Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Tenagne Ayele"'
Autor:
Suresh Babubhai Chahwala, Tenagne Ayele, Chaman Chander, Stuart Buxton, Toby Jonathan Blench, Andrew Burd, Alexandra Watts, Richard Holland, Lihua Zhao, Michael Blackney, Sandrine A. M. Merette, Richard Beck, Shouming Wang, Maja Malic, Shaheda Shaikh
Publikováno v:
Journal of Medicinal Chemistry. 53:1465-1472
FIXa is a serine protease enzyme involved in the intrinsic pathway of the coagulation cascade. The upstream intervention of the coagulation cascade in selectively inhibiting FIXa would leave hemostasis intact via the extrinsic pathway, leading to an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f75946cb30138054257618191a17cc9
https://doi.org/10.1021/jm901475e
https://doi.org/10.1021/jm901475e
Autor:
Suresh Babubhai Chahwala, Elizabeth Murray, Chaman Chander, Michael Blackney, Stuart Buxton, Toby Jonathan Blench, Andrew Burd, Christine Baumgartner, Chiming Cheung, Amanda Giddings, Tenagne Ayele, Frederic Marlin, Shaheda Shaikh, Mohammed Sajad, Claudio Dagostin, Maja Malic, Hans-Peter Holthoff, John Barry, Richard Beck, Shouming Wang, Rina Joshi
Publikováno v:
Journal of medicinal chemistry. 53(4)
On the basis of our understanding on the binding interactions of the benzothiophene template within the FIXa active site by X-ray crystallography and molecular modeling studies, we developed our SAR strategy by targeting the 4-position of the templat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b68398f7bc5161feafed21edce2072
https://pubmed.ncbi.nlm.nih.gov/20121197
https://pubmed.ncbi.nlm.nih.gov/20121197