Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Teppei Kaku"'
Autor:
Teppei Kaku, Miiru Suzuki, Takanari Tominaga, Akio Ogawa, Atsushi Shimizu, Kazutaka Watanabe, Kazuaki Watanabe, Tomoji Maeda, Yoshikazu Matsuda
Publikováno v:
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 142(3)
In recent years, lifestyle-related diseases such as hypertension and diabetes have been on the rise. These conditions can cause serious conditions such as myocardial and cerebral infarctions. Therefore, proper control of blood pressure and blood gluc
Autor:
Koji Sekine, Kenichiro Ogura, Akira Hiratsuka, Yasunari Ohkubo, Tadashi Watabe, Takahito Nishiyama, Hiroaki Nakano, Shigetoshi Kadota, Teppei Kaku, Eriko Takahashi
Publikováno v:
Drug Metabolism and Pharmacokinetics. 17:221-228
Summary: It is known that in humans taking soy food, the phytoestrogens, daidzein (DZ) and genistein (GS), exist as sulfates and glucuronides in the plasma and are excreted as conjugates in urine. To investigate which human sulfotransferase (SULT) is
Autor:
Yoshiko Furukawa, Koichi Murase, Mitsunari Nakajima, Shoei Furukawa, Makiko Okada, Teppei Kaku, Akihisa Makino
Publikováno v:
Biomedical research (Tokyo, Japan). 29(3)
We investigated the effect of the female hormone 17beta-estradiol (E2) and the hormone mimic bisphenol A (BPA) on the proliferation and differentiation of rat neural stem/progenitors cells (NS/PCs) cultured from the telencephalon of embryonic day-15
Autor:
Tomokazu Ohnuma, Takahito Nishiyama, Kenichiro Ogura, Yuko Ishikawa, Kei Muro, Teppei Kaku, Akira Hiratsuka
Publikováno v:
Biochemical pharmacology. 71(9)
Tamoxifen (TAM), a nonsteroidal antiestrogen, is the most widely used drug for chemotherapy of hormone-dependent breast cancer in women. Trans-4-hydroxy-TAM (trans-4-HO-TAM), one of the TAM metabolites in humans, has been considered to be an active m
Autor:
Akira Hiratsuka, Kenichiro Ogura, Takahito Nishiyama, Kei Muro, Tomokazu Ohnuma, Teppei Kaku, Hiroaki Nakano, Tadashi Watabe
Publikováno v:
Biochemical pharmacology. 63(10)
The phenolic active metabolites, cis-4-hydroxytamoxifen (cis-HO-TAM) and trans-4-hydroxytamoxifen (trans-HO-TAM), of the anti-breast-cancer drug, trans-tamoxifen (TAM), were geometrically selectively glucuronidated in the manner of cis>>trans by micr