Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Tenzin Lungjangwa"'
Autor:
Xin Huang, Kyoung-mi Park, Paul Gontarz, Bo Zhang, Joshua Pan, Zachary McKenzie, Laura A. Fischer, Chen Dong, Sabine Dietmann, Xiaoyun Xing, Pavel V. Shliaha, Jihong Yang, Dan Li, Junjun Ding, Tenzin Lungjangwa, Maya Mitalipova, Shafqat A. Khan, Sumeth Imsoonthornruksa, Nick Jensen, Ting Wang, Cigall Kadoch, Rudolf Jaenisch, Jianlong Wang, Thorold W. Theunissen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Although the interactors of pluripotency factors have been identified in mouse embryonic stem cells (ESCs), their interactors in human ESCs remain unexplored. Here the authors map OCT4 protein interactions in naïve and primed human ESCs to find spec
Externí odkaz:
https://doaj.org/article/475ca4c998cb484bb6963209f6ebdc13
Autor:
Shafqat A. Khan, Kyoung-mi Park, Laura A. Fischer, Chen Dong, Tenzin Lungjangwa, Marta Jimenez, Dominick Casalena, Brian Chew, Sabine Dietmann, Douglas S. Auld, Rudolf Jaenisch, Thorold W. Theunissen
Publikováno v:
Cell Reports, Vol 35, Iss 11, Pp 109233- (2021)
Summary: Naive human embryonic stem cells (hESCs) have been isolated that more closely resemble the pre-implantation epiblast compared to conventional “primed” hESCs, but the signaling principles underlying these discrete stem cell states remain
Externí odkaz:
https://doaj.org/article/0ab0294c046a4f59a6b32af4c1a272a8
Autor:
Attya Omer Javed, Yun Li, Julien Muffat, Kuan-Chung Su, Malkiel A. Cohen, Tenzin Lungjangwa, Patrick Aubourg, Iain M. Cheeseman, Rudolf Jaenisch
Publikováno v:
Cell Reports, Vol 25, Iss 2, Pp 368-382.e5 (2018)
Summary: Most genes mutated in microcephaly patients are expressed ubiquitously, and yet the brain is the only major organ compromised in most patients. Why the phenotype remains brain specific is poorly understood. In this study, we used in vitro di
Externí odkaz:
https://doaj.org/article/2f620656beed49f08740a12579eca9ce
Autor:
Xin Tang, Gary LeRoy, Alicia V. Zamudio, Alessandra Dall’Agnese, Richard A. Young, Emile Wogram, Jurian Schuijers, Nancy M. Hannett, Jonathan E. Henninger, Tenzin Lungjangwa, Tong Ihn Lee, Jesse M. Platt, Eliot L. Coffey, Ozgur Oksuz, X. Shawn Liu, Styliani Markoulaki, Charles H. Li, Lena K. Afeyan, Rudolf Jaenisch, Devon S. Svoboda
Publikováno v:
Nature
Methyl CpG binding protein 2 (MeCP2) is a key component of constitutive heterochromatin, which is crucial for chromosome maintenance and transcriptional silencing1–3. Mutations in the MECP2 gene cause the progressive neurodevelopmental disorder Ret
Autor:
Christina M. Tringides, Marjolaine Boulingre, Andrew Khalil, Tenzin Lungjangwa, Rudolf Jaenisch, David J. Mooney
Publikováno v:
Advanced Healthcare Materials. 12:2202221
Multielectrode arrays would benefit from intimate engagement with neural cells, but typical arrays do not present a physical environment that mimics that of neural tissues. It is hypothesized that a porous, conductive hydrogel scaffold with appropria
Autor:
Marine A. Krzisch, Hao Wu, Bingbing Yuan, Troy W. Whitfield, X. Shawn Liu, Dongdong Fu, Carrie M. Garrett-Engele, Andrew S. Khalil, Tenzin Lungjangwa, Jennifer Shih, Aaron N. Chang, Stephen Warren, Angela Cacace, Kristin R. Andrykovich, Rosalie G.J. Rietjens, Owen Wallace, Mriganka Sur, Bhav Jain, Rudolf Jaenisch
Publikováno v:
Biological psychiatry. 93(1)
Fragile X syndrome (FXS) is characterized by physical abnormalities, anxiety, intellectual disability, hyperactivity, autistic behaviors, and seizures. Abnormal neuronal development in FXS is poorly understood. Data on patients with FXS remain scarce
Autor:
Dominick Casalena, Sabine Dietmann, Kyoung-mi Park, Tenzin Lungjangwa, Marta Jimenez, Laura A. Fischer, Chen Dong, Brian Chew, Thorold W. Theunissen, Douglas S. Auld, Shafqat Ali Khan, Rudolf Jaenisch
Publikováno v:
Cell Reports, Vol 35, Iss 11, Pp 109233-(2021)
Cell reports
Cell reports
SUMMARY Naive human embryonic stem cells (hESCs) have been isolated that more closely resemble the pre-implantation epiblast compared to conventional “primed” hESCs, but the signaling principles underlying these discrete stem cell states remain i
Autor:
Nick O Jensen, Maya Mitalipova, Jihong Yang, Xin Huang, Zachary M. McKenzie, Pavel V. Shliaha, Tenzin Lungjangwa, Cigall Kadoch, Sumeth Imsoonthornruksa, Xiaoyun Xing, Thorold W. Theunissen, Dan Li, Ting Wang, Chen Dong, Rudolf Jaenisch, Kyoung-mi Park, Shafqat Ali Khan, Sabine Dietmann, Junjun Ding, Jianlong Wang, Paul Gontarz, Laura A. Fischer, Joshua Pan, Bo Zhang
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Understanding the molecular underpinnings of pluripotency is a prerequisite for optimal maintenance and application of embryonic stem cells (ESCs). While the protein-protein interactions of core pluripotency factors have been identified in mouse ESCs
Autor:
Kirsten Schneider, Martin Trapecar, Devon S. Svoboda, Douglas A. Lauffenburger, Samuel Mildrum, Meelim J. Lee, Rudolf Jaenisch, Linda G. Griffith, Austin Hendricks, Jason Velazquez, Julien Muffat, Pierre Sphabmixay, Stuart S. Levine, Emile Wogram, Attya Omer, David L. Trumper, Catherine Communal, Charles W. Wright, Tenzin Lungjangwa
Publikováno v:
Science Advances
Engineered model of the human gut-liver-brain axis can be used to study the link between the microbiome and Parkinson’s disease.
Slow progress in the fight against neurodegenerative diseases (NDs) motivates an urgent need for highly controlled
Slow progress in the fight against neurodegenerative diseases (NDs) motivates an urgent need for highly controlled
Autor:
Lee Gehrke, Tenzin Lungjangwa, Mehreen Khan, Maria C. Virgilio, Heather R. Keys, Yun Li, Irene Bosch, Attya Omer Javed, Julien Muffat, David M. Sabatini, Rudolf Jaenisch
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(19)
Zika virus (ZIKV) is a neurotropic and neurovirulent arbovirus that has severe detrimental impact on the developing human fetal brain. To date, little is known about the factors required for ZIKV infection of human neural cells. We identified ZIKV ho