Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Teppei Niide"'
Autor:
Aruto Sugiyama, Mitsuo Umetsu, Hikaru Nakazawa, Teppei Niide, Tomoko Onodera, Katsuhiro Hosokawa, Shuhei Hattori, Ryutaro Asano, Izumi Kumagai
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Small bispecific antibodies that induce T-cell–mediated cytotoxicity have the potential to damage late-stage tumor masses to a clinically relevant degree, but their cytotoxicity is critically dependent on their structural and functional pr
Externí odkaz:
https://doaj.org/article/f18cb9ec074743a0b52efdd168550715
Publikováno v:
Journal of Bioscience and Bioengineering. 135:291-297
Publikováno v:
ACS Synthetic Biology. 11:3973-3985
Changing the substrate/cofactor specificity of an enzyme requires multiple mutations at spatially adjacent positions around the substrate pocket. However, this is challenging when solely based on crystal structure information because enzymes undergo
Autor:
Ryutaro Kawai, Yoshihiro Toya, Kenta Miyoshi, Manami Murakami, Teppei Niide, Takaaki Horinouchi, Tomoya Maeda, Atsushi Shibai, Chikara Furusawa, Hiroshi Shimizu
Publikováno v:
Biotechnology and Bioengineering. 119:936-945
Co-culture is a promising way to alleviate metabolic burden by dividing the metabolic pathways into several modules and sharing the conversion processes with multiple strains. Since an intermediate is passed from the donor to the recipient via the ex
Autor:
Gabriela Kratošová, Marek Kolenčcík, Veronika Holišová, Zuzana Konvičcková, Daniela Plachá, Mitsuo Umetsu, Teppei Niide
Publikováno v:
Journal of Nanoscience and Nanotechnology. 19:2807-2813
Due to its easy availability, preparation, handling and non-toxic nature, Equisetum arvense horsetail extract was chosen as a reducing, stabilizing and functionalizing agent for Au and bi-phasic Au/ZrO₂ nanoparticle phytosynthesis-inorganic nanopar
Autor:
Mitsuo Umetsu, Jana Seidlerová, Gabriela Kratošová, Zuzana Konvičková, Veronika Holišová, Marek Kolenčík, Teppei Niide
Publikováno v:
Colloid and Polymer Science. 296:677-687
Our hypothesis introduced (i) Tilia sp. leachate as the basic platform for Ag-AgCl nanoparticle phytosynthesis as a new bionanotechnological protocol, (ii) determination of Ag-AgCl colloidal properties during periodic temperature changes and (iii) co
Autor:
Kazuto Akagi, Teppei Niide, Hikaru Nakazawa, Takamitsu Hattori, Mitsuo Umetsu, Izumi Kumagai, Noriyoshi Manabe
Publikováno v:
Langmuir : the ACS journal of surfaces and colloids. 35(8)
Recent advances in biotechnology have enabled the generation of antibodies with high affinity for the surfaces of specific inorganic materials. Herein, we report the synthesis of functional materials from multiple nanomaterials by using a small bispe
Autor:
Veronika, Holišová, Zuzana, Konvičcková, Gabriela, Kratošová, Marek, Kolenčcík, Teppei, Niide, Mitsuo, Umetsu, Daniela, Plachá
Publikováno v:
Journal of nanoscience and nanotechnology. 19(5)
Due to its easy availability, preparation, handling and non-toxic nature
Autor:
Mitsuo Umetsu, Tomoko Onodera-Sugano, Ryutaro Asano, Yoshikazu Tanaka, Izumi Kumagai, Hikaru Nakazawa, Aruto Sugiyama, Teppei Niide, Takamitsu Hattori, Hiromi Ogata
Publikováno v:
Biochemical Engineering Journal. 160:107636
Diabody 31, a bispecific therapeutic antibody, is a heterodimer comprised of two types of chimeric single-chain variable fragments (scFv), that has been identified as a clone with high cytotoxicity against cancer cells. Diabody 31 is inactive as a ho
Autor:
Misaki Oikawa, Yutaka Saito, Teppei Niide, Hikaru Nakazawa, Tomoshi Kameda, Mitsuo Umetsu, Koji Tsuda
Publikováno v:
ACS synthetic biology. 7(9)
Molecular evolution based on mutagenesis is widely used in protein engineering. However, optimal proteins are often difficult to obtain due to a large sequence space. Here, we propose a novel approach that combines molecular evolution with machine le