Systematic visualisation of molecular QTLs reveals variant mechanisms at GWAS loci.

Autor: Kerimov N; Institute of Computer Science, University of Tartu, Tartu, 51009, Estonia.; Open Targets, South Building, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK., Tambets R; Institute of Computer Science, University of Tartu, Tartu, 51009, Estonia., Hayhurst JD; Open Targets, South Building, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK., Rahu I; Institute of Computer Science, University of Tartu, Tartu, 51009, Estonia., Kolberg P; Institute of Computer Science, University of Tartu, Tartu, 51009, Estonia., Raudvere U; Institute of Computer Science, University of Tartu, Tartu, 51009, Estonia., Kuzmin I; Institute of Computer Science, University of Tartu, Tartu, 51009, Estonia., Chowdhary A; Institute of Translational Genomics, Helmholtz Munich, Neuherberg, Germany., Vija A; Institute of Computer Science, University of Tartu, Tartu, 51009, Estonia., Teras HJ; Institute of Computer Science, University of Tartu, Tartu, 51009, Estonia., Kanai M; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ulirsch J; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ryten M; Department of Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London., Hardy J; Department of Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London., Guelfi S; Department of Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London., Trabzuni D; Department of Genetics and Genomic Medicine, Great Ormond Street Institute of Child Health, University College London, London., Kim-Hellmuth S; Institute of Translational Genomics, Helmholtz Munich, Neuherberg, Germany.; Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital LMU Munich, Munich, Germany., Rayner W; Institute of Translational Genomics, Helmholtz Munich, Neuherberg, Germany., Finucane H; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Peterson H; Institute of Computer Science, University of Tartu, Tartu, 51009, Estonia., Mosaku A; Open Targets, South Building, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK., Parkinson H; Open Targets, South Building, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK., Alasoo K; Institute of Computer Science, University of Tartu, Tartu, 51009, Estonia.; Open Targets, South Building, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Apr 07. Date of Electronic Publication: 2023 Apr 07.