Výsledky vyhledávání - "Teodora Randelovic"

Akademický článek

Tetralol derivative NNC-55-0396 targets hypoxic cells in the glioblastoma microenvironment: an organ-on-chip approach

Autor: Clara Bayona, Lía Alza, Teodora Ranđelović, Marta C. Sallán, Anna Visa, Carles Cantí, Ignacio Ochoa, Sara Oliván, Judit Herreros

Publikováno v: Cell Death and Disease, Vol 15, Iss 2, Pp 1-8 (2024)

Abstract Glioblastoma (GBM) is a highly malignant brain tumour characterised by limited treatment options and poor prognosis. The tumour microenvironment, particularly the central hypoxic region of the tumour, is known to play a pivotal role in GBM p

Externí odkaz: https://doaj.org/article/e4a3f5b50b37495b857d31489a765008

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Akademický článek

Analysis of the Parametric Correlation in Mathematical Modeling of In Vitro Glioblastoma Evolution Using Copulas

Autor: Jacobo Ayensa-Jiménez, Marina Pérez-Aliacar, Teodora Randelovic, José Antonio Sanz-Herrera, Mohamed H. Doweidar, Manuel Doblaré

Publikováno v: Mathematics, Vol 9, Iss 1, p 27 (2020)

Modeling and simulation are essential tools for better understanding complex biological processes, such as cancer evolution. However, the resulting mathematical models are often highly non-linear and include many parameters, which, in many cases, are

Externí odkaz: https://doaj.org/article/7e6c7c2855954fd480d465d145fde970

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Surface modifications of COP-based microfluidic devices for improved immobilisation of hydrogel proteins: long-term 3D culture with contractile cell types and ischaemia model

Autor: Sandra González-Lana, Teodora Randelovic, Jesús Ciriza, María López-Valdeolivas, Rosa Monge, Carlos Sánchez-Somolinos, Ignacio Ochoa

The tissue microenvironment plays a crucial role in tissue homeostasis and disease progression. However, the in vitro simulation has been limited by the lack of adequate biomimetic models in the last decades. Thanks to the advent of microfluidic tech

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94aa741803a3c030993f09a216f43c94
http://zaguan.unizar.es/record/126225

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A mechanobiological model for tumor spheroid evolution with application to glioblastoma: A continuum multiphysics approach

Autor: Ana Carrasco-Mantis, Teodora Randelovic, Héctor Castro-Abril, Ignacio Ochoa, Manuel Doblaré, José A. Sanz-Herrera

Publikováno v: Computers in Biology and Medicine. 159:106897

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) Background: Spheroids are in vitro quasi-spherical structures of cell aggregates, eventually cultured within a hydrogel matrix, that are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bf43e5295980c24619c8ef205a6d91b
https://doi.org/10.1016/j.compbiomed.2023.106897

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Surface Modifications of COP-Based Microfluidic Devices for Improved Immobilization of Hydrogel Proteins: Long Term 3D Culture with Contractile Cell Types and Ischemia Model

Autor: Sandra González Lana, Teodora Randelovic, Jesús Ciriza, María López-Valdeolivas, Rosa Monge, Carlos Sánchez-Somolinos, Ignacio Ochoa

Publikováno v: Jornada de Jóvenes Investigadores del I3A. 10

Hydrogel confinement is critical in microfluidics to generate gradients, as cell remodelling process boundaries the development of biological models such as ischemia or fibrosis. Here, we test the immobilization efficiency of collagen hydrogels cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a646cb8e0bdea98cc81f5eac10cf569
https://doi.org/10.26754/jjii3a.20227230

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A mechanobiological model for tumor spheroids evolution: application to glioblastoma

Autor: Ignacio Ochoa, Ana Carrasco-Mantis, Manuel Doblaré, J.A. Sanz-Herrera, Héctor Alfonso Castro-Abril, Teodora Randelovic

Spheroids are in vitro spherical structures of cell aggregates, eventually cultured within a hydrogel matrix, that are used, among other applications, as a technological platform to investigate tumor formation and evolution. Several interesting featu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71ccdbd7ba402e2d65577812a1bd902a
https://doi.org/10.1101/2021.10.08.463617

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SpheroidJ: An Open-Source Set of Tools for Spheroid Segmentation

Autor: Yolanda Méndez, Jónathan Heras, David Lacalle, Vico Pascual, César Domínguez, Teodora Randelovic, Gadea Mata, Ignacio Ochoa, Héctor Alfonso Castro-Abril, Eloy Mata

Publikováno v: Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname

Background and objectives Spheroids are the most widely used 3D models for studying the effects of different micro-environmental characteristics on tumour behaviour, and for testing different preclinical and clinical treatments. In order to speed up

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41640da0320dcb0f51c87b6e685f4c15
http://zaguan.unizar.es/record/108312

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Author Correction: Enabling cell recovery from 3D cell culture microfluidic devices for tumour microenvironment biomarker profiling

Autor: María Virumbrales-Muñoz, Sara Oliván, Teodora Randelovic, Desirée Pereboom, Jose M. Ayuso, Alodia Lacueva, Luis J. Fernández, Ignacio Ochoa, Megan K. Livingston, David J. Beebe, Manuel Doblaré

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020)
Scientific Reports

The tumour microenvironment (TME) has recently drawn much attention due to its profound impact on tumour development, drug resistance and patient outcome. There is an increasing interest in new therapies that target the TME. Nonetheless, most establi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::092c30ec08da446b0e49013acd44492b
https://doi.org/10.1038/s41598-020-57830-0

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Microcompartmentalized cell-free protein synthesis in hydrogel μ-channels

Autor: Fernando López-Gallego, Lucía Moreno de Redrojo, Teodora Randelovic, Natalia Comino, Ana I. Benítez-Mateos, Nicoll Zeballos

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

The rapid demand for protein-based molecules has stimulated much research on cell-free protein synthesis (CFPS); however, there are still many challenges in terms of cost-efficiency, process intensification, and sustainability. Herein, we describe th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5b1766bb71cfd096f7b9a71259ff639
http://hdl.handle.net/10261/233218

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Mathematical formulation and parametric analysis of in vitro cell models in microfluidic devices: application to different stages of glioblastoma evolution

Autor: Jacobo Ayensa-Jiménez, Mohamed Hamdy Doweidar, Teodora Randelovic, Luis J. Fernández, Sara Oliván, Ignacio Ochoa, J.A. Sanz-Herrera, Manuel Doblaré, Marina Pérez-Aliacar

Publikováno v: Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
Scientific Reports
Zaguán. Repositorio Digital de la Universidad de Zaragoza
Consejo Superior de Investigaciones Científicas (CSIC)

In silico models and computer simulation are invaluable tools to better understand complex biological processes such as cancer evolution. However, the complexity of the biological environment, with many cell mechanisms in response to changing physica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1b2ca4e5ad3b4d5e955b45faf38c2ae
http://zaguan.unizar.es/record/97381

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