Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Terence D Capellini"'
Autor:
Daniel Richard, Steven Pregizer, Divya Venkatasubramanian, Rosanne M Raftery, Pushpanathan Muthuirulan, Zun Liu, Terence D Capellini, April M Craft
Publikováno v:
eLife, Vol 12 (2023)
To address large gaps in our understanding of the molecular regulation of articular and growth plate cartilage development in humans, we used our directed differentiation approach to generate these distinct cartilage tissues from human embryonic stem
Externí odkaz:
https://doaj.org/article/366aba9684e84cb293c4642ab52790f1
Autor:
Evelyn Jagoda, Davide Marnetto, Gayani Senevirathne, Victoria Gonzalez, Kaushal Baid, Francesco Montinaro, Daniel Richard, Darryl Falzarano, Emmanuelle V LeBlanc, Che C Colpitts, Arinjay Banerjee, Luca Pagani, Terence D Capellini
Publikováno v:
eLife, Vol 12 (2023)
Individuals infected with the SARS-CoV-2 virus present with a wide variety of symptoms ranging from asymptomatic to severe and even lethal outcomes. Past research has revealed a genetic haplotype on chromosome 3 that entered the human population via
Externí odkaz:
https://doaj.org/article/39bebb50ae4f4e91aaf3db376ba9bbd1
Autor:
Shiri Kult, Tsviya Olender, Marco Osterwalder, Svetalana Markman, Dena Leshkowitz, Sharon Krief, Ronnie Blecher-Gonen, Shani Ben-Moshe, Lydia Farack, Hadas Keren-Shaul, Tomer-Meir Salame, Terence D Capellini, Shalev Itzkovitz, Ido Amit, Axel Visel, Elazar Zelzer
Publikováno v:
eLife, Vol 10 (2021)
The mechanical challenge of attaching elastic tendons to stiff bones is solved by the formation of a unique transitional tissue. Here, we show that murine tendon-to-bone attachment cells are bi-fated, activating a mixture of chondrocyte and tenocyte
Externí odkaz:
https://doaj.org/article/d634c0b6552b4485bd6640c59f2a7db5
Autor:
Abbey C Thompson, Terence D Capellini, Catherine A Guenther, Yingguang Frank Chan, Carlos R Infante, Douglas B Menke, David M Kingsley
Publikováno v:
eLife, Vol 7 (2018)
Vertebrate pelvic reduction is a classic example of repeated evolution. Recurrent loss of pelvic appendages in sticklebacks has previously been linked to natural mutations in a pelvic enhancer that maps upstream of Pitx1. The sequence of this upstrea
Externí odkaz:
https://doaj.org/article/f5d81636d51f408b89dd979d4f375988
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0202785 (2018)
Given GDF5 involvement in hip development, and osteoarthritis (OA) and developmental hip dysplasia (DDH) risk, here we sought to assess the role(s) of GDF5 and its regulatory sequence on the development of hip morphology linked to injury risk. The br
Externí odkaz:
https://doaj.org/article/46787b910a5c4bb591f3ba0f911b916f
Autor:
Michael Guo, Zun Liu, Jessie Willen, Cameron P Shaw, Daniel Richard, Evelyn Jagoda, Andrew C Doxey, Joel Hirschhorn, Terence D Capellini
Publikováno v:
eLife, Vol 6 (2017)
GWAS have identified hundreds of height-associated loci. However, determining causal mechanisms is challenging, especially since height-relevant tissues (e.g. growth plates) are difficult to study. To uncover mechanisms by which height GWAS variants
Externí odkaz:
https://doaj.org/article/8f603b92444e499599c4d55217f0523c
Autor:
Hao Chen, Terence D Capellini, Michael Schoor, Doug P Mortlock, A Hari Reddi, David M Kingsley
Publikováno v:
PLoS Genetics, Vol 12, Iss 11, p e1006454 (2016)
Synovial joints are crucial for support and locomotion in vertebrates, and are the frequent site of serious skeletal defects and degenerative diseases in humans. Growth and differentiation factor 5 (Gdf5) is one of the earliest markers of joint forma
Externí odkaz:
https://doaj.org/article/d1254b1dde1845db99ceecc09f818bbc
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148899 (2016)
Prolonged human interactions and artificial selection have influenced the genotypic and phenotypic diversity among dog breeds. Because humans and dogs occupy diverse habitats, ecological contexts have likely contributed to breed-specific positive sel
Externí odkaz:
https://doaj.org/article/579abed9cf344e90bf2f70b3feaad511
Autor:
Philip L Reno, Cory Y McLean, Jasmine E Hines, Terence D Capellini, Gill Bejerano, David M Kingsley
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84258 (2013)
Previous studies show that humans have a large genomic deletion downstream of the Androgen Receptor gene that eliminates an ancestral mammalian regulatory enhancer that drives expression in developing penile spines and sensory vibrissae. Here we use
Externí odkaz:
https://doaj.org/article/b9e1ce54445f498db1bbdd5ebd2760d2
Publikováno v:
American Journal of Physiology-Cell Physiology. 324:C1078-C1088
The identification of genomic loci that are associated with osteoarthritis (OA) has provided a starting point for understanding how genetic variation activates catabolic processes in the joint. However, genetic variants can only alter gene expression