A phage-encoded RNA-binding protein inhibits the antiviral activity of a toxin-antitoxin system.

Autor: Guegler CK; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Teodoro GIC; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Srikant S; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Chetlapalli K; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Doering CR; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Ghose DA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Laub MT; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2024 Feb 09; Vol. 52 (3), pp. 1298-1312.

Toxic anti-phage defense proteins inhibited by intragenic antitoxin proteins.

Autor: Zhong A; Division of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA., Jiang X; Intramural Research Program, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA., Hickman AB; Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA., Klier K; Division of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA., Teodoro GIC; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Dyda F; Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA., Laub MT; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA., Storz G; Division of Molecular and Cellular Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 May 02. Date of Electronic Publication: 2023 May 02.

The DarTG toxin-antitoxin system provides phage defence by ADP-ribosylating viral DNA.

Autor: LeRoux M; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Srikant S; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Teodoro GIC; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Zhang T; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Littlehale ML; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Doron S; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel., Badiee M; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA., Leung AKL; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.; Department of Molecular Biology and Genetics, Department of Genetic Medicine, Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA., Sorek R; Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel., Laub MT; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. laub@mit.edu.; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA. laub@mit.edu.

Publikováno v: Nature microbiology [Nat Microbiol] 2022 Jul; Vol. 7 (7), pp. 1028-1040. Date of Electronic Publication: 2022 Jun 20.