, Joanna Elizabeth Latimer, Jane Upton, Lynne S. Cox, Penelope A. Mason, David Steinsaltz, Anna C. Phillips, Aneta Stefanovska
Publikováno v:
The New Science of Ageing ISBN: 9781447314684
In this chapter, we discuss how social and biological studies of ageing can converge to provide a meaningful framework for progress in both understanding ageing and dealing with it in a positive manner. We start by discussing the meaning of the term
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91fdbb178d354e8dd7154ecd4ad2cac0
https://doi.org/10.46692/9781447314684.002
https://doi.org/10.46692/9781447314684.002