Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Teppei Fujimoto"'
Autor:
Teppei Fujimoto
Publikováno v:
Sportstättenbau + Bäderanlagen (sb); 2023, Vol. 57 Issue 5, p64-67, 4p
Autor:
Tetsuji Noguchi, Yuki Domon, Koichi Yabe, Teppei Fujimoto, Rieko Takano, Yumi Kawase, Kazufumi Kubota, Umezaki Yuma, Miki Yokoyama, Kousei Shimada, Kenjiro Ueda
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 36:127790
We identified (5R)-6-methyl-5-phenyl-1,3,4,5,6,7-hexahydro-2,5-methano-2,6-benzodiazonine (DS21980956: 4-(R)) as a novel [5.2.1]bicyclic basic compound. The scaffold was inspired by fentanyl or pethidine, which possess potent analgesic activities. DS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::134edc323b8d63075394ef43fac0a4d1
https://doi.org/10.1016/j.bmcl.2021.127790
https://doi.org/10.1016/j.bmcl.2021.127790
Publikováno v:
Organic Process Research & Development
We report a practical synthesis method of the reagent PhenoFluor on decagram scale, provide a new formulation of PhenoFluor as a toluene solution, which should decrease challenges associated with the moisture sensitivity of the reagent, and expand th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40f9a7e601b2c09311eac4afc22959e1
https://doi.org/10.1021/op500121w
https://doi.org/10.1021/op500121w
Autor:
Takashi Hara, Youko Nagai, Tsuyoshi Arita, Masanori Izumi, Asuka Kawamura, Tetsuyoshi Matsufuji, Kousei Shimada, Rie Abe-Ohya, Masahiro Konishi, Yoshitaka Sogawa, Shozo Kobayashi, Hisashi Takahashi, Teppei Fujimoto, Kazuhiro Yoshida
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:750-755
The discovery and optimization of a novel series of BRS-3 agonists are described. We explored a potent BRS-3 agonist with low brain penetration to avoid an adverse effect derived from central nervous system exposure. Through the derivatization proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5741d3e76e545402bbd72c424dcc1367
https://doi.org/10.1016/j.bmcl.2013.12.106
https://doi.org/10.1016/j.bmcl.2013.12.106
Autor:
Yoshitaka Hamashima, Tomohiro Asakawa, Teppei Fujimoto, Toshiyuki Kan, Hiraku Mimura, Yoshinori Yasuda, Tohru Fukuyama, Takahiro Ogawa, Kenji Uchida, Toshiyuki Wakimoto
Publikováno v:
Angewandte Chemie. 124:13022-13025
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d58e55cc77b4cd77b7196c9a75e33310
https://doi.org/10.1002/ange.201207800
https://doi.org/10.1002/ange.201207800
Autor:
Takahiro Nagayama, Takahide Nishi, Chie Sugita, Kazuhiko Tamaki, Yumi Matsui, Teppei Fujimoto, Kenichi Manabe, Ogawa Yasuyuki, Katsuyoshi Chiba, Noriko Masubuchi, Mizuki Takahashi, Shojiro Miyazaki, Makoto Mizuno, Yuji Nakamura
Publikováno v:
ACS Medicinal Chemistry Letters. 3:754-758
A novel orally bioavailable renin inhibitor, DS-8108b (5), showing potent renin inhibitory activity and excellent in vivo efficacy is described. We report herein the synthesis and pharmacological effects of 5 including renin inhibitory activity in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4768bdbd470e9703d3327b13364269d1
https://doi.org/10.1021/ml300168e
https://doi.org/10.1021/ml300168e
Autor:
Teppei Fujimoto, Tobias Ritter
Publikováno v:
ChemInform. 46
The novel reagent PhenoFluorMix is applied to the scalable deoxyfluorination of various phenols and hetaromatic derivatives thereof as well as of natural products such as steroids and hydroxycinchonidines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa482f11158cea6aac4d83cec6f2aebf
https://doi.org/10.1002/chin.201525084
https://doi.org/10.1002/chin.201525084
Autor:
Teppei Fujimoto, Tobias Ritter
Publikováno v:
Organic letters. 17(3)
A practical deoxyfluorination with novel deoxyfluorinating reagent PhenoFluorMix, a mixture of N,N'-1,3-bis(2,6-diisopropylphenyl)chloroimidazolium chloride and CsF, is presented. PhenoFluorMix overcomes the challenges associated with hydrolysis of P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::957a2f6f858e7c2fdb851b1ba84358e7
https://pubmed.ncbi.nlm.nih.gov/25619627
https://pubmed.ncbi.nlm.nih.gov/25619627
Autor:
Shojiro Miyazaki, Kazuhiko Tamaki, Chie Sugita, Yoko Nagai, Teppei Fujimoto, Akiyoshi Mochizuki, Yuji Nakamura, Takahiro Nagayama, Shin-ichi Inoue, Katsuyoshi Chiba, Yutaka Mori, Ogawa Yasuyuki, Takahide Nishi
Publikováno v:
Bioorganicmedicinal chemistry. 21(18)
We report synthesis and optimization of a series of (3 S ,5 R )-5-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as renin inhibitors. Chemical modification of P 1 ′ P 1 ′ , P 2 ′ P 2 ′ and P 3 portions led to a promising
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac05d37920ab5fe40c29f42029464b7a
https://pubmed.ncbi.nlm.nih.gov/23886807
https://pubmed.ncbi.nlm.nih.gov/23886807
Autor:
Kazuhiko Tamaki, Akiyoshi Mochizuki, Kiyoshi Takasuna, Katsuyoshi Chiba, Chie Sugita, Takahide Nishi, Ogawa Yasuyuki, Teppei Fujimoto, Yoko Nagai, Masayoshi Asano, Mikio Kato, Hidenori Namiki, Takahiro Nagayama, Yuji Nakamura, Sayaka Suzuki, Shin-ichi Inoue, Shojiro Miyazaki
Publikováno v:
Bioorganicmedicinal chemistry. 21(11)
With the aim to address an undesired cardiac issue observed with our related compound in the recently disclosed novel series of renin inhibitors, further chemical modifications of this series were performed. Extensive structure–activity relationshi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae969f2c225e0ab720b893eeee0aa97f
https://pubmed.ncbi.nlm.nih.gov/23598247
https://pubmed.ncbi.nlm.nih.gov/23598247