High interpatient variability of treosulfan exposure is associated with early toxicity in paediatric HSCT: a prospective multicentre study.

Autor: van der Stoep MYEC; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, the Netherlands., Bertaina A; Department of Paediatric Haematology and Oncology, Istituto di Ricovero e Cura a Carattere Scientifico Bambino Gesù Children's Hospital, Rome, University of Pavia, Pavia, Italy., Ten Brink MH; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, the Netherlands., Bredius RG; Department of Paediatrics, Leiden University Medical Centre, Leiden, the Netherlands., Smiers FJ; Department of Paediatrics, Leiden University Medical Centre, Leiden, the Netherlands., Wanders DCM; Department of Paediatrics, Leiden University Medical Centre, Leiden, the Netherlands., Moes DJAR; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, the Netherlands., Locatelli F; Department of Paediatric Haematology and Oncology, Istituto di Ricovero e Cura a Carattere Scientifico Bambino Gesù Children's Hospital, Rome, University of Pavia, Pavia, Italy., Guchelaar HJ; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, the Netherlands., Zwaveling J; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Centre, Leiden, the Netherlands., Lankester AC; Department of Paediatrics, Leiden University Medical Centre, Leiden, the Netherlands.

Publikováno v: British journal of haematology [Br J Haematol] 2017 Dec; Vol. 179 (5), pp. 772-780. Date of Electronic Publication: 2017 Oct 19.

Personalized busulfan and treosulfan conditioning for pediatric stem cell transplantation: the role of pharmacogenetics and pharmacokinetics.

Autor: ten Brink MH; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands., Zwaveling J; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands., Swen JJ; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands., Bredius RG; Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands., Lankester AC; Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands., Guchelaar HJ; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands. Electronic address: h.j.guchelaar@lumc.nl.

Publikováno v: Drug discovery today [Drug Discov Today] 2014 Oct; Vol. 19 (10), pp. 1572-86. Date of Electronic Publication: 2014 Apr 16.

Saliva as a noninvasive sampling matrix for therapeutic drug monitoring of intravenous busulfan in Chinese patients undergoing hematopoietic stem cell transplantation: A prospective population pharmacokinetic and simulation study.

Autor: Xu, Baohua^1,2 (AUTHOR), Yang, Ting³ (AUTHOR), Zhou, Jianxing^1,2 (AUTHOR), Zheng, You^1,2 (AUTHOR), Wang, Jingting⁴ (AUTHOR), Liu, Qingxia^1,2 (AUTHOR), Li, Dandan^1,2 (AUTHOR), Zhang, Yifan⁵ (AUTHOR), Liu, Maobai¹ (AUTHOR) liumb0591@fjmu.edu.cn, Wu, Xuemei¹ (AUTHOR) wuxuemei@fjmu.edu.cn

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology. Sep2023, Vol. 12 Issue 9, p1238-1249. 12p.

Exploratory analysis of 1936 SNPs in ADME genes for association with busulfan clearance in adult hematopoietic stem cell recipients.

Autor: Ten Brink MH; Departments of aClinical Pharmacy and Toxicology bMedical Statistics and Bioinformatics cHematology, Leiden University Medical Center, Leiden, The Netherlands., Swen JJ, Böhringer S, Wessels JA, van der Straaten T, Marijt EW, von dem Borne PA, Zwaveling J, Guchelaar HJ

Publikováno v: Pharmacogenetics and genomics [Pharmacogenet Genomics] 2013 Dec; Vol. 23 (12), pp. 675-83.

Pharmacogenetics in transplant patients: mind the mix.

Autor: Ten Brink MH; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands., van der Straaten T, Bouwsma H, Baak-Pablo R, Guchelaar HJ, Swen JJ

Publikováno v: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2013 Oct; Vol. 94 (4), pp. 443-4. Date of Electronic Publication: 2013 May 24.