Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Teng-Kuang Yeh"'
Autor:
Chi-Shuan Fan, Hui-Chen Hung, Chia-Chi Chen, Li-Li Chen, Yi-Yu Ke, Teng-Kuang Yeh, Chin-Ting Huang, Teng-Yuan Chang, Kuei-Jung Yen, Chung-Hsing Chen, Kee Voon Chua, John Tsu-An Hsu, Tze-Sing Huang
Publikováno v:
Cells, Vol 13, Iss 13, p 1146 (2024)
Extracellular HSP90α (eHSP90α) is a promoter of tumor development and malignant progression. Patients with malignancies, including pancreatic ductal adenocarcinoma (PDAC), have generally shown 5~10-fold increases in serum/plasma eHSP90α levels. In
Externí odkaz:
https://doaj.org/article/7f1e6fbce9c44310ab86b1c52d5b666f
Autor:
Chi-Hsiao Yeh, Zhao-Qing Shen, Tai-Wen Wang, Cheng-Heng Kao, Yuan-Chi Teng, Teng-Kuang Yeh, Chung-Kuang Lu, Ting-Fen Tsai
Publikováno v:
Journal of Biomedical Science, Vol 29, Iss 1, Pp 1-21 (2022)
Abstract Background The human CISD2 gene is located within a longevity region mapped on chromosome 4q. In mice, Cisd2 levels decrease during natural aging and genetic studies have shown that a high level of Cisd2 prolongs mouse lifespan and healthspa
Externí odkaz:
https://doaj.org/article/d11df834c11b41a3ac3d234147818e8f
Autor:
Kuan-Hsun Huang, Yu-Tzu Liu, Pei-Yun Pan, Chen-Fu Lo, Kuan-Liang Liu, Teng-Kuang Yeh, Li-Rung Huang, Lun K. Tsou
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 151, Iss , Pp 113084- (2022)
We report the design, synthesis and evaluation of a class of phosphatidylserine-targeting zinc (II) dipicolylamine drug conjugates and show that conjugate 16b elicits immune cell infiltration and remodels the “cold” hepatic tumor microenvironment
Externí odkaz:
https://doaj.org/article/ee985b428abf4431ae21d1f35e2399d9
Autor:
Yi-Yu Ke, Tzu-Ting Peng, Teng-Kuang Yeh, Wen-Zheng Huang, Shao-En Chang, Szu-Huei Wu, Hui-Chen Hung, Tsu-An Hsu, Shiow-Ju Lee, Jeng-Shin Song, Wen-Hsing Lin, Tung-Jung Chiang, Jiunn-Horng Lin, Huey-Kang Sytwu, Chiung-Tong Chen
Publikováno v:
Biomedical Journal, Vol 43, Iss 4, Pp 355-362 (2020)
Background: The ongoing COVID-19 pandemic has caused more than 193,825 deaths during the past few months. A quick-to-be-identified cure for the disease will be a therapeutic medicine that has prior use experiences in patients in order to resolve the
Externí odkaz:
https://doaj.org/article/e5864b93b800488594d8308add042b7b
Autor:
Cheng-Wei Yang, Tzu-Ting Peng, Hsing-Yu Hsu, Yue-Zhi Lee, Szu-Huei Wu, Wen-Hsing Lin, Yi-Yu Ke, Tsu-An Hsu, Teng-Kuang Yeh, Wen-Zheng Huang, Jiunn-Horng Lin, Huey-Kang Sytwu, Chiung-Tong Chen, Shiow-Ju Lee
Publikováno v:
Biomedical Journal, Vol 43, Iss 4, Pp 368-374 (2020)
Background: New therapeutic options to address the ongoing coronavirus disease 2019 (COVID-19) pandemic are urgently needed. One possible strategy is the repurposing of existing drugs approved for other indications as antiviral agents for severe acut
Externí odkaz:
https://doaj.org/article/4be953e501304c2898e31ca6eb2497df
Autor:
