Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Temocaprilat"'
Autor:
Takaaki Nozawa, Teruko Imai
Publikováno v:
Drug Metabolism and Disposition. 39:1263-1269
Intestinal absorption of temocapril, a prodrug of temocaprilat, was evaluated in an in situ rat jejunal perfusion model under various conditions of luminal pH and in the presence and absence of carboxylesterase-mediated hydrolysis. Temocapril was mor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea704a184e0a631eea0f7fab441cc4c
https://doi.org/10.1124/dmd.110.037937
https://doi.org/10.1124/dmd.110.037937
Publikováno v:
Chemistry & Biodiversity. 6:2092-2100
Temocapril is a prodrug whose hydrolysis by carboxylesterase 1 (CES1) yields the active ACE inhibitor temocaprilat. This molecular-dynamics (MD) study uses a resolved structure of the human CES1 (hCES1) to investigate some mechanistic details of temo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7e5cc413fd911d0aad76d7e6552782
https://doi.org/10.1002/cbdv.200900174
https://doi.org/10.1002/cbdv.200900174
Autor:
Yoshihiro Yanagitani, Norio Komai, Norihisa Ito, Hiromi Rakugi, Yuji Tatara, Koichi Yamamoto, Toshio Ogihara, Norihiro Hayashi, Mitsuru Ohishi, Atsushi Shiota
Publikováno v:
American Journal of Hypertension. 20:792-799
Background Many experiments using young hypertensive animal models support the evidence that angiotensin-converting enzyme inhibitor or angiotensin receptor type 1 blocker attenuates the progression of cardiac hypertrophy. However, it is still unclea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45367905624205a973d245b8fd511ecb
https://doi.org/10.1016/j.amjhyper.2007.02.004
https://doi.org/10.1016/j.amjhyper.2007.02.004
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 316:176-181
This study was undertaken to evaluate a dosing time-dependent effect of temocapril, an angiotensin-converting enzyme (ACE) inhibitor, on the mortality of stroke-prone spontaneously hypertensive rats (SHRSP). Temocapril (1 mg/kg/day) prolonged the sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a456181f2d680dadc87e4608bb433fb1
https://doi.org/10.1124/jpet.105.092080
https://doi.org/10.1124/jpet.105.092080
Autor:
Dirk K. F. Meijer, Hans Lennernäs
Publikováno v:
European Journal of Pharmaceutical Sciences, 26(1), 130-143
EUFEPS conference on drug transporters at Copenhagen : integrative approaches in ADME research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::265311188730cd278adcb26dff73fbbf
https://doi.org/10.1016/j.ejps.2005.07.001
https://doi.org/10.1016/j.ejps.2005.07.001
Publikováno v:
Drug Metabolism and Disposition. 33:225-232
We investigated whether the species difference in the biliary excretion activity of some Mrp2 substrates was attributable to the intrinsic transport potential or the expression level of Mrp2, especially in rat and dog. Dog Mrp2 cDNA was isolated from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0147afa96c063fa7554e28b825126096
https://doi.org/10.1124/dmd.104.002196
https://doi.org/10.1124/dmd.104.002196
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 305:1087-1097
Our previous kinetic analyses have shown that rat organic anion transporter 1 (rOat1; Slc22a6) and rOat3 (Slc22a8) are responsible for the renal uptake of p-aminohippurate and pravastatin, respectively. In this study, their contribution to the renal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::122f3ce59fede493ef2d3152df3b7174
https://doi.org/10.1124/jpet.102.046847
https://doi.org/10.1124/jpet.102.046847
Autor:
Takeshi Tsujino, Takahiro Okumura, Mitsumasa Ohyanagi, Hiroshi Hosoai, Shinji Morimoto, Miho Masai, Yoshio Fujioka, Tadaaki Iwasaki, Tsuyoshi Sakoda
Publikováno v:
Hypertension Research. 26:315-323
Triglyceride-rich lipoproteins have been suggested to promote atherosclerosis. Plasminogen activator inhibitor type 1 (PAI-1) plays an important role in the events of cardiovascular pathophysiology. The renin-angiotensin system influences various vas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc4f66946baea30652e74101200a2564
https://doi.org/10.1291/hypres.26.315
https://doi.org/10.1291/hypres.26.315
Autor:
Toshiki Onishi, Kou Nishikawa, Hajime Takikawa, Atsuko Toda, Makoto Hojo, Hiroyuki Tanaka, Tatsuyuki Marumo, Hideki Tachizawa, Naoyo Sano, Naoko Hanawa
Publikováno v:
Hepatology Research. 24:136-140
Down-regulation of multidrug resistance protein 2 (Mrp2), a major canalicular organic anion transporter, has been reported in various cholestatic models and in patients with cholestasis. In the present study, biliary excretion of taurolithocholate-su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bfa34b78b295c47c2d0e33321789245
https://doi.org/10.1016/s1386-6346(02)00028-1
https://doi.org/10.1016/s1386-6346(02)00028-1
Autor:
Toshio Miyata, Kiyoshi Kurokawa, Reiko Inagi, Naoyoshi Ishikawa, Kohji Ichimori, Hiroshi Onogi, Yasuhiko Ueda, Charles van Ypersele de Strihou, Masaomi Nangaku
Publikováno v:
Journal of the American Society of Nephrology. 13:2478-2487
The implication of advanced glycation end products (AGE) in the pathogenesis of atherosclerosis and of diabetic and uremic complications has stimulated a search for AGE inhibitors. This study evaluates the AGE inhibitory potential of several well-tol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418b88f308df779fde069a1a69bcc8ab
https://doi.org/10.1097/01.asn.0000032418.67267.f2
https://doi.org/10.1097/01.asn.0000032418.67267.f2