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Opioid receptor signaling, analgesic and side effects induced by a computationally designed pH-dependent agonist

Autor: Spahn, Viola, DelVecchio, Giovanna, Rodriguez-Gaztelumendi, Antonio, Temp, Julia, Labuz, Dominika, Kloner, Michael, Reidelbach, Marco, Machelska, Halina, Weber, Marcus, Stein, Christoph

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)

Novel pain killers without adverse effects are urgently needed. Opioids induce central and intestinal side effects such as respiratory depression, sedation, addiction, and constipation. We have recently shown that a newly designed agonist with a redu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b64452bbed3a92362b640235b4ba6a9c
https://doi.org/10.17169/refubium-2175

Author Correction: pKa of opioid ligands as a discriminating factor for side effects.

Autor: Del Vecchio, Giovanna, Labuz, Dominika, Temp, Julia, Seitz, Viola, Kloner, Michael, Negrete, Roger, Rodriguez-Gaztelumendi, Antonio, Weber, Marcus, Machelska, Halina, Stein, Christoph

Publikováno v: Scientific Reports; 3/4/2020, Vol. 10 Issue 1, p1-2, 2p

Opioid receptor signaling, analgesic and side effects induced by a computationally designed pH-dependent agonist.

Autor: Spahn V; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Anesthesiology and Intensive Care Medicine, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany., Del Vecchio G; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Anesthesiology and Intensive Care Medicine, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany., Rodriguez-Gaztelumendi A; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Anesthesiology and Intensive Care Medicine, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany.; Department of Drug Discovery and In Vitro Pharmacology, Laboratorios Dr. Esteve, Parc Científic de Barcelona, Barcelona, Spain., Temp J; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Anesthesiology and Intensive Care Medicine, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany., Labuz D; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Anesthesiology and Intensive Care Medicine, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany., Kloner M; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Anesthesiology and Intensive Care Medicine, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany., Reidelbach M; Freie Universität Berlin, Institute of Theoretical Physics, Arnimallee 14, 14195, Berlin, Germany., Machelska H; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Anesthesiology and Intensive Care Medicine, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany., Weber M; Zuse Institute Berlin, Computational Molecular Design, Takustraße 7, 14195, Berlin, Germany., Stein C; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Anesthesiology and Intensive Care Medicine, Campus Benjamin Franklin, Hindenburgdamm 30, 12203, Berlin, Germany. Christoph.stein@charite.de.

Publikováno v: Scientific reports [Sci Rep] 2018 Jun 12; Vol. 8 (1), pp. 8965. Date of Electronic Publication: 2018 Jun 12.