Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Teng-Man Chen"'
Autor:
Jian Shen, Jiping Yang, Winfried Heyse, Harald Schweitzer, Norbert Nagel, Doris Andert, Chengyue Zhu, Vincent Morrison, Gregory A. Nemeth, Teng-Man Chen, Zhicheng Zhao, Timothy A. Ayers, Yong-Mi Choi
Publikováno v:
Journal of Pharmaceutical Analysis, Vol 4, Iss 3, Pp 197-204 (2014)
Otamixaban is a potent (Ki=0.5Â nM) fXa inhibitor currently in late-stage clinical development at Sanofi for the management of acute coronary syndrome. Being unproductive in obtaining a suitable crystal of Otamixaban, the required enantiomeric chara
Externí odkaz:
https://doaj.org/article/e216df50786d432c972e05ee222dd331
Autor:
Jiping Yang, Jian Shen, Winfried Heyse, Doris Andert, Harald Schweitzer, Chengyue Zhu, Gregory A. Nemeth, Yong-Mi Choi, Zhicheng Zhao, Timothy A. Ayers, Vincent Morrison, Teng-Man Chen, Norbert Nagel
Publikováno v:
Journal of Pharmaceutical Analysis
Journal of Pharmaceutical Analysis, Vol 4, Iss 3, Pp 197-204 (2014)
Journal of Pharmaceutical Analysis, Vol 4, Iss 3, Pp 197-204 (2014)
Otamixaban is a potent (Ki=0.5Â nM) fXa inhibitor currently in late-stage clinical development at Sanofi for the management of acute coronary syndrome. Being unproductive in obtaining a suitable crystal of Otamixaban, the required enantiomeric chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::286fd0572070c3d598a63939b6535cd2
Publikováno v:
Chirality. 17:S84-S92
The ability ammonium trifluoroacetate as an additive for elution of acids and bases from derivatized polysaccharide chiral stationary phases was first observed in the process of developing normal-phase chiral HPLC methods in our lead-generation progr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eee0136826257862d909c6cb6d096178
https://doi.org/10.1002/chir.20115
https://doi.org/10.1002/chir.20115
Autor:
Julie L. Geary, Melinda A. Correll, J. Chuck Poole, Xiao-Gao Liu, Larry D. Bratton, Fred E. Boyer, Thomas N. Thompson, Teng-Man Chen, Arun K. Mandagere, Bryan K. Jones, Kin-Kai Hwang, Mark E. Webster, Robert W. Knippenberg, Maynard George D, Stephen W. Horgan, Deborah E. Logan, Tieu-Binh Le, Kudlacz Elizabeth M, David L. Wenstrup, Burkholder Timothy P, Raymond S. Gross, David W. Freund
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2531-2536
We recently described the synthesis and characterization of MDL 105,212, a non peptide tachykinin antagonist with high affinity for NK1 and NK2 receptors.1 Here we report the synthesis and structure-activity relationships for a series of analogs of M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6a5ed5f48c9a57f6ec7d3becd618960
https://doi.org/10.1016/s0960-894x(97)10013-0
https://doi.org/10.1016/s0960-894x(97)10013-0
Autor:
Bruce M. Baron, Teng-Man Chen, Christopher J. Schmidt, K.D. Haegele, Kenneth E. Cornelius, G.M. Fadayel
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 14:143-150
A liquid chromatographic (LC) method with precolumn derivatization and fluorescence detection has been developed for the quantitation of (R)-4-oxo-5-phosphononorvaline (MDL 100,453), which is a selective antagonist of N-methyl-D-aspartate receptor, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69fecfb7120bfffab8ee8ccba454f57c
https://doi.org/10.1016/0731-7085(95)01604-x
https://doi.org/10.1016/0731-7085(95)01604-x
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aff80a40ed420f3a1190e553f6e6b82f
https://doi.org/10.1002/chin.199802209
https://doi.org/10.1002/chin.199802209
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 9:929-933
Thermospray liquid chromatography—mass spectrometry (TSP LC—MS) was used to determine human urinary metabolites of terfenadine after oral administration of terfenadine tablets. In addition to the two previously identified major metabolites, azacy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e87dc6e7a7660515efc2cb71c5f75019
https://doi.org/10.1016/0731-7085(91)80025-5
https://doi.org/10.1016/0731-7085(91)80025-5
Curtatoxins. Neurotoxic insecticidal polypeptides isolated from the funnel-web spider Hololena curta
Autor:
G. W. Gorder, Teng-Man Chen, Alan D. Cardin, George D. Manley, M. G. Palfreyman, Bradley L. Ackermann, A. Stapleton, John E. Coutant, Dale T. Blankenship
Publikováno v:
Journal of Biological Chemistry. 265:2054-2059
Three polypeptide neurotoxins (curtatoxins) were isolated from the venom of the spider Hololena curta by reverse-phase high performance liquid chromatography, gel permeation, and ion-exchange chromatography. The purified toxins induced an immediate p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d1ad70e1f285a691b493d937928dc08
https://doi.org/10.1016/s0021-9258(19)39939-9
https://doi.org/10.1016/s0021-9258(19)39939-9
Autor:
Teng-Man Chen, Harlan K Jones
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 809(1)
MDL 28170, Cbz-(L)-Val-(D,L)-Phe-H, which exists as a mixture of L,L- and L,D-diastereoisomers, is a calpain inhibitor currently investigated as a novel therapeutic agent for the treatment of ischemic stroke and head and spinal trauma. This report de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6c344d78a53952aeab74a7d4c4f59b5
https://pubmed.ncbi.nlm.nih.gov/15282090
https://pubmed.ncbi.nlm.nih.gov/15282090
Publikováno v:
Combinatorial chemistryhigh throughput screening. 5(7)
Aqueous solubility is a critical physicochemical property and must be addressed early during drug discovery research. Due to the difficulty in accurately predicting aqueous solubility in silico, high throughput experimental determination of aqueous s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b352bf989bf71d6686de6c5360c72a3d
https://pubmed.ncbi.nlm.nih.gov/12470271
https://pubmed.ncbi.nlm.nih.gov/12470271