Synthetic Amphipathic β-Sheet Temporin-Derived Peptide with Dual Antibacterial and Anti-Inflammatory Activities

Autor: Rosa Bellavita, Elisabetta Buommino, Bruno Casciaro, Francesco Merlino, Floriana Cappiello, Noemi Marigliano, Anella Saviano, Francesco Maione, Rosaria Santangelo, Maria Luisa Mangoni, Stefania Galdiero, Paolo Grieco, Annarita Falanga

Publikováno v: Antibiotics, Vol 11, Iss 10, p 1285 (2022)

Temporin family is one of the largest among antimicrobial peptides (AMPs), which act mainly by penetrating and disrupting the bacterial membranes. To further understand the relationship between the physical-chemical properties and their antimicrobial

Externí odkaz: https://doaj.org/article/cf5b7be86c234404a635bcda627218ea

Antifungal and Antibiofilm Activity of Cyclic Temporin L Peptide Analogues against Albicans and Non-Albicans Candida Species

Autor: Rosa Bellavita, Angela Maione, Francesco Merlino, Antonietta Siciliano, Principia Dardano, Luca De Stefano, Stefania Galdiero, Emilia Galdiero, Paolo Grieco, Annarita Falanga

Publikováno v: Pharmaceutics, Vol 14, Iss 2, p 454 (2022)

Temporins are one of the largest families of antimicrobial peptides with both anti-inflammatory and antimicrobial activity. Herein, for a panel of cyclic temporin L isoform analogues, the antifungal and antibiofilm activities were determined against

Externí odkaz: https://doaj.org/article/9aa6f9b3e1454bbb94732cf13c92448b

Novel Antimicrobial Peptide from Temporin L in The Treatment of Staphylococcus pseudintermedius and Malassezia pachydermatis in Polymicrobial Inter-Kingdom Infection

Autor: Rosa Bellavita, Adriana Vollaro, Maria Rosaria Catania, Francesco Merlino, Luisa De Martino, Francesca Paola Nocera, Marina DellaGreca, Francesca Lembo, Paolo Grieco, Elisabetta Buommino

Publikováno v: Antibiotics, Vol 9, Iss 9, p 530 (2020)

Interkingdom polymicrobial diseases are caused by different microorganisms that colonize the same niche, as in the case of yeast-bacteria coinfections. The latter are difficult to treat due the absence of any common therapeutic target for their elimi

Externí odkaz: https://doaj.org/article/a9e3cceca736448e8ee9ea466b5bab08

First-in-Class Cyclic Temporin L Analogue: Design, Synthesis, and Antimicrobial Assessment

Autor: Bruno Casciaro, Salvatore Di Maro, Floriana Cappiello, Stefania Galdiero, Alfonso Carotenuto, Maria Luisa Mangoni, Diego Brancaccio, Francesco Merlino, Tom N. Grossmann, Ettore Novellino, Paolo Grieco, Rosa Bellavita, Annarita Falanga, Elisabetta Buommino

Publikováno v: Journal of medicinal chemistry, 64(15), 11675-11694. American Chemical Society
Journal of Medicinal Chemistry
Bellavita, R, Casciaro, B, Di Maro, S, Brancaccio, D, Carotenuto, A, Falanga, A, Cappiello, F, Buommino, E, Galdiero, S, Novellino, E, Grossmann, T N, Mangoni, M L, Merlino, F & Grieco, P 2021, ' First-in-Class Cyclic Temporin L Analogue : Design, Synthesis, and Antimicrobial Assessment ', Journal of medicinal chemistry, vol. 64, no. 15, pp. 11675-11694 . https://doi.org/10.1021/acs.jmedchem.1c01033

The pharmacodynamic and pharmacokinetic properties of bioactive peptides can be modulated by introducing conformational constraints such as intramolecular macrocyclizations, which can involve either the backbone and/or side chains. Herein, we aimed a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb465bd9439290faeeb31e62a32610d3
https://doi.org/10.1021/acs.jmedchem.1c01033

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.