Zobrazeno 1 - 10
of 499
pro vyhledávání: '"Tenogenic differentiation"'
Publikováno v:
Regenerative Therapy, Vol 26, Iss , Pp 792-799 (2024)
Introduction: Tendon-derived stem cells (TDSCs) play a critical role in tendon repair. N5-methylcytosine (m5C) is a key regulator of cellular processes such as differentiation. This study aimed to investigate the impact of m5C on TDSC differentiation
Externí odkaz:
https://doaj.org/article/03c271543d964ceaa9735f6d42354212
Autor:
Michaela Melzer, Sabine Niebert, Manuela Heimann, Franziska Ullm, Tilo Pompe, Georgios Scheiner-Bobis, Janina Burk
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The transforming growth factor (TGF)-β3 is a well-known inducer for tenogenic differentiation, signaling via the Smad2/3 pathway. Furthermore, other factors like extracellular matrix or mechanical force can induce tenogenic differentiation
Externí odkaz:
https://doaj.org/article/ac99be45c51f48d79bbf7d3e71441f3a
Autor:
Valentina Russo, Giuseppe Prencipe, Annunziata Mauro, Mohammad El Khatib, Arlette A. Haidar-Montes, Nico Cambise, Maura Turriani, Johannes Stöckl, Peter Steinberger, Loreto Lancia, Matthias Schnabelrauch, Paolo Berardinelli, Barbara Barboni
Publikováno v:
Materials Today Bio, Vol 25, Iss , Pp 101001- (2024)
Tendon diseases pose a significant challenge in regenerative medicine due to the limited healing capacity of this tissue. Successful tendon regeneration requires a combination of angiogenesis, immune response, and tenogenesis processes. An effective
Externí odkaz:
https://doaj.org/article/a12a126b76684f3f938188d3c9886f39
Publikováno v:
Journal of Orthopaedic Translation, Vol 43, Iss , Pp 1-13 (2023)
Background: High post-surgical failure rates following tendon injury generate high medical costs and poor patient recovery. Cell-based tendon tissue engineering has the potential to produce fully functional replacement tissue and provide new strategi
Externí odkaz:
https://doaj.org/article/b41b874e5fbc4c00812d885974fcc41b
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 18, Iss 1, Pp 1-11 (2023)
Abstract Background Tendon-derived stem cells (TDSCs) are one of stem cells characterized by greater clonogenicity, tenogenesis, and proliferation capacity. Circ_0005736 has been shown to be decreased in Rotator cuff tendinopathy. Here, we investigat
Externí odkaz:
https://doaj.org/article/77ff8325922340d3805db4fe293226bc
Akademický článek
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Akademický článek
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Autor:
Renwang Sheng, Jia Liu, Wei Zhang, Yifan Luo, Zhixuan Chen, Jiayu Chi, Qingyun Mo, Mingyue Wang, Yuzhi Sun, Chuanquan Liu, Yanan Zhang, Yue Zhu, Baian Kuang, Chunguang Yan, Haoyang Liu, Ludvig J. Backman, Jialin Chen
Publikováno v:
Advanced Science, Vol 10, Iss 17, Pp n/a-n/a (2023)
Abstract Stiffness is an important physical property of biomaterials that determines stem cell fate. Guiding stem cell differentiation via stiffness modulation has been considered in tissue engineering. However, the mechanism by which material stiffn
Externí odkaz:
https://doaj.org/article/d85d3a08d5df483ca2f539d2bcd5c7d4
Publikováno v:
Cell Journal, Vol 24, Iss 7, Pp 370-379 (2022)
Objective: Tendon repair strategies usually are accompanied by pathological mineralization and scar tissue formation that increases the risk of re-injuries. This study aimed to establish an efficient tendon regeneration method simultaneously with a r
Externí odkaz:
https://doaj.org/article/000956c13d1b49aab6223c8f9cb4b325
Publikováno v:
Journal of Experimental Orthopaedics, Vol 10, Iss 1, Pp n/a-n/a (2023)
Abstract Purpose Mesenchymal stem cells (MSCs) react dynamically with the surrounding microenvironment to promote tissue‐specific differentiation and hence increase targeted regenerative capacity. Extracellular matrix (ECM) would be the first micro
Externí odkaz:
https://doaj.org/article/50a879563bd8497bbe69638d7d5fcbaa