Multidimensional profiling of human T cells reveals high CD38 expression, marking recent thymic emigrants and age-related naive T cell remodeling.

Autor: Bohacova P; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Terekhova M; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Tsurinov P; JetBrains Research, Paphos 8021, Cyprus., Mullins R; Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA., Husarcikova K; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Shchukina I; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Antonova AU; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Echalar B; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Kossl J; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Saidu A; Department of Emergency Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA., Francis T; Centre for Human and Applied Physiological Sciences, School of Basic and Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London SE1 1UL, UK., Mannie C; Division of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA., Arthur L; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Harridge SDR; Centre for Human and Applied Physiological Sciences, School of Basic and Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London SE1 1UL, UK., Kreisel D; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA., Mudd PA; Department of Emergency Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology & Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, St. Louis, MO 63110, USA., Taylor AM; Department of Medicine, Cardiovascular Division, University of Virginia, Charlottesville, VA 22903, USA., McNamara CA; Department of Medicine, Cardiovascular Division, University of Virginia, Charlottesville, VA 22903, USA; Beirne B. Carter Center for Immunology Research, University of Virginia, Charlottesville, VA 22903, USA., Cella M; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Puram SV; Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA; Rob Ebert and Greg Stubblefield Head and Neck Tumor Center at Siteman Cancer Center, St. Louis, MO 63110, USA., van den Broek T; Center for Translational Immunology, University Medical Centre Utrecht, Utrecht University, Utrecht 3584CX, the Netherlands., van Wijk F; Center for Translational Immunology, University Medical Centre Utrecht, Utrecht University, Utrecht 3584CX, the Netherlands., Eghtesady P; Division of Cardiothoracic Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA., Artyomov MN; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: martyomov@wustl.edu.

Publikováno v: Immunity [Immunity] 2024 Oct 08; Vol. 57 (10), pp. 2362-2379.e10. Date of Electronic Publication: 2024 Sep 24.

Rapid unleashing of macrophage efferocytic capacity via transcriptional pause release.

Autor: Tufan T; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Comertpay G; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Villani A; Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland., Nelson GM; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Terekhova M; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Kelley S; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Zakharov P; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Ellison RM; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Shpynov O; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.; JetBrains Research, Munich, Germany., Raymond M; Department of Neuroscience and MIC, University of Virginia, Charlottesville, VA, USA., Sun J; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Chen Y; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Bockelmann E; Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland., Stremska M; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Peterson LW; Department of Pediatrics, Division of Rheumatology and Immunology, Washington University in St. Louis, St. Louis, MO, USA., Boeckaerts L; Unit for Cell Clearance in Health and Disease, VIB-UGent Center for Inflammation Research and the Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium., Goldman SR; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Etchegaray JI; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Artyomov MN; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA., Peri F; Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland., Ravichandran KS; Division of Immunobiology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA. kodi@wustl.edu.; Department of Neuroscience and MIC, University of Virginia, Charlottesville, VA, USA. kodi@wustl.edu.; Unit for Cell Clearance in Health and Disease, VIB-UGent Center for Inflammation Research and the Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium. kodi@wustl.edu.

Publikováno v: Nature [Nature] 2024 Apr; Vol. 628 (8007), pp. 408-415. Date of Electronic Publication: 2024 Mar 13.

Single-cell atlas of healthy human blood unveils age-related loss of NKG2C ⁺ GZMB ^- CD8 ⁺ memory T cells and accumulation of type 2 memory T cells.

Autor: Terekhova M; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA., Swain A; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA., Bohacova P; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA., Aladyeva E; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA., Arthur L; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA., Laha A; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA., Mogilenko DA; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Medicine, Department of Pathology, Microbiology, and Immunology, Vanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Burdess S; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA., Sukhov V; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Computer Technologies Laboratory, ITMO University, Saint Petersburg 197101, Russia., Kleverov D; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Computer Technologies Laboratory, ITMO University, Saint Petersburg 197101, Russia., Echalar B; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA., Tsurinov P; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; JetBrains Research, 8021 Paphos, Cyprus., Chernyatchik R; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; JetBrains Research, 80639 Munich, Germany., Husarcikova K; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA., Artyomov MN; Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address: martyomov@wustl.edu.

Publikováno v: Immunity [Immunity] 2023 Dec 12; Vol. 56 (12), pp. 2836-2854.e9. Date of Electronic Publication: 2023 Nov 13.

Accessory fimbrial subunits and PPAD are necessary for TLR2 activation by Porphyromonas gingivalis.

Autor: Wielento A; Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland., Bereta GP; Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland., Szczęśniak K; Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland., Jacuła A; Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland., Terekhova M; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, Missouri, USA., Artyomov MN; Department of Pathology and Immunology, Division of Immunobiology, Washington University School of Medicine, St. Louis, Missouri, USA., Hasegawa Y; Department of Microbiology, School of Dentistry, Aichi Gakuin University, Nagoya, Japan., Grabiec AM; Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland., Potempa J; Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.; Department of Oral Immunology and Infectious Diseases, School of Dentistry, University of Louisville, Louisville, Kentucky, USA.

Publikováno v: Molecular oral microbiology [Mol Oral Microbiol] 2023 Aug; Vol. 38 (4), pp. 334-346. Date of Electronic Publication: 2023 Jun 22.

Transcriptomic atlas and interaction networks of brain cells in mouse CNS demyelination and remyelination.

Autor: Hou J; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Zhou Y; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Cai Z; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Terekhova M; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Swain A; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Andhey PS; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Guimaraes RM; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Ribeirão Preto Medical School, University of São Paulo - Ribeirão Preto, São Paulo 14049-900, Brazil., Ulezko Antonova A; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Qiu T; Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA., Sviben S; Washington University Center for Cellular Imaging, Washington University School of Medicine, St. Louis, MO 63110, USA., Strout G; Washington University Center for Cellular Imaging, Washington University School of Medicine, St. Louis, MO 63110, USA., Fitzpatrick JAJ; Washington University Center for Cellular Imaging, Washington University School of Medicine, St. Louis, MO 63110, USA; Departments of Cell Biology and Physiology and Neuroscience, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63110, USA., Chen Y; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA., Gilfillan S; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Kim DH; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Van Dyken SJ; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Artyomov MN; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA., Colonna M; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: mcolonna@wustl.edu.

Publikováno v: Cell reports [Cell Rep] 2023 Apr 25; Vol. 42 (4), pp. 112293. Date of Electronic Publication: 2023 Mar 21.