Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Tenzin Gocha"'
Autor:
Joo-Leng Low, Weina Du, Tenzin Gocha, Gokce Oguz, Xiaoqian Zhang, Ming Wei Chen, Srdan Masirevic, Daniel Guo Rong Yim, Iain Bee Huat Tan, Adaikalavan Ramasamy, Hao Fan, Ramanuj DasGupta
Publikováno v:
iScience, Vol 24, Iss 6, Pp 102544- (2021)
Summary: Here we report a molecular docking-based approach to identify small molecules that can target the β-catenin (β-cat)-TCF4 protein-protein interaction (PPI), a key effector complex for nuclear Wnt signaling activity. Specifically, we develop
Externí odkaz:
https://doaj.org/article/e9f8357f869441d0bb1ca3addf61bffd
Autor:
Chung-Yi Nien, Hsiao-Lan Liang, Stephen Butcher, Yujia Sun, Shengbo Fu, Tenzin Gocha, Nikolai Kirov, J Robert Manak, Christine Rushlow
Publikováno v:
PLoS Genetics, Vol 7, Iss 10, p e1002339 (2011)
In past years, much attention has focused on the gene networks that regulate early developmental processes, but less attention has been paid to how multiple networks and processes are temporally coordinated. Recently the discovery of the transcriptio
Externí odkaz:
https://doaj.org/article/fca76eb5d9714f979ab3278f6f518297
Autor:
Xiaoqian Zhang, Ramanuj DasGupta, Daniel G. Yim, Weina Du, Tenzin Gocha, Oguz Gokce, Hao Fan, Adaikalavan Ramasamy, Joo-Leng Low
Publikováno v:
Cancer Research. 80:509-509
Canonical Wnt signaling is one of the crucial pathways involved in embryonic development and tissue homeostasis. However this pathway is often dysregulated in cancers and thus developing effective inhibitors of Wnt signaling is of great interest in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef9aa891281278f3e38fa28e686dea99
https://doi.org/10.1158/1538-7445.am2020-509
https://doi.org/10.1158/1538-7445.am2020-509
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Notch signaling has important functions in regulating cell growth and development, misregulation of which has been implicated in various cancers. Monoclonal antibodies (mAbs) targeting Notch protein activity have already moved into clinical trials. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f6e994e43ea2ad6fa75c22b62c3cf4
http://europepmc.org/articles/PMC5607287
http://europepmc.org/articles/PMC5607287
Autor:
Tenzin Gocha, Abil Saj, Engin Cukuroglu, Sujash S. Chatterjee, Xiaoqian Zhang, Bowen Zhu, Ramanuj DasGupta, Jonathan Göke
Publikováno v:
Stem cells (Dayton, Ohio). 35(8)
The 2i-media, composed of two small molecule inhibitors (PD0325901 and CHIR99021) against MEK and GSK3-kinases, respectively, is known to establish naïve ground state pluripotency in mouse embryonic stem cells (mESCs). These inhibitors block MEK-med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08ba912164e4da9b778917a8a60c31e8
https://pubmed.ncbi.nlm.nih.gov/28577307
https://pubmed.ncbi.nlm.nih.gov/28577307
Autor:
Ramanuj DasGupta, Tenzin Gocha
Publikováno v:
Wnt Signaling in Development and Disease: Molecular Mechanisms and Biological Functions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bd9bd5e9e0e785ee0a9d0a3cc3525c8
https://doi.org/10.1002/9781118444122.ch10
https://doi.org/10.1002/9781118444122.ch10
Publikováno v:
Scientific Reports
Signaling proteins often form dynamic protein-protein interaction (PPI) complexes to achieve multi-functionality. Methods to abrogate a subset of PPI interfaces without depleting the full-length protein will be valuable for structure-function relatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c0085cbdedc23c7a439998da290b17b
Autor:
Nikolai Kirov, Shengbo Fu, Tenzin Gocha, Yujia Sun, Hsiao Lan Liang, Christine Rushlow, J. Robert Manak, Stephen Butcher, Chung Yi Nien
Publikováno v:
PLoS Genetics, Vol 7, Iss 10, p e1002339 (2011)
PLoS Genetics
PLoS Genetics
In past years, much attention has focused on the gene networks that regulate early developmental processes, but less attention has been paid to how multiple networks and processes are temporally coordinated. Recently the discovery of the transcriptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a09f3e9412257d312bb15769101f55d2
http://europepmc.org/articles/PMC3197689?pdf=render
http://europepmc.org/articles/PMC3197689?pdf=render
Autor:
Tenzin Gocha, Matthew Murphy, Foster C. Gonsalves, Penelope Hayward, Steven S. Shen, Abil Saj, Xiaoqian Zhang, Ramanuj DasGupta, Aviv Madar, Betul Akgol Oksuz, Sujash S. Chatterjee, Alfonso Martinez Arias
Publikováno v:
The Journal of Cell Biology
Blocking β-catenin/TCF1–mediated transcriptional activation with a specific small molecule or by TCF1 knockdown delays the mouse embryonic stem cell differentiation program and enhances pluripotency.
The ability of mouse embryonic stem cells
The ability of mouse embryonic stem cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cbc7f834c295d888f470482302fdfa2
https://doi.org/10.1084/jem.21211oia90
https://doi.org/10.1084/jem.21211oia90