Ching-Hua Tsai, Tai-Yu Chiu, Chiung-Tong Chen, Chia-Yu Hsu, Ya-Ru Tsai, Teng-Kuang Yeh, Kuan-Hsun Huang, Lun Kelvin Tsou
Publikováno v:
Frontiers in Chemistry, Vol 9 (2022)
An efficient Ugi multicomponent reaction with strain promoted azide-alkyne cycloaddition protocol has been utilized in concert or independently to prepare a small family of bioactive zinc(II) dipicolylamine (ZnDPA)-based SN-38 conjugates. With sequen
Externí odkaz:
https://doaj.org/article/2ccdd9e8534648cd83355ceef42b1ebd
Synthesis and Evaluation of Small Molecule Drug Conjugates Harnessing Thioester-Linked Maytansinoids
Autor:
Chen-Fu Lo, Tai-Yu Chiu, Yu-Tzu Liu, Li-Rung Huang, Teng-Kuang Yeh, Kuan-Hsun Huang, Kuan-Liang Liu, Chia-Yu Hsu, Ming-Yu Fang, Yu-Chen Huang, Tsu-An Hsu, Chiung-Tong Chen, Lun Kelvin Tsou
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1316 (2022)
Ligand-targeting drug conjugates are a class of clinically validated biopharmaceutical drugs constructed by conjugating cytotoxic drugs with specific disease antigen targeting ligands through appropriate linkers. The integrated linker-drug motif embe
Externí odkaz:
https://doaj.org/article/b45299c01a614df1a2a60ca89927679d
Autor:
Yun-Yu Chen, Chen-Fu Lo, Tai-Yu Chiu, Chia-Yu Hsu, Teng-Kuang Yeh, Ching-Ping Chen, Chen-Lung Huang, Chung-Yu Huang, Min-Hsien Wang, Yu-Chen Huang, Hsuan-Hui Ho, Yu-Sheng Chao, Joe C. Shih, Lun K. Tsou, Chiung-Tong Chen
Publikováno v:
Translational Oncology, Vol 14, Iss 1, Pp 100897- (2021)
Zinc(II)-dipicolylamine (Zn-DPA) has been shown to specifically identify and bind to phosphatidylserine (PS), which exists in bulk in the tumor microenvironment. BPRDP056, a Zn-DPA-SN38 conjugate was designed to provide PS-targeted drug delivery of a
Externí odkaz:
https://doaj.org/article/2b76954bdb9f4067b806fc35103e16df
Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer
Autor:
Safiulla Basha Syed, Hemant Arya, I-Hsuan Fu, Teng-Kuang Yeh, Latha Periyasamy, Hsing-Pang Hsieh, Mohane Selvaraj Coumar
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-18 (2017)
Abstract P-glycoprotein (P-gp) is a drug transporter that effluxes chemotherapeutic drugs and is implicated in the development of resistance of cancer cells to chemotherapeutic drugs. To date, no drug has been approved to inhibit P-gp and restore che
Externí odkaz:
https://doaj.org/article/8f1abc9fc04a4f1dbd447a375a78af9c
Autor:
Wen-Hsing Lin, Teng-Kuang Yeh, Weir-Torn Jiaang, Kuei-Jung Yen, Chun-Hwa Chen, Chin-Ting Huang, Shih-Chieh Yen, Shu-Yi Hsieh, Ling-Hui Chou, Ching-Ping Chen, Chun-Hsien Chiu, Li-Chun Kao, Yu-Sheng Chao, Chiung-Tong Chen, John T-A Hsu
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e83160 (2014)
Overexpression or/and activating mutation of FLT3 kinase play a major driving role in the pathogenesis of acute myeloid leukemia (AML). Hence, pharmacologic inhibitors of FLT3 are of therapeutic potential for AML treatment. In this study, BPR1J-340 w
Externí odkaz:
https://doaj.org/article/e5078208d61149adbf9f92f8697b3132