Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Tepoxalin"'
Autor:
Ranad Humeidi, Matthew Meyerson, Anna Tang, Ryan Spangler, Mustafa Kocak, Aviad Tsherniak, Philip Montgomery, Jordan Rossen, Todd R. Golub, Jordan Bryan, Vickie M. Wang, David Peck, Jesse S. Boehm, Heidi Greulich, Bang Wong, Xiaoyun Wu, John G. Doench, Patrick O'Hearn, Rohith T. Nagari, Uri Ben-David, Yii-Der Ida Chen, Caitlin N. Harrington, Eric Stefan, Evan Lemire, Sam Bender, Matthew G. Rees, Colin W. Garvie, Jennifer Roth, Joshua Bittker, James M. McFarland, Steven M. Corsello, Christopher C. Mader, Francisca Vazquez, Nicholas J. Lyons, Nancy Dumont, Rajiv Narayan, Ayshwarya Subramanian, Li Wang
Publikováno v:
Nature Cancer. 1:235-248
Anti-cancer uses of non-oncology drugs have occasionally been found, but such discoveries have been serendipitous. We sought to create a public resource containing the growth inhibitory activity of 4,518 drugs tested across 578 human cancer cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4cffd5ffd9046dd230ac8923ff8c9d8
https://doi.org/10.1038/s43018-019-0018-6
https://doi.org/10.1038/s43018-019-0018-6
Publikováno v:
Translational Oncology, Vol 14, Iss 10, Pp 101181-(2021)
Translational Oncology
Translational Oncology
Highlights • The COX-2 encoding gene PTGS2 is up-regulated upon ABCB1 overexpression in mammary epithelial cells. • The 5-LOX, COX-1/2 inhibitor tepoxalin plus chemotherapy improves treatment efficacy in ABCB1-expressing cells. • Tepoxalin redu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::132c1de0e8b7f04032d3ec67bfa8ade9
http://www.sciencedirect.com/science/article/pii/S193652332100173X
http://www.sciencedirect.com/science/article/pii/S193652332100173X
Akademický článek
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Autor:
Eric Stefan, Evan Lemire, Sam Bender, Jesse S. Boehm, Li Wang, David Peck, John G. Doench, Christopher C. Mader, Matthew Meyerson, Ayshwarya Subramanian, Steven M. Corsello, Yii-Der Ida Chen, Jordan Rossen, Rohith T. Nagari, Joshua Bittker, James M. McFarland, Rajiv Narayan, Mustafa Kocak, Uri Ben-David, Matthew G. Rees, Vickie M. Wang, Nancy Dumont, Xiaoyun Wu, Anna Tang, Jordan Bryan, Ranad Humeidi, Ryan Spangler, Todd R. Golub, Francisca Vazquez, Nicholas J. Lyons, Philip Montgomery, Aviad Tsherniak, Bang Wong, Patrick O'Hearn, Heidi Greulich, Jennifer Roth
Anti-cancer uses of non-oncology drugs have been found on occasion, but such discoveries have been serendipitous and rare. We sought to create a public resource containing the growth inhibitory activity of 4,518 drugs tested across 578 human cancer c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32b7b1b0449043021c7614213c798146
Autor:
Jennifer J. Bushey, Corri B. Levine, Carolyn S. Sevier, D. Cavatorta, John P. Loftus, Joseph J. Wakshlag
Publikováno v:
Veterinary and Comparative Oncology. 14:e17-e30
The 5-lipoxygenase (5-LOX) inhibitor tepoxalin has been shown to slow canine osteosarcoma (OSA) tumour xenografts growth, yet the mechanisms are poorly elucidated. Further examination of tepoxalin in canine OSA cell lines shows that tepoxalin treated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0ab0fa6d5f475b46eb801dcc832b4d8
https://doi.org/10.1111/vco.12094
https://doi.org/10.1111/vco.12094
Publikováno v:
American Journal of Veterinary Research. 74:939-944
Objective—To determine whether tepoxalin alters kidney function in dogs with chronic kidney disease (CKD). Animals—16 dogs with CKD (International Renal Interest Society stage 2 or 3) and osteoarthritis. Procedures—Kidney function was assessed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968db04f029cf7ed555a9d82e302b958
https://doi.org/10.2460/ajvr.74.6.939
https://doi.org/10.2460/ajvr.74.6.939
Autor:
Evelyne Meyer, Siska Croubels, Eva Neirinckx, P. De Backer, S. De Baere, Rudi Beyaert, S. De Boever
Publikováno v:
Journal of Veterinary Pharmacology and Therapeutics. 33:564-572
The pharmacodynamic properties of tepoxalin, Na-salicylate and ketoprofen were determined in an intravenous lipopolysaccharide (LPS) inflammation model in broiler chickens. The drugs were administered orally at a dose of 30, 50 and 3 mg/kg, respectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47af1fa9aad4517968a8f89a14502b25
https://doi.org/10.1111/j.1365-2885.2010.01184.x
https://doi.org/10.1111/j.1365-2885.2010.01184.x
Publikováno v:
Journal of Veterinary Pharmacology and Therapeutics. 32:97-100
Tepoxalin, [5(4-chlorophenyl)-N-hydroxy-(4-methoxyphenyl)N-methyl-1H-pyrazole-3-propanamide], is an orally active dual cyclooxygenase ⁄ lipoxygenase inhibitor, with a favourable gastrointestinal profile with respect to gastric mucosal injury (Walla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cce7ab9a53ba1288aa4775d86033520
https://doi.org/10.1111/j.1365-2885.2008.01000.x
https://doi.org/10.1111/j.1365-2885.2008.01000.x
Autor:
Lisa R. Reynolds, Bryan T. Torres, J. Punke, Laura A. Goodman, Steven C. Budsberg, Abbie L. Speas, A. Ellis
Publikováno v:
Journal of Veterinary Internal Medicine. 23:56-62
Background: Little is known about the effect of dual cyclooxygenase (COX) and lipoxygenase inhibition on canine gastric mucosal healing. Objective: This study compares the effects of putative dual COX and 5-lipoxygenase inhibition with that of COX-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b33e0fedf6320a1ca466d1eebad220
https://doi.org/10.1111/j.1939-1676.2008.0226.x
https://doi.org/10.1111/j.1939-1676.2008.0226.x
Publikováno v:
American Journal of Veterinary Research. 69:1203-1209
Objective—To evaluate the in vivo effects of firocoxib, meloxicam, and tepoxalin on prostaglandin (PG) and leukotriene production in duodenal mucosa and other target tissues in dogs with chronic osteoarthritis (OA). Animals—8 dogs with chronic, u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf2e5d25858943576ca91195595630a
https://doi.org/10.2460/ajvr.69.9.1203
https://doi.org/10.2460/ajvr.69.9.1203