Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Tengli, Liu"'
Autor:
Na Liu, Rui Li, Jinglin Cao, Xinyao Song, Wenmiao Ma, Tengli Liu, Le Wang, Jiaqi Zou, Boya Zhang, Zewen Liu, Rui Liang, Rongxiu Zheng, Shusen Wang
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract The FK506-binding protein 51 (FKBP51, encoded by FKBP5 gene) has emerged as a critical regulator of mammalian endocrine stress responses and as a potential pharmacological target for metabolic disorders, including type 2 diabetes (T2D). Howe
Externí odkaz:
https://doaj.org/article/ca4f172e6c334f14bfd76fa8a9c67b29
Autor:
Tengli Liu, Peng Sun, Jiaqi Zou, Le Wang, Guanqiao Wang, Na Liu, Yaojuan Liu, Xuejie Ding, Boya Zhang, Rui Liang, Shusen Wang, Zhongyang Shen
Publikováno v:
BMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-7 (2021)
Abstract Background NKX6.1 is a transcription factor for insulin, as well as a marker for β cell maturity. Abnormal NKX6.1 expression in β cells, such as translocation from the nucleus to cytoplasm or lost expression, has been shown as a marker for
Externí odkaz:
https://doaj.org/article/7be8b0530fb243a7a5bbdf8ea9035c60
Autor:
Rui Liang, Na Liu, Guanqiao Wang, Peng Sun, Yaojuan Liu, Jiaqi Zou, Le Wang, Xuejie Ding, Boya Zhang, Zhongyang Shen, Tengli Liu, Shusen Wang
Publikováno v:
European Journal of Inflammation, Vol 19 (2021)
β cell dedifferentiation is a key mechanism for β cell dysfunction in type 2 diabetes mellitus (T2DM). Although it has been indicated in previous studies that β cell dedifferentiation could be induced by inflammation, the cytohistologic analyses o
Externí odkaz:
https://doaj.org/article/b4f7b631809044f380ba9b790386298d
Autor:
Le Wang, Tengli Liu, Rui Liang, Guanqiao Wang, Yaojuan Liu, Jiaqi Zou, Na Liu, Boya Zhang, Yan Liu, Xuejie Ding, Xiangheng Cai, Zhiping Wang, Xiumin Xu, Camillo Ricordi, Shusen Wang, Zhongyang Shen
Publikováno v:
EBioMedicine, Vol 51, Iss , Pp - (2020)
Background: A physiological hallmark of patients with type 2 diabetes mellitus (T2DM) is β cell dysfunction. Despite adequate treatment, it is an irreversible process that follows disease progression. Therefore, the development of novel therapies th
Externí odkaz:
https://doaj.org/article/5857bda823ef4772ad650b7a655cf302
Autor:
Jing Yang, Jinyang Zhen, Wenli Feng, Zhenqian Fan, Li Ding, Xiaoyun Yang, Yumeng Huang, Hua Shu, Jing Xie, Xin Li, Jingting Qiao, Yuxin Fan, Jinhong Sun, Na Li, Tengli Liu, Shusen Wang, Xiaona Zhang, Peter Arvan, Ming Liu
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(45)
Recessive mutations in IER3IP1 (immediate early response 3 interacting protein 1) cause a syndrome of microcephaly, epilepsy, and permanent neonatal diabetes (MEDS). IER3IP1 encodes an endoplasmic reticulum (ER) membrane protein, which is crucial for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bab309a9ebb352f9c3f6a034224ec6b
https://pubmed.ncbi.nlm.nih.gov/36322741
https://pubmed.ncbi.nlm.nih.gov/36322741
Autor:
