Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Tendy Chiang"'
Publikováno v:
European Respiratory Review, Vol 33, Iss 173 (2024)
Pulmonary mucociliary clearance (MCC) is an important defence mechanism of the respiratory system and clears pathogens and foreign particles from the airways. Understanding the effect of disease states, drugs, toxins and airway manipulations on MCC c
Externí odkaz:
https://doaj.org/article/6c714dd18c4845e0a755e8c11dff084b
Autor:
Audrey F. Duff, Joseph A. Jurcisek, Nikola Kurbatfinski, Tendy Chiang, Steven D. Goodman, Lauren O. Bakaletz, Michael T. Bailey
Publikováno v:
npj Biofilms and Microbiomes, Vol 10, Iss 1, Pp 1-17 (2024)
Abstract Otitis media (OM) is one of the most globally pervasive pediatric conditions. Translocation of nasopharynx-resident opportunistic pathogens like nontypeable Haemophilus influenzae (NTHi) assimilates into polymicrobial middle ear biofilms, wh
Externí odkaz:
https://doaj.org/article/7dc1ce1f9a604679a78738b2ac910e22
Autor:
Lisa Zhang, Natalie Kelly, Kimberly M Shontz, Cynthia L. Hill, Jacob T. Stack, Jazmin Calyeca, Laura Matrka, Audrey Miller, Susan D Reynolds, Tendy Chiang
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-11 (2024)
Abstract Backgorund Tissue-engineered tracheal grafts (TETG) can be recellularized by the host or pre-seeded with host-derived cells. However, the impact of airway disease on the recellularization process is unknown. Methods In this study, we determi
Externí odkaz:
https://doaj.org/article/c8663365f8a34af7bda24cdd051f1a1b
Autor:
Woo Yul Byun, Lumei Liu, Amanda Palutsis, Zheng Hong Tan, Rachel Herster, Kyle VanKoevering, Amy Manning, Tendy Chiang
Publikováno v:
Laryngoscope Investigative Otolaryngology, Vol 9, Iss 2, Pp n/a-n/a (2024)
Abstract Objective Bioengineered tracheal grafts are a potential solution for the repair of long‐segment tracheal defects. A recent advancement is partially decellularized tracheal grafts (PDTGs) which enable regeneration of host epithelium and ret
Externí odkaz:
https://doaj.org/article/e051e96468f04a1286af47ff54768f89
Autor:
Zheng Hong Tan, Sayali Dharmadhikari, Lumei Liu, Jane Yu, Kimberly M. Shontz, Jacob T. Stack, Christopher K. Breuer, Susan D. Reynolds, Tendy Chiang
Publikováno v:
npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-11 (2023)
Abstract Extensive tracheal injury or disease can be life-threatening but there is currently no standard of care. Regenerative medicine offers a potential solution to long-segment tracheal defects through the creation of scaffolds that support the ge
Externí odkaz:
https://doaj.org/article/c0db940d1af44a219fa5135946c3d2e3
Autor:
Zheng Hong Tan, Lumei Liu, Sayali Dharmadhikari, Kimberly M. Shontz, Lily Kreber, Sarah Sperber, Jane Yu, Woo Yul Byun, Sarah C. Nyirjesy, Amy Manning, Susan D. Reynolds, Tendy Chiang
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 5, Pp n/a-n/a (2023)
Abstract There is currently no suitable autologous tissue to bridge large tracheal defects. As a result, no standard of care exists for long‐segment tracheal reconstruction. Tissue engineering has the potential to create a scaffold from allografts
Externí odkaz:
https://doaj.org/article/bcdddcce2bf248b9b183f8fcd96b38e4
Autor:
Natalie A. Kelly, Kimberly M. Shontz, Maxwell Bergman, Amy M. Manning, Susan D. Reynolds, Tendy Chiang
Publikováno v:
Laryngoscope Investigative Otolaryngology, Vol 7, Iss 6, Pp 2119-2125 (2022)
Abstract Objective While airway epithelial biorepositories have established roles in the study of bronchial progenitor stem (basal) cells, the utility of a bank of tracheal basal cells from pediatric patients, who have or are suspected of having an a
Externí odkaz:
https://doaj.org/article/5a57212022564004a284554bf0e5aa41
Autor:
Audrey N. Miller, Edward G. Shepherd, Amy Manning, Humra Shamim, Tendy Chiang, George El-Ferzli, Leif D. Nelin
Publikováno v:
Biomedicines, Vol 11, Iss 9, p 2572 (2023)
Infants with the most severe forms of bronchopulmonary dysplasia (BPD) may require long-term invasive positive pressure ventilation for survival, therefore necessitating tracheostomy. Although life-saving, tracheostomy has also been associated with h
Externí odkaz:
https://doaj.org/article/b762bf5926df4d82808521ebd485e8e1
Autor:
Moumita Ghosh, Cynthia L. Hill, Alfahdah Alsudayri, Scott W. Lallier, Don Hayes Jr., Saranga Wijeratne, Zhang Hong Tan, Tendy Chiang, John E. Mahoney, Gianni Carraro, Barry R. Stripp, Susan D. Reynolds
Publikováno v:
Stem Cells Translational Medicine, Vol 10, Iss 12, Pp 1696-1713 (2021)
Abstract Chronic lung disease has been attributed to stem cell aging and/or exhaustion. We investigated these mechanisms using mouse and human tracheobronchial tissue‐specific stem cells (TSC). In mouse, chromatin labeling and flow cytometry demons
Externí odkaz:
https://doaj.org/article/9d6a17e6e3c24ef9bf31f1af6b2661cd
Autor:
Susan D. Reynolds, Cynthia L. Hill, Alfahdah Alsudayri, Scott W. Lallier, Saranga Wijeratne, Zheng Hong Tan, Tendy Chiang, Estelle Cormet-Boyaka
Publikováno v:
JCI Insight, Vol 7, Iss 15 (2022)
Mucosecretory lung disease compromises airway epithelial function and is characterized by goblet cell hyperplasia and ciliated cell hypoplasia. Goblet and ciliated cell types are derived from tracheobronchial stem/progenitor cells via a Notch-depende
Externí odkaz:
https://doaj.org/article/6f3901496ceb49e7a15478a5f706a8b8