Zobrazeno 1 - 10 of 46 pro vyhledávání: '"Terence C. Owen"'
1
Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine α-hydroxylating monooxygenase (PHM)
Autor: Robert D. Kendig, David J. Merkler, Robert Malka, Geoffrey H. Chew, Kathleen A. Merkler, Benjamin J. Wilcox, Jodi Dusi, Casey C. Cosner, Neil R. McIntyre, Edward W. Lowe, Paul C. Kline, Lamar Galloway, Mindy Romero, Natalie Carballo, Laura E. Baumgart, Lawrence King, Sarah E. Carpenter, Alexander S. Asser, Terence C. Owen, Andrew B. Lowe
Publikováno v: Bioorganic & Medicinal Chemistry. 16:10061-10074
Peptidyl alpha-hydroxylating monooxygenase (PHM) functions in vivo towards the biosynthesis of alpha-amidated peptide hormones in mammals and insects. PHM is a potential target for the development of inhibitors as drugs for the treatment of human dis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdc0d70b47e353d7badde8f5565e5dcd
https://doi.org/10.1016/j.bmc.2008.10.013
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2
Thiol detection, derivatization and tagging at micromole to nanomole levels using propiolates
Autor: Terence C. Owen
Publikováno v: Bioorganic Chemistry. 36:156-160
Thiols, simple and complex, including polypeptide and protein thiols, react rapidly and selectively with esters of propiolic acid under very mild conditions (aqueous buffer, room temperature, pH 7) to give thioacrylates. These stable derivatives exhi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57b7cdb979532f14ec454bf3e7d80724
https://doi.org/10.1016/j.bioorg.2008.02.003
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3
The regulation of rhinovirus infection in vitro by IL-8, HuIFN-alpha, and TNF-alpha
Autor: Terence C. Owen, Henning Andersen, Kurt Berg
Publikováno v: Berg, K, Andersen, H & Owen, T C 2004, ' The regulation of rhinovirus infection in vitro by IL-8, HuIFN-alpha, and TNF-alpha ', APMIS Supplementum, vol. 112, no. 3, pp. 172-82 . https://doi.org/10.1111/j.1600-0463.2004.apm1120303.x
The influence of three important cytokines (IL-8, TNF-alpha, and HuIFN-alpha) on ongoing rhinovirus infections has been examined in vitro, individually or as combinations. TNF-alpha was able to transform traces of HRV infections into full-blown infec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a31ade231f68dfcb067c4945a54f2dab
https://doi.org/10.1111/j.1600-0463.2004.apm1120303.x
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4
Use of an aqueous soluble tetrazolium/formazan assay to measure viability and proliferation of lymphokine-dependent cell lines
Autor: Thomas M. Buttke, James A. McCubrey, Terence C. Owen
Publikováno v: Journal of Immunological Methods. 157:233-240
A new tetrazolium compound, MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3- carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt), has recently been described which in the presence of phenazine methosulfate (PMS) is reduced by living cells to y
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b87bf732c16c3809439e2bea9ce751
https://doi.org/10.1016/0022-1759(93)90092-l
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5
Rapid colorimetric bioassay for screening of fusarium mycotoxins
Autor: Terence C. Owen, B. K. Thompson, B. A. Rotter, Sylvia Clarkin
Publikováno v: Natural Toxins. 1:303-307
The cytotoxicity of Fusarium mycotoxins was evaluated using a trichothecene sensitive cell line (BHK-21, baby hamster kidney cells) in combination with the MTT-cleavase test as an end-point measurement. Cells tended to be more sensitive to the type A
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dfe68c1fe6bf5974d6144b875367f7a
https://doi.org/10.1002/nt.2620010509
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7
Acidity constants of benzimidazolium ketone and pyridinium aldehyde hydrates
Autor: Terence C. Owen
Publikováno v: Journal of Heterocyclic Chemistry. 27:987-990
Acidity constants (pKa) of the hydroxyl groups of the quaternary heterocyclonium carbinols 2-hydroxymethyl-1-methylpyridinium and 2-(1-hydroxyethyl)-1,3-dimethylbenzimidazolium ions are 11.5 ± 0.5. Acidity constants of the corresponding gem diols, t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1bc7af03f4194bad700a5b7b891175cc
https://doi.org/10.1002/jhet.5570270431
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8
A new proposal for the mechanism of glycine hydroxylation as catalyzed by peptidylglycine alpha-hydroxylating monooxygenase (PHM)
Autor: David J. Merkler, Terence C. Owen
Publikováno v: Medical hypotheses. 62(3)
The title enzyme, peptidylglycine alpha-hydroxylating monooxygenase (PHM), is essential to the in vivo generation of a wide variety of physiologically significant alpha-amidated peptide hormones from the corresponding C-terminal glycine-extended proh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e2a82f8ffd98dac599b46a28f9af68b
https://pubmed.ncbi.nlm.nih.gov/14975510
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10
Zinc potentiates the antiviral action of human IFN-alpha tenfold
Autor: Terence C. Owen, Kurt Berg, Gert Bolt, Henning Andersen
Publikováno v: Journal of interferoncytokine research : the official journal of the International Society for Interferon and Cytokine Research. 21(7)
During the last decade, various zinc salts have been used against the common cold syndrome, which is known to be initiated by respiratory viruses, particularly rhinoviruses. Using rhinovirus as the challenge virus, we investigated whether zinc salts
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d352b97d3a615e2f90ff141020d3fad3
https://pubmed.ncbi.nlm.nih.gov/11506740
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