Yuanyuan Du, Zhen Liang, Shusen Wang, Dong Sun, Xiaofeng Wang, Soon Yi Liew, Shuaiyao Lu, Shuangshuang Wu, Yong Jiang, Yaqi Wang, Boya Zhang, Wenhai Yu, Zhi Lu, Yue Pu, Yun Zhang, Haiting Long, Shanshan Xiao, Rui Liang, Zhengyuan Zhang, Jingyang Guan, Jinlin Wang, Huixia Ren, Yanling Wei, Jiaxu Zhao, Shicheng Sun, Tengli Liu, Gaofan Meng, Le Wang, Jiabin Gu, Tao Wang, Yinan Liu, Cheng Li, Chao Tang, Zhongyang Shen, Xiaozhong Peng, Hongkui Deng
Publikováno v:
Nature Medicine. 28:272-282
Human pluripotent stem-cell-derived islets (hPSC-islets) are a promising cell resource for diabetes treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ccd18265552237415f573446f3a5be4
https://doi.org/10.1038/s41591-021-01645-7
https://doi.org/10.1038/s41591-021-01645-7
Autor:
Rui Liang, Jianyu Wang, Shusen Wang, Jing Yang, Ming Liu, Na Li, Jinyang Zhen, Yumeng Huang, Tengli Liu
Publikováno v:
European Journal of Endocrinology. 185:565-576
Objective Progressive beta-cell dysfunction is a hallmark of type 2 diabetes (T2D). Increasing evidence indicates that over-stimulating proinsulin synthesis causes proinsulin misfolding and impairs insulin maturation and storage in db/db mice. Howeve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0616614329f806f1d2e2e87ee1db0bc8
https://doi.org/10.1530/eje-21-0144
https://doi.org/10.1530/eje-21-0144
Autor:
JING YANG, JINYANG ZHEN, WENLI FENG, ZHENQIAN FAN, YUMENG HUANG, HUA SHU, XIN LI, JINGTING QIAO, YUXIN FAN, JINHONG SUN, NA LI, TENGLI LIU, SHUSEN WANG, XIAONA ZHANG, PETER ARVAN, MING LIU
Publikováno v:
Diabetes. 71
Recessive mutations in IER3IP1 (Immediate Early Response 3 Interacting Protein 1) cause a triad of microcephaly, epilepsy, and permanent neonatal diabetes syndrome (MEDS) . IER3IP1 encodes an endoplasmic reticulum (ER) membrane protein, which is cruc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d23b2e7ebed4e22aa75da7ef7fc87829
https://doi.org/10.2337/db22-200-or
https://doi.org/10.2337/db22-200-or
Autor:
Yongci Zhang, Wenhao Niu, Lida Sun, Lu Tan, Huili Zhao, Tengli Liu, Shuaini Yang, Gaoju Pang, Jiajia Zeng, Hong Bai, Sai Qiao, Yueyue Xu, Hong Zhang, Xiaoyu Zha, Ningbo Zheng
Publikováno v:
The Journal of Immunology. 206:1586-1596
The IL-21/IL-21R interaction plays an important role in a variety of immune diseases; however, the roles and mechanisms in intracellular bacterial infection are not fully understood. In this study, we explored the effect of IL-21/IL-21R on chlamydial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::818ccfe0e861e5f60e0907f8eb0a4a26
https://doi.org/10.4049/jimmunol.2001107
https://doi.org/10.4049/jimmunol.2001107
Autor:
Jiaqi Zou, Peng Sun, Le Wang, Tengli Liu, Shusen Wang, Guanqiao Wang, Xuejie Ding, Zhongyang Shen, Yaojuan Liu, Boya Zhang, Rui Liang, Na Liu
Publikováno v:
BMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-7 (2021)
BMC Endocrine Disorders
BMC Endocrine Disorders
Background NKX6.1 is a transcription factor for insulin, as well as a marker for β cell maturity. Abnormal NKX6.1 expression in β cells, such as translocation from the nucleus to cytoplasm or lost expression, has been shown as a marker for β cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033f04cdf2b1b75cf018f9fe5f36df16
https://doaj.org/article/7be8b0530fb243a7a5bbdf8ea9035c60
https://doaj.org/article/7be8b0530fb243a7a5bbdf8ea9035